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Chemical Compositions and Pharmacological Activities of Polygoni Multiflori Radix
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 13, Pages: 192-205(2019)
- 作者机构：
1.广东药科大学 中药学院，国家中医药管理局岭南药材生产与开发重点研究室，国家中药材产业技术体系广州综合试验站，广东省南药规范化种植与综合开发工程技术研究中心，广东 510006；
2.中国中医科学院 中药资源中心 道地药材国家重点实验室培育基地，北京 100700
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20191212
CLC： R282.6; R289; R22; R2-031Received：30 August 2018，
Published Online：05 March 2019，
Published：05 July 2019
- 稿件说明：
移动端阅览
Hao WANG, Jian YANG, Liang-yun ZHOU, et al. Chemical Compositions and Pharmacological Activities of Polygoni Multiflori Radix[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 192-205.
Hao WANG, Jian YANG, Liang-yun ZHOU, et al. Chemical Compositions and Pharmacological Activities of Polygoni Multiflori Radix[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(13): 192-205. DOI： 10.13422/j.cnki.syfjx.20191212.
摘要
何首乌为常见的补益类中药，在临床中具有广泛的应用。近年来有较多与何首乌相关的文献报道，通过对国内外相关文献进行整理和分析，概述何首乌的化学成分及其药理作用的研究进展。目前，已从何首乌中分离出二苯乙烯苷类、蒽醌类、黄酮类、磷脂类、苯丙素类以及其他化合物共133种，其中二苯乙烯苷二聚体以及二蒽酮苷是近期从何首乌中分离得到的两类新化合物。何首乌的药理活性研究主要有抗氧化、抗肿瘤、抗动脉粥样硬化以及神经保护等作用，在治疗神经退行性疾病、防治动脉粥样硬化、降血糖等方面具有潜力，其药效成分主要包括二苯乙烯苷类、蒽醌类以及黄酮类，其中二苯乙烯苷类中2，3，5，4′-四羟基二苯乙烯-2-
O
-葡萄糖苷即THSG显示出多种生物活性，但对何首乌中其他化合物药理活性的研究较少。因此，为保证何首乌的进一步开发利用，建议对其药效的物质基础进行更加深入、全面的研究。
Abstract
As a common tonic traditional Chinese medical herb
Polygoni Multiflori Radix has been extensively applied in clinic. In recent years
there have been many literatures related to Polygoni Multiflori Radix. By reviewing the literatures in domestic and foreign
the latest progress on chemical components and pharmacology of Polygoni Multiflori Radix have been summarized and analyzed. At present
more than 133 kinds of compounds have been isolated from Polygoni Multiflori Radix
such as stilbene glycosides
terpenoids
flavonoids
phospholipids and phenylpropanoids. Among them
stilbene dimer and dianthrone glycosides are two kind of new compounds recently isolated from it. The current researches about the pharmacological effect of Polygoni Multiflori Radix focus on anti-oxidative
anti-tumor
anti-atherosclerosis and neuro-protective effects
with potentials in treating neurodegenerative diseases
preventing and treating arterial and reducing blood sugar. Its medicinal ingredients mainly include stilbene glycosides
terpenoids and flavonoids
in which 2
3
5
4′-tetrahydroxysilbene 2-
O
-glucopyranoside shows a variety of biological activities. However
there are a few studies on the pharmacological activities of other compounds. Therefore
to ensure the further development and utilization of Polygoni Multiflori Radix
it is suggested to conduct a more in-depth and comprehensive research on the material basis of its efficacy.
关键词
Keywords
references
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