Clinical Efficacy of Wumeiwan Combined with Bazhentang in Treatment of Obese of Type 2 Diabetes Mellitus Patients with Qi and Yin Deficiencies, Phlegm and Stasis

Jie-hua HUANG; Xiao-min DENG; Cong CHEN; Geng-xu WU; Si-hua CHEN; Lan CHEN; Biao LUO; Dong SU; Ying TIAN

doi:10.13422/j.cnki.syfjx.20191225

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Clinical Efficacy of Wumeiwan Combined with Bazhentang in Treatment of Obese of Type 2 Diabetes Mellitus Patients with Qi and Yin Deficiencies, Phlegm and Stasis

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Wumeiwan Combined with Bazhentang in Treatment of Obese of Type 2 Diabetes Mellitus Patients with Qi and Yin Deficiencies, Phlegm and Stasis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 16, Pages: 56-60(2019)
- 作者机构：
  
  1.广西中医药大学，南宁　 530001；
  2.广西中医药大学　第一附属医院，南宁　 530023
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191225
  CLC： R22; R242; R2-031; R287
- Received：02 September 2018，
  
  Published Online：04 March 2019，
  
  Published：20 August 2019
- 稿件说明：
移动端阅览
Jie-hua HUANG, Xiao-min DENG, Cong CHEN, et al. Clinical Efficacy of Wumeiwan Combined with Bazhentang in Treatment of Obese of Type 2 Diabetes Mellitus Patients with Qi and Yin Deficiencies, Phlegm and Stasis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 56-60.
DOI：

Jie-hua HUANG, Xiao-min DENG, Cong CHEN, et al. Clinical Efficacy of Wumeiwan Combined with Bazhentang in Treatment of Obese of Type 2 Diabetes Mellitus Patients with Qi and Yin Deficiencies, Phlegm and Stasis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 56-60. DOI： 10.13422/j.cnki.syfjx.20191225.

摘要

目的：

观察乌梅丸合八珍汤加减治疗肥胖2型糖尿病气阴两虚夹痰瘀证的临床疗效。

方法：

将选取符合纳入标准的60例肥胖2型糖尿病气阴两虚夹痰瘀证患者按照随机数字法分为观察组、对照组，各30例。在糖尿病常规治疗基础上，观察组给予西医(盐酸二甲双胍)治疗，同时应用乌梅丸合八珍汤加减治疗。对照组采用常规西药(盐酸二甲双胍)治疗。疗程为8周，比较两组患者治疗前后空腹血糖(FPG)，餐后2 h血糖(2 hPG)，糖化血红蛋白(HbA1c)，总胆固醇(TC)，三酰甘油(TG)，体质量指数(BMI)水平、安全性指标(三大常规、肝肾功能)及临床症状的变化情况，并评价两组患者临床疗效。

结果：

观察组症状评分有效率为93.3%(28/30)，明显高于对照组的73.3%(22/30)(

0.05)。与本组治疗前比较，治疗后两组患者FPG，2 hPG，HbA1c水平均明显降低，且观察组治疗后FPG，2 hPG，HbA1c明显低于对照组(

0.05)；两组患者治疗后TC，TG，BMI水平及中医证候积分均明显降低(

0.05)，且观察组治疗后TC，TG，BMI水平及中医证候积分低于对照组(

0.05)。

结论：

乌梅丸合八珍汤对治疗肥胖2型糖尿病气阴两虚夹痰瘀证患者安全有效，且能降低患者血糖，血脂，BMI水平及减轻患者临床症状具有显著的疗效，值得推广。

Abstract

Objective:

To observe the clinical efficacy of Wumeiwan combined with Bazhentang in the treatment of obesity type 2 diabetes with Qi and Yin deficiencies

phlegm and stasis.

Method:

Totally 60 patients with type 2 diabetes mellitus were randomly divided into observation group and control group

with 30 cases in each group. Observation group was given Wumeiwan combined with modified Bazhentang in addition to Western medicine (metformin hydrochloride). The control group was treated with traditional Western medicine (metformin hydrochloride). The course of treatment is eight weeks. Fasting blood sugar (FPG)

2 hPG (2 hPG)

glycosylated hemoglobin (HbA1c)

total cholesterol (TC)

triglycerin (TG)

body mass index (BMI)

safety indicators (three major routine

liver and kidney functions) and clinical symptoms before and after treatment between two groups were compared. The clinical efficacy of two groups was evaluated.

Result:

The observation group had an effective rate of 93.3% (28/30)

which was significantly higher than 73.3% (22/30) of the control group

with statistically significant differences (

0.05). Compared with before treatment

the levels of FPG

2 hPG and HbA1c were significantly lower in two groups after treatment

and the treatment group was lower than control group (

0.05). The levels of TC

BMI and TCM syndromes were significantly reduced after treatment in two groups (

0.05)

and the levels of TC

BMI and TCM syndromes were significantly lower than those in control group. The differences were statistically significant (

0.05).

Conclusion:

Modified Wumeiwan combined with Bazhentang is safe and effective in treating patients with type 2 diabetes mellitus with Qi and Yin deficiencies

phlegm and stasis

and can reduce blood sugar

blood lipid

BMI level and relieve clinical symptoms of patients

and so worth promotion.

关键词

Keywords

references

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