Clinical Effect of Dahuang Zhechong Wan on Pelvic Pain Caused by Endometriosis with Qi Stagnation and Blood Stasis Syndrome

Qiong FAN; Yu-na WEI; Ling YIN; Xu CHEN

doi:10.13422/j.cnki.syfjx.20191231

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Clinical Effect of Dahuang Zhechong Wan on Pelvic Pain Caused by Endometriosis with Qi Stagnation and Blood Stasis Syndrome

Clinic | 更新时间：2021-02-09

- Clinical Effect of Dahuang Zhechong Wan on Pelvic Pain Caused by Endometriosis with Qi Stagnation and Blood Stasis Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 12, Pages: 121-126(2019)
- 作者机构：
  
  1.攀枝花市第二人民医院，四川　攀枝花　 617068；
  2.广西中医药大学，南宁　 530200；
  3.四川省妇幼保健院，成都　 610045
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191231
  CLC： R71; R289; R271; R271.1
- Received：07 December 2018，
  
  Published Online：22 January 2019，
  
  Published：20 June 2019
- 稿件说明：
移动端阅览
Qiong FAN, Yu-na WEI, Ling YIN, et al. Clinical Effect of Dahuang Zhechong Wan on Pelvic Pain Caused by Endometriosis with Qi Stagnation and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 121-126.
DOI：

Qiong FAN, Yu-na WEI, Ling YIN, et al. Clinical Effect of Dahuang Zhechong Wan on Pelvic Pain Caused by Endometriosis with Qi Stagnation and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 121-126. DOI： 10.13422/j.cnki.syfjx.20191231.

摘要

目的：

探讨大黄䗪虫丸治疗子宫内膜异位症盆腔疼痛(气滞血瘀证)的临床效果和其作用机制。

方法：

将126名患者经区组随机分为对照组64例和观察组62例。两组患者均口服地屈孕酮片，月经周期的第5～25天，1片/次，2次/d。对照组口服散结镇痛胶囊，4粒/次，3次/d，于月经来潮第1天开始服药，经期不停用；观察组口服大黄䗪虫丸，3 g/次，2次/d，经期不停用。两组患者疗程均为连续治疗3个月经周期。痛经情况采用疼痛视觉模拟评分(VAS)，分别于治疗前和治疗后1，2，3个月经周期各评价1次；进行治疗前后症状及体征评分、气滞血瘀证和子宫内膜异位症的专用生存质量评价量表(EHP-5)评分；进行治疗前后血液流变学检测；检测治疗前后基质金属蛋白酶-2(MMP-2)，MMP-9，肿瘤坏死因子-

(TNF-

)，白细胞介素-1(IL-1)，前列腺素E

(PGE

)，前列腺素F

(PGF

)和P 物质(SP)水平。

结果：

经秩和检验，观察组疾病疗效优于对照组(

＝2.198，

0.05)；观察组在治疗后1，2，3个月经周期VAS评分均低于对照组(

0.01)；治疗后观察组症状、体征评分、气滞血瘀证评分和EHP-5评分均低于对照组(

0.01)；观察组血液流变学指标[全血黏度(高切、低切)、血浆黏度、红细胞沉降率和血小板聚集率]的改善均优于对照组(

0.01)；观察组患者血清MMP-2，MMP-9，TNF-

，IL-1，PGF

和SP水平均低于对照组，PGE

高于对照组(

0.01)。

结论：

在孕激素治疗的基础上，采用大黄䗪虫丸治疗内膜异位症盆腔疼痛(气滞血瘀证)患者可进一步的减轻盆腔疼痛相关症状，提高了患者生活质量和临床疗效，并具有调节前列腺素、基质金属蛋白酶及促炎因子水平等作用。

Abstract

Objective:

To discuss the clinical effect of Dahuang Zhechong Wan on pelvic pain caused by endometriosis with Qi stagnation and blood stasis syndrome and study the mechanism of action.

Method:

One hundred and twenty-six patients were randomly divided into control group (64 cases) and observation group (62 cases) by random number table. Both groups’ patients got Duphaston from the 5

to 25

days of menstrual cycle

1 tablet/day

2 times/days. Patients in control group got Sanjie Zhentong Jiaonang at the first day of menstruation

4 grains/time

3 times/days. Patients in observation group got Dahuang Zhechong Wan

3 g/time

2 times/days. The treatment in two groups continued for 3 menstrual cycles. Before treatment and at the first

second and third menstrual cycles after the treatment

visual analogue score (VAS) of pain was used for dysmenorrheal. Before AND after the treatment

scores of symptoms

signs

Qi stagnation and blood stasis syndrome and endometriosis were scored by endometriosis health profile-5 (EHP-5). And hemorheology was detected

and levels of matrix metalloproteinases-2 (MMP-2)

MMP-9

tumor necrosis factor-

(TNF-

)

interleukin-1 (IL-1)

prostaglandin E

(PGE

)

prostaglandin F

(PGF

) and substance P (SP) were detected.

Result:

By rank sum test

the clinical effect of disease in observation group was better than that in control group (

=2.198

0.05). At the first

second and third menstrual cycles

score of VAS was lower than that in control group (

0.01). After treatment

scores of symptoms

signs

Qi stagnation and blood stasis syndrome and EHP-5 were lower than those in control group (

0.01). And the ameliorate of hemorheological indices

such as the whole blood viscosity (high shear and low shear)

plasma viscosity

erythrocyte sedimentation rate and platelet aggregation rate

were all better than those in control group (

0.01). And levels of MMP-2

MMP-9

TNF-

IL-1

PGF

and SP were lower than those in control group (

0.01)

whereas level of PGE

was higher than that in control group (

0.01).

Conclusion:

In addition to treatment of progestogen

Dahuang Zhechong Wan can relieve pelvic pain

improve quality of life and clinical effect

and regulate levels of prostaglandins

matrix metalloproteinases and proinflammatory factors.

关键词

Keywords

references

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