Clinical Efficacy of Modified Xiao Wuweizitang Combined with Massage Manipulation on Chronic Post-infection Cough

Lan-xuan WANG; Hai-ling LUO; He-qiu RUAN

doi:10.13422/j.cnki.syfjx.20191234

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Clinical Efficacy of Modified Xiao Wuweizitang Combined with Massage Manipulation on Chronic Post-infection Cough

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Modified Xiao Wuweizitang Combined with Massage Manipulation on Chronic Post-infection Cough
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 16, Pages: 85-90(2019)
- 作者机构：
  
  1.海南省人民医院，海口　 570311；
  2.海南省儿童医院，海口　 570311
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191234
  CLC： R72; R272; R245; R289
- Received：07 January 2019，
  
  Published Online：31 January 2019，
  
  Published：20 August 2019
- 稿件说明：
移动端阅览
Lan-xuan WANG, Hai-ling LUO, He-qiu RUAN. Clinical Efficacy of Modified Xiao Wuweizitang Combined with Massage Manipulation on Chronic Post-infection Cough[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 85-90.
DOI：

Lan-xuan WANG, Hai-ling LUO, He-qiu RUAN. Clinical Efficacy of Modified Xiao Wuweizitang Combined with Massage Manipulation on Chronic Post-infection Cough[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 85-90. DOI： 10.13422/j.cnki.syfjx.20191234.

摘要

目的：

观察小五味子汤加减配合推拿手法治疗小儿慢性感染后咳嗽(风邪伏肺证)的疗效及对患儿免疫功能和痰上清液炎症因子的影响。

方法：

将135例患儿采用随机按数字表法分为对照组和观察组。对照组59 例采用苏黄止咳胶囊，3～6岁，1粒/次；6～12岁，2粒/次，3次/d；配合推拿手法治疗，1次/d。观察组63例，采用小五味子汤加减内服和推拿手法治疗。两组疗程均为连续治疗10 d。于治疗前和治疗后5，10 d进行咳嗽视觉模拟评分(VAS)，咳嗽症状积分和风邪伏肺证评分；进行治疗前后莱塞斯特咳嗽问卷(LCQ)评分；检测治疗前后CD3

＋

，CD4

＋

，CD8

＋

水平，计算CD4

＋

/CD8

＋

；检测治疗前后痰上清白细胞介素-8(IL-8)，IL-4，肿瘤坏死因子-

(TNF-

)和P 物质(SP)和降钙素原基因相关肽(CGRP)水平。

结果：

观察组患儿在治疗后5 d和治疗后10 d咳嗽VAS评分、咳嗽症状积分和风邪伏肺证积分均低于对照组(

0.01)；观察组临床疗效优于对照组(

＝7.513，

0.01)；观察组咳嗽消失率57.81%，高于对照组的38.98%(

＝4.356，

0.05)；观察组平均咳嗽消失时间短于对照组(

0.01)；观察组LCQ问卷各维度和LCQ总分均高于对照组(

0.01)；观察组患儿痰上清液中TNF-

，IL-8，IL-4，CGRP和SP水平均低于对照组(

0.01)。

结论：

小五味子汤加减联合推拿手法治疗小儿慢性感染后咳嗽，患儿可减轻咳嗽症状，缩短咳嗽病程，提高咳嗽消失率，提高患儿的生活质量，临床疗效显著，并能起到调节患儿免疫功能，减轻气道炎症反应和气道高反应、降低咳嗽反射敏感性的作用。

Abstract

Objective:

To observe the effect of modified Xiao Wuweizitang combined with massage manipulation on chronic post-infection cough (syndrome of wind-pathogenic pulmonary embedding)

and immunity and inflammatory factors.

Method:

One hundred and thirty-five patients were randomly divided into control group and observation group by random number table. Patients (59 cases) in control group got Suhuang Zhike capsules

1 granule/time for 3 to 6-year-old children

2 granules/time

3 times/days for 6 to 12-year-old children

and massage manipulation

1 time/day. Patients (63 cases) in observation group got modified Xiao Wuweizitang combined with massage manipulation. A course of treatment was 10 days. Before treatment

and at the 5

and 10

day after treatment

visual analogue score of cough (VAS)

cough symptom

syndrome of wind-pathogenic pulmonary embedding and leicester cough questionnaire (LCQ) were scored. And levels of CD3

CD4

CD8

CD4

/ CD8

interleukin-8

IL-4

tumor necrosis factor-

(TNF-

)

substance P (SP) and calcitonin gene related peptide (CGRP) were detected.

Result:

At the 5

and 10

day after treatment

scores of VAS

cough symptom and syndrome of wind-pathogenic pulmonary embedding in observation group were lower than those in control group (

0.01)

and the clinical efficacy was superior to that in control group (

=7.513

0.01). The disappearance rate of cough in observation group was 57.81%

which was higher than 38.98%in control group (

=4.356

0.05). And the average time of disappearance of cough was shorter than that in control group (

0.01). Scores of LCQ questionnaire (physiology

psychology and society) and the total score were higher than those in control group (

0.01)

and levels of TNF-

IL-8

IL-4

CGRP and SP were lower than those in control group (

0.01).

Conclusion:

Modified Xiao Wuweizitang combined with massage manipulation can relieve cough symptom

shorten the cough course

increase rate of the disappearance of cough

improve the quality of life of children

regulate immune function of children

reduce airway inflammation

airway hyperresponsiveness and cough reflex sensitivity.

关键词

Keywords

references

中华医学会儿科学分会呼吸学组慢性咳嗽协作组．中国儿童慢性咳嗽诊断与治疗指南(2013年修订) [J]．中华儿科杂志， 2014 ， 52 ( 3 )： 184 - 188 ．

马文建，鲁玉芬，刘永新，等．小儿肺咳颗粒治疗儿童感染后咳嗽的疗效与作用机制 [J]．中国实验方剂学杂志， 2017 ， 23 ( 14 )： 204 - 209 ．

翁泽林，江文文，郑燕霞，等．儿童慢性咳嗽279例常见病因与危险因素分析 [J]．疑难病杂志， 2017 ， 16 ( 2 )： 172 - 176 ．

中华医学会呼吸病学分会哮喘学组．咳嗽的诊断与治疗指南(2015) [J]．中华结核和呼吸杂志， 2016 ， 39 ( 5 )： 323 - 354 ．

史利卿，林彬，马建岭，等．感染后咳嗽的中医证因特点初探 [J]．中华中医药杂志， 2016 ， 31 ( 2 )： 595 - 597 ．

黄维．温肺散寒化痰止咳类中药治疗肺部感染后咳嗽 [J]．吉林中医药， 2018 ， 38 ( 9 )： 1027 - 1029 ．

付杰娜，徐淑玲，尹昊．小儿推拿治疗儿童感冒后咳嗽64例 [J]．广西中医药大学学报， 2015 ， 18 ( 2 )： 25 - 26 ．

陈延之，高文铸．小品方 [M]．北京：中国中医药出版社， 1995 ： 43 - 44 ．

朱乐姗，张军．《小品方》治疗咳嗽用药规律探析 [J]．中国民间疗法， 2011 ， 19 ( 12 )： 7 - 8 ．

Birring S S , Prudon B , Carr A J , et al . Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ) [J]. Thorax , 2003 , 58 ( 4 ): 339 - 343 .

胡诣璋，赵俊，崔瑷．感染后咳嗽发病机制及治疗进展 [J]．临床药物治疗杂志， 2016 ， 14 ( 1 )： 11 - 16 ．

张硕峰，温丽娜，吴金英，等．气道高反应动物模型的建立与指标检测 [J]．中国比较医学杂志， 2014 ， 24 ( 2 )： 20 - 23 ．

何雪梅，卢育明．感染后咳嗽气道神经源性炎症水平与肺功能相关性研究 [J]．中国医学创新， 2014 ， 11 ( 19 )： 4 - 6 ．

史利卿，林彬，马建岭，等．感染后咳嗽的中医证因特点初探 [J]．中华中医药杂志， 2016 ， 31 ( 2 )： 595 - 597 ．

金耿，朱振刚．朱振刚治疗感染后咳嗽经验举隅 [J]．江西中医药， 2018 ， 49 ( 4 )： 26 - 27 ．

夏欣田．疏风宣肺止咳法与氟替卡松吸入联合治疗感染后咳嗽及对患者免疫功能的影响 [J]．吉林中医药， 2018 ( 12 )： 1398 - 1401 ．

王文，李飞侠，朱佳．宣肺止嗽汤对感染后咳嗽大鼠肺泡灌洗液中细胞因子的影响 [J]．吉林中医药， 2013 ， 33 ( 9 )： 934 - 936 ．

贾维刚，曲颖，周泉宇，等．芩百清肺浓缩丸对感染后咳嗽大鼠SP，CGRP，NEP的影响 [J]．中国中医药科技， 2018 ， 25 ( 3 )： 334 - 338 ．

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