Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine

Jing ZHU; Guang-bin SHANG; Jie ZHANG; Hui-juan SUN; Xiao-jun YAN

doi:10.13422/j.cnki.syfjx.20191321

您当前的位置：

首页 >

文章列表页 >

Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine

Review | 更新时间：2021-02-09

- Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 220-226(2019)
- 作者机构：
  
  江西中医药大学　江西省中医病因生物学重点实验室，南昌　 330004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191321
  CLC： R22; R242; R2-031; R285.5; R241.2
- Received：23 October 2018，
  
  Published Online：07 March 2019，
  
  Published：05 November 2019
- 稿件说明：
移动端阅览
Jing ZHU, Guang-bin SHANG, Jie ZHANG, et al. Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(21): 220-226.
DOI：

Jing ZHU, Guang-bin SHANG, Jie ZHANG, et al. Effect of Autophagy in Treatment of Tumors with Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(21): 220-226. DOI： 10.13422/j.cnki.syfjx.20191321.

摘要

肿瘤的根治是世界难题，患者的生活质量和生存率不高。因此寻找一个药物靶点抑制肿瘤的发生发展变得就非常有意义。近年来医学研究的热点——自噬为自体的自我吞噬，是细胞清除受损或多余细胞器，并能适应外界环境压力来获得生存，影响肿瘤细胞生存、代谢、分化、衰老和死亡等多个生物行为过程，对细胞重塑及维持细胞生存动态平衡扮演了重要角色，特别是与肿瘤发生发展变化关系密切。自噬也是把双刃剑，对于单个肿瘤细胞和整个肿瘤的效应也可能不尽相同。当肿瘤细胞自噬出现异常时，或者细胞在低氧和营养缺乏条件下，不能及时清除自身细胞内受损的物质，此时自噬有利于肿瘤细胞增殖与存活。反之，适度的自噬作为肿瘤的抑制因子，具有抗肿瘤作用。中医药防治肿瘤历史悠久，具有低毒性和多目标的优点。通过整体和局部治疗效果，在癌症中具有综合治疗效果。随着肿瘤自噬的研究日益深入，不仅西药对肿瘤自噬的研究较多，而且单味中药和中药复方在国内外研究肿瘤自噬也与日俱增，其对自噬分子机制的最新见解导致了潜在药物靶点的发现。同时中医药研究肿瘤自噬取得了一定进展。笔者就中医对自噬的认识以及中医药调节肿瘤自噬的研究进展进行综述，希望为中医药在肿瘤自噬治疗研究中提供有益的借鉴。

Abstract

The cure of tumors is a difficulty in the world

and both the quality of life and the survival rate of patients remain low. Therefore

it is very meaningful to find a drug target to inhibit the occurrence and development of tumors. In recent years

autophagy or self-phagocytosis has become a hotspot of medical research. It can remove damaged or excess organelles from cells

be survived from external environmental pressures

and affect the survival

metabolism

differentiation

aging and death of tumor cells. The biological behavioral process plays important roles in remodeling and maintaining the dynamic balance of cell survival

especially in close relations to tumor development. Autophagy is also a double-edged sword in effect on a single tumor cell and the entire tumor. When the autophagy of the tumor cells is abnormal

or the cells are unable to remove the damaged substances in time under the conditions of hypoxia and nutrient deficiency

autophagy is beneficial to the proliferation and survival of the tumor cells. Contrarily

moderate autophagy acts as an inhibitor of tumors and has an anti-tumor effect. Traditional Chinese medicine (TCM) has a long history of controlling tumors

with the advantages of low toxicity and multiple targets. Through overall and local therapies

it has a comprehensive therapeutic effect in cancer. With the deepening of tumor autophagy research

in addition to western medicine researches on tumor autophagy

there are also domestic and foreign researches on the autophagy in single herb and TCM compounds. The latest insights into the molecular mechanism of autophagy have led to the discovery of potential drug targets. At the same time

TCM researches have made some progress in tumor autophagy. The authors review the research progress of autophagy in TCM and the research progress of effect of TCM in regulating tumor autophagy

in the hopes to provide useful reference for effect of TCM in the treatment of autophagy.

关键词

Keywords

references

Levine B , Klionsky D J . Development by self-digestion: molecular mechanisms and biological functions of autophagy [J]. Dev Cell , 2004 , 6 ( 4 ): 463 - 477 .

鲍家宽，潘磊，陈培丰，等．细胞自噬的发生机制及中医药对其干预作用进展 [J]．上海中医药杂志， 2016 ， 50 ( 10 )： 99 - 102 ．

LI J L , HAN S L , FAN X . Modulating autophagy: a strategy for cancer therapy [J]. Chin J Cancer , 2011 , 30 ( 10 ): 655 - 668 .

Shintani T , Klionky D J . Autophagy in health and disease: a double-edged sword [J]. Sience , 2004 , 306 ( 5698 ): 990 - 995 .

Mizushima N , Levine B , Cuervo A M , et al . Autophagy fights disease through cellular self digestion [J]. Nature , 2008 , 451 ( 7182 ): 1069 - 1075 .

李玲，徐小洁，叶棋浓，等．细胞自噬与肿瘤 [J]．中国生物化学与分子生物学报， 2013 ， 29 ( 11 )： 995 - 1001 ．

Yan L , Vatner D E , Kim S J , et al . Autophagy in chronically ischemic myocardium [J]. Proc Natl Acad Sci USA , 2005 , 102 ( 39 ): 13807 - 13812 .

刘虹，邵荣光．自噬在肿瘤发生与发展过程中的调节作用 [J]．药学学报， 2016 ， 51 ( 1 )： 23 - 28 ．

Wilde L , Tanson K , Curry J , et al . Autophagy in cancer: a complex relationship [J]. Biochem J , 2018 , 475 ( 11 ): 1939 - 1954 .

李欢，苗明三．自噬及中医药调控自噬在治疗和防治疾病中的研究进展 [J]．中国实验方剂学杂志， 2018 ， 24 ( 20 )： 200 - 207 ．

JING S L , GUAN Y D , CHEN X S et al . Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway [J]. Acta Pharmacologica Sin , 2018 , doi: 10.1038/s41401-018-0165-9 http://doi.org/10.1038/s41401-018-0165-9 .

黄贵华，纪云西，吴大力，等．细胞自噬与中医气虚痰瘀关系探讨 [J]．中医杂志， 2011 ， 52 ( 20 )： 1717 - 1719 ．

郭旭堂，梁健芬，张新博．从痰瘀机制探讨自噬在帕金森病发展中的作用 [J]．中华中医药杂志， 2015 ， 30 ( 4 )： 1201 - 1204 ．

胡朋言，王伟，梁雪，等．细胞自噬与相关中医辨证体系的研究进展 [J]．中华中医药学刊， 2018 ， 36 ( 9 )： 2217 - 2219 ．

王志丹，贾连群，宋囡，等．从阴阳自和角度论肝脏脂质代谢与细胞自噬的关系 [J]．时珍国医国药， 2017 ， 28 ( 4 )： 924 - 925 ．

韦云，刘剑刚，李浩，等．从中医阴阳理论探讨神经细胞自噬现象对阿尔茨海默病的影响 [J]．中医杂志， 2013 ， 54 ( 13 )： 1085 - 1087 ．

李秀惠，丁剑波．细胞自噬与乙型肝炎病毒及中医药关系的研究进展 [J]．中西医结合肝病杂志， 2012 ， 22 ( 3 )： 129 - 132 ．

周江霞，敖海清，高寒．从慢性心理应激损伤与细胞自噬角度探讨肝主疏泄的功能实质 [J]．新中医， 2014 ， 46 ( 7 )： 1 - 3 ．

黎颖贤，敖海清．从微观角度探究细胞自噬与肝主疏泄功能相关性 [J]．辽宁中医药大学学报， 2016 ， 18 ( 2 )： 45 - 47 ．

苗久旺，荆雪宁，高荧，等．自噬对双去甲氧基姜黄素诱导肝癌HepG2细胞凋亡作用的影响 [J]．中国实验方剂学杂志， 2018 ， 24 ( 17 )： 167 - 171 ．

Opipari A W , TAN L , Boitano A E , et al . Resveratrol-induced autophagocytosis in ovarian cancer cells [J]. Cancer Res , 2004 , 64 ( 2 ): 696 - 703 .

胡火军，黄益玲，汪雷，等．白藜芦醇对人脑胶质瘤U87细胞自噬的影响 [J]．重庆医学， 2016 ， 45 ( 23 )： 3190 - 3192 ．

Tomas-Hernandez S , Blanco J , Rojas C , et al . Resveratrol potently counterats quercetin starvation-Induced autophagy and sensitizes HepG2 cancer cells to apoptosis [J]. Mol Nutr Food Res , 2018 , 62 ( 5 ): 1 - 40 .

CHANG C H , LEE C Y , LU C C , et al . Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: a key role of AMPK and Akt/mTOR signaling [J]. Int J Oncol , 2017 , 50 ( 3 ): 873 - 882 .

MIAO Q , BI L L , LI X , et al . Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: Roles of apoptosis and autophagy [J]. Int J Mol Sci , 2013 , 14 ( 1 ): 1370 - 1382 .

SHENG X , ZHU P , QIN J , et al . The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin [J]. Oncol Rep , 2018 , 39 ( 6 ): 2931 - 2941 .

ZHAO H , LI Q , PANG J , et al . Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress [J]. Biol Open , 2017 , 6 ( 10 ): 1416 - 1422 .

XIE C M , CHAN W Y , YU S , et al . Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation [J]. Free Radic Biol Med , 2011 , 51 ( 7 ): 1365 - 1375 .

LIU F , GAO S , YANG Y , et al . Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway [J]. Oncol Rep , 2018 , 39 ( 3 ): 1523 - 1531 .

ZHU Y , BU S . Curcumin induces autophagy, apoptosis, and cell cycle arrest in human pancreatic cancer cells [J]. Evid Based Complement Alternat Med , 2017 , doi: 10.1155/2017/5787218 http://doi.org/10.1155/2017/5787218 .

FU H , WANG C , YANG D , et al . Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling [J]. J Cell Physiol , 2018 , 233 ( 6 ): 4634 - 4642 .

GUAN F , DING Y , ZhANG Y , et al . Curcumin suppresses proliferation and migration of MDA-MB-231 breast cancer cells through autophagy-dependent Akt degradation [J]. PLoS One , 2017 , 11 ( 1 ): 1 - 18 .

CUI B , YU J M C . Autophagy: a new pathway for traditional Chinese medicine [J]. J Asian Nat Prod Res , 2018 , 20 ( 1 ): 14 - 26 .

WU J , HU G , DONG Y , et al . Matrine induces Akt/mTOR signalling inhibition-mediated autophagy and apoptosis in acute myeloid leukaemia cells [J]. J Cell Mol Med , 2017 , 21 ( 6 ): 1171 - 1181 .

ZHANG J Q , LI Y M , LIU T . Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy [J]. World J Gastroenterol , 2010 , 16 ( 34 ): 4281 - 4290 .

张军强．苦参碱诱导胃癌细胞自噬和凋亡的机制研究 [D]．兰州：兰州大学， 2013 ．

周开宇，吉海龙，毛天明，等．苦参碱体外对人髓母细胞瘤D341细胞增殖、凋亡和自噬的作用 [J]．中国药理学与毒理学杂志， 2015 ， 29 ( 2 )： 240 - 246 ．

WANG Y , LUO Q , HE X , et al . Emodin induces apoptosis of colon cancer cells via induction of autophagy in a ROS-dependent manner [J]. Oncol Res , 2017 , 8 ( 2 ): 83 - 91 .

TU P , HUANG Q , OU Y , et al . Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG-63 through the ROS/JNK signaling pathway [J]. Oncol Rep , 2016 , 35 ( 6 ): 3209 - 3215 .

朱元章，张贵彪，朱国福．中药复方抗肿瘤机制研究进展 [J]．中国实验方剂学杂志， 2017 ， 23 ( 16 )： 227 - 234 ．

胡新，陈卫平，颜晓静，等．凉血化瘀方对肝细胞损伤中自噬与凋亡相关蛋白的影响 [J]．南京中医药大学学报， 2013 ， 29 ( 5 )： 455 - 458 ．

吴坚，刘沈林，张星星，等．健脾养正消癥方对裸鼠胃癌皮下移植瘤细胞凋亡的影响及自噬机制的实验研究 [J]．中国中西医结合杂志， 2015 ， 35 ( 9 )： 1113 - 1118 ．

CHEN S T , LEE T Y , TAI T H , et al . The traditional Chinese medicine Danggui Buxue Tang sensitizes colorectal cancer cells to chemoradio therapy [J]. Molecules , 2016 , 21 ( 12 ): 1677 - 1693 .

MA C , WANG X , YU M , et al . Inhibitory effects of Guben Yiliu Formula Ⅱ (Ⅱ) and its blood activation prescriptions on the growth of MCF-7 human breast cancer xenografts in nude mice [J]. Chin J Integr Med , 2014 , doi: 10.1007/s11655-014-1992-2 http://doi.org/10.1007/s11655-014-1992-2 .

YU N , XIONG Y , WANG C , et al . Bu-Zhong-Yi-Qi decoction, the water extract of Chinese traditional herbal medicine, enhances cisplatin cytotoxicity in A549/DDP cells through Induction of apoptosis and autophagy [J]. Biomed Res Int , 2017 , doi: 10.1155/2017/3692797 http://doi.org/10.1155/2017/3692797 .

JIA L J , HUANG S , YIN X R , et al . Quercetin suppresses the mobility of breast cancer by suppressing glycolysisthrough Akt-mTOR pathway mediated autophagy induction [J]. Life Sci , 2018 , 208 ( 1 ): 123 - 130 .

LIU T , XU L , WANG C , et al . Alleviation of hepatic fibrosis and autophagy via inhibition of transforming growth factor-β1/Smads pathway through shikonin [J]. J Gastroenterol Hepatol , 2019 , 34 ( 1 ): 263 - 276 .

ZHAO W , PENG F , SHU M , et al . Isogambogenic acid inhibits the growth of glioma through activation of the AMPK-mTOR pathway [J]. Cell Physiol Biochem , 2017 , 44 ( 4 ): 1381 - 1395 .

倪晓辰，赵志红，马永良，等．粉防己碱对膀胱癌T24细胞的凋亡诱导和自噬抑制作用 [J]．肿瘤， 2014 ， 34 ( 12 )： 1109 - 1114 ．

CHEN J , ZHANG Z Q , SONG J , et al . 18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma [J]. Sci Rep , 2018 , 8 ( 1 ): 9365 .

SONG L , WANG Z , WANG Y , et al . Natural cyclopeptide RA-XII, a new autophagy inhibitor, suppresses protective autophagy for enhancing apoptosis through AMPK/mTOR/P70S6K pathways in HepG2 cells [J]. Molecules , 2017 , 22 ( 11 ): 1 - 16 .

张瑞娟，许建华，孙珏，等．肠胃清方对人结肠癌HCT116/L-OHP裸鼠皮下移植瘤miR-30a/Beclin1通路的影响 [J]．世界华人消化杂志， 2017 ， 25 ( 12 )： 1061 - 1070 ．

包晓霞，唐瑶，鲁周南，等．清热解毒方连花汤提取物诱导子宫内膜癌HEC-1A及Ishikawa细胞自噬的作用及其机制研究 [J]．中国妇产科临床杂志， 2018 ， 19 ( 2 )： 150 - 154 ．

仲飞，戴一，张锋利，等．西黄丸含药血清对人肝癌BEL-7404细胞增殖和凋亡及自噬的影响 [J]．中华肿瘤防治杂志， 2015 ， 22 ( 22 )： 1735 - 1740 ．

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Progress in Research on Anticancer Mechanism of Apigenin

Improved Learning and Memory in Sleep-deprived Mice by Anmeidan via Cellular Autophagy Regulation Through PI3K/Akt/mTOR Signaling Pathway

Nano-traditional Chinese Medicine-Induced Cuproptosis and Ferroptosis in Tumor Resistance： A Review

Effect of Yishen Huayu Prescription on Autophagy of Transdifferentiated TCMK-1 Cells Based on SIRT1/FoxO1 Pathway

Traditional Chinese Medicine Ameliorates Tumor Chemotherapy Resistance： A Review

Related Author

XIN Li-li

ZHANG Xu

GONG Jie-ning

LIU Huizhen

ZHANG Yini

CHEN Yumeng

XIAO Chunfeng

ZHANG Xuesong

Related Institution

School of Traditional Chinese Medicine， Hubei University of Chinese Medicine

Engineering Research Center of Traditional Chinese Medicine Protection Technology and New Product Development for the Elderly Brain Health， Ministry of Education， Hubei University of Chinese Medicine

School of Basic Medical Sciences， Hubei University of Chinese Medicine

School of Pharmaceutics， Hubei University of Chinese Medicine

Hubei Shizhen Laboratory

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰