Clinical Efficacy and 5-HT, VIP Levels of Hegan Granule in Treating Non-erosive Reflux Disease of Liver Depression and Spleen Deficiency

Li AN; Xiao-jing XIE; Ya-jie LI; Yue HUANG; Hong QUAN

doi:10.13422/j.cnki.syfjx.20191330

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Clinical Efficacy and 5-HT, VIP Levels of Hegan Granule in Treating Non-erosive Reflux Disease of Liver Depression and Spleen Deficiency

Clinic | 更新时间：2021-02-09

- Clinical Efficacy and 5-HT, VIP Levels of Hegan Granule in Treating Non-erosive Reflux Disease of Liver Depression and Spleen Deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 12, Pages: 110-114(2019)
- 作者机构：
  
  首都医科大学　附属北京朝阳医院，北京　 100020
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191330
  CLC： R22; R242; R2-031; R287
- Received：01 August 2019，
  
  Published Online：20 March 2019，
  
  Published：20 June 2019
- 稿件说明：
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Li AN, Xiao-jing XIE, Ya-jie LI, et al. Clinical Efficacy and 5-HT, VIP Levels of Hegan Granule in Treating Non-erosive Reflux Disease of Liver Depression and Spleen Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 110-114.
DOI：

Li AN, Xiao-jing XIE, Ya-jie LI, et al. Clinical Efficacy and 5-HT, VIP Levels of Hegan Granule in Treating Non-erosive Reflux Disease of Liver Depression and Spleen Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(12): 110-114. DOI： 10.13422/j.cnki.syfjx.20191330.

摘要

目的：

观察和肝颗粒治疗肝郁脾虚型非糜烂性反流病患者的临床疗效及对患者生活质量，5-羟色胺(5-HT)，血管活性肠肽(VIP)水平的影响。

方法：

将肝郁脾虚型非糜烂性反流病患者随机分为治疗组32例和对照组33例，治疗组采用和肝颗粒10 g/袋，每次1袋，每日2次，餐后口服。对照组采用奥美拉唑肠溶片20 mg/粒，每日2次，餐前口服。两组疗程均为8周。观察两组治疗前后中医症状总积分及SF-36健康量表评分及5-HT，VIP水平。

结果：

两组患者中医疗效比较，治疗组、对照组中医疗效总有效率分别为87.5%，81.8%，治疗组优于对照组(

0.05)；治疗后治疗组在特殊症状、次要症状方面改善优于对照组(

0.05)；在主要症状方面两组疗效相当；治疗后治疗组SF-36健康量表在生理职能、总体健康、活力、社会功能、情感职能、心理健康6个维度评分均较高于对照组(

0.05)；治疗后两组患者5-HT，VIP水平均降低，治疗组低于对照组(

0.05)。

结论：

和肝颗粒治疗肝郁脾虚型非糜烂性反流病患者具有较好的临床疗效，能够改善患者的中医症状，并能提高患者的生活质量，降低食管内脏敏感性。

Abstract

Objective:

To observe the clinical efficacy of Hegan granule in the treatment of non-erosive reflux disease with liver stagnation and spleen deficiency syndrome and its effect on quality of life

5-hydroxytryptamine (5-HT) and vasoactive intestinal peptide (VIP) level.

Method:

Patients with non-erosive reflux disease of liver stagnation and spleen deficiency were randomly divided into treatment group (32 cases) and control group (33 cases). The treatment group was orally given Hegan granules after meal

10 g/bag

1 bag/time

2 times/day. The control group was orally given with omeprazole enteric-coated tablets twice daily

20 mg/grain. Both groups were treated for 8 weeks. The total scores of traditional Chinese medicine (TCM) symptoms

SF-36 health scale scores

5-HT and VIP levels were observed before and after treatment.

Result:

The medical efficacy of the two groups was 87.5%and 81.8%in the treatment group and the control group

respectively. The treatment group was superior to control group (

0.05). The treatment group had special symptoms and secondary symptoms after treatment

with better improvements than control group (

0.05). The efficacy of the two groups was comparable in the main symptoms

after the treatment

the SF-36 health scale of treatment group in physiological function

overall health

vitality

social function

emotional function and mental health were higher than those in control group (

0.05). The levels of 5-HT and VIP in two groups were lower after treatment

and treatment group was significantly lower than control group (

0.05).

Conclusion:

Hegan granule has a good clinical efficacy in treating patients with non-erosive reflux disease and liver stagnation and spleen deficiency. It can significantly alleviate the symptoms of TCM

improve the quality of life of patients

and reduce the sensitivity of esophageal viscera.

关键词

Keywords

references

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