Optimization of Electromagnetic Cracking Extraction Technology of Baicalin in Scutellariae Radix by Response Surface Methodology

Ren-guang WANG; Ai-ling JIA; Zhi-dong QIU; Jing-yao YANG; Xin-shu ZHANG; Ji-qi YANG

doi:10.13422/j.cnki.syfjx.20191349

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Optimization of Electromagnetic Cracking Extraction Technology of Baicalin in Scutellariae Radix by Response Surface Methodology

Pharmacy and Processing | 更新时间：2021-02-09

- Optimization of Electromagnetic Cracking Extraction Technology of Baicalin in Scutellariae Radix by Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 106-111(2019)
- 作者机构：
  
  1.长春中医药大学　中药有效成分省部共建教育部重点实验室，长春　 130117；
  2.成都中医药大学　药学院，成都　 611137
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191349
  CLC： R22; R94; R28; C37; O657.7
- Received：23 January 2019，
  
  Published Online：19 March 2019，
  
  Published：05 November 2019
- 稿件说明：
移动端阅览
Ren-guang WANG, Ai-ling JIA, Zhi-dong QIU, et al. Optimization of Electromagnetic Cracking Extraction Technology of Baicalin in Scutellariae Radix by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(21): 106-111.
DOI：

Ren-guang WANG, Ai-ling JIA, Zhi-dong QIU, et al. Optimization of Electromagnetic Cracking Extraction Technology of Baicalin in Scutellariae Radix by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(21): 106-111. DOI： 10.13422/j.cnki.syfjx.20191349.

摘要

目的：

建立电磁裂解水提黄芩中黄芩苷的最佳工艺条件，为该提取技术的推广与应用提供参考。

方法：

在单因素试验基础上，选取提取时间、物料粒度、液料比3个因素进行Box-Behnken中心组合设计，以黄芩苷提取率为指标，利用响应面法优化黄芩苷电磁裂解提取的最佳工艺参数，并与超声法、乙醇回流法和煎煮法进行比较。

结果：

最佳工艺条件为提取时间2.41 min，物料粒度过100目筛，液料比33 mL·g

－1

；在该条件下，黄芩苷提取率12.21%。运用乙醇回流法、煎煮法和超声法提取时，黄芩苷的提取率分别为12.91%，12.62%，11.61%。电磁裂解法提取黄芩苷的得率与其他几种常规提取方法接近，但提取时间明显缩短。

结论：

作为一种新兴的中药提取技术，电磁裂解提取具有快速高效、省时节能、绿色环保等优点，可为黄芩苷的工业化提取提供新方法。

Abstract

Objective:

To optimize the extraction conditions of baicalin from Scutellariae Radix by electromagnetic pyrolysis.

Method:

Based on single factor experiments

taking extraction time

material size and liquid-material ratio as factors

yield of baicalin as index

extraction parameters were optimized by response surface methodology

and compared with ultrasonic method

ethanol refluxing method and decoction method.

Result:

The optimal extraction conditions were as follows: extraction time of 2.41 min

material size of 100 mesh

liquid-material ratio of 33 mL·g

-1

. Under these conditions

the yield of baicalin was 12.21%. The yields of baicalin by ethanol refluxing method

decoction method and ultrasonic method were 12.91%

12.62%and 11.61%

respectively. The yield of baicalin by electromagnetic cracking extraction was close to several other conventional extraction methods

and the extraction time was significantly shortened.

Conclusion:

As a novel extraction technology of traditional Chinese medicine

electromagnetic cracking extraction has the advantages of high efficiency

energy and time saving

green environmental protection

etc. And it can provide a new method for the industrial extraction of baicalin.

关键词

Keywords

references

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