Analysis on Pathogenesis of Diabetes Mellitus Based on Theory of Ascending and Descending of Qi Movement of Gut Microbiota

Jian-wei ZHU; Yu-lin LENG; Xiu-juan ZHOU; Kai-shan WEI; Xiao-xu FU; Chun-guang XIE

doi:10.13422/j.cnki.syfjx.20191422

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Analysis on Pathogenesis of Diabetes Mellitus Based on Theory of Ascending and Descending of Qi Movement of Gut Microbiota

Academic Discussion | 更新时间：2021-02-09

- Analysis on Pathogenesis of Diabetes Mellitus Based on Theory of Ascending and Descending of Qi Movement of Gut Microbiota
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 21, Pages: 189-195(2019)
- 作者机构：
  
  1.成都中医药大学，成都　 610072;
  2.成都中医药大学　附属医院，成都　 610072
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191422
  CLC： R22; R242; R2-031; R285.5;R287
- Received：16 November 2018，
  
  Published Online：03 April 2019，
  
  Published：05 November 2019
- 稿件说明：
移动端阅览
Jian-wei ZHU, Yu-lin LENG, Xiu-juan ZHOU, et al. Analysis on Pathogenesis of Diabetes Mellitus Based on Theory of Ascending and Descending of Qi Movement of Gut Microbiota[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(21): 189-195.
DOI：

Jian-wei ZHU, Yu-lin LENG, Xiu-juan ZHOU, et al. Analysis on Pathogenesis of Diabetes Mellitus Based on Theory of Ascending and Descending of Qi Movement of Gut Microbiota[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(21): 189-195. DOI： 10.13422/j.cnki.syfjx.20191422.

摘要

肠道菌群及其代谢产物之间的稳态对维持宿主的正常代谢和生理功能起着关键作用，这也与中医认为“气机升降”运动维持着人体脏腑气血津液等功能作用的发挥，使机体实现动态平衡的观点有许多相似之处。越来越多研究证实肠道微生物功能失调可影响宿主信号传导途径，从而导致糖尿病及其并发症的发生发展，而肠道关键菌的调控已逐渐成为糖尿病及其并发症防治的重要新靶点。气机升降理论立足于“动态平衡”，将气机升降与各脏腑组织的功能活动、精微物质的输布、能量的代谢等环节紧密渗透连贯，高度概括了机体生理活动及病理变化的基本表现形式。气机升降障碍是导致机体各系统内环境失衡的主要原因。本文藉气机升降理论，动态阐释肠道微生态失衡在糖尿病的病理生理机制中的病机演变规律。笔者认为气机升降有序是维持肠道微生态平衡及物质代谢“内稳态”的必要条件。若气机升降失权，金失敛降，土不散精，木郁不疏，元阳虚损，则清阳不升、浊阴下陷，肠腑受盛、传道功能失常；这种失衡状态进一步发展会加剧气血津液代谢障碍，使精不归正化，郁滞化火而变生糖尿病。因此，在气机升降理论指导下，探讨肠道菌群及其代谢产物对糖尿病的调节机制，将有助于揭示中医药通过调节肠道菌群，维持机体物质代谢“内稳态”的科学内涵。

Abstract

The gut microbiota and its metabolites play a critical role on health maintenance

because they are involved in the absorption and metabolism of nutrients in the human bodies. This is also similar to traditional Chinese medicine (TCM) view that the ascending and descending of Qi movement affects Yin-Yang

Qi-blood

pneuma and body fluid

viscera and meridians of our bodies. More and more studies have demonstrated that gut microbiota is closely related to the development and progression of diabetes and its complications. Gut microbiota disorder could affect host metabolic signaling pathways

thereby promoting the formation and development of diabetes. The smooth ascending and descending of Qi movement is the basic form of maintaining host metabolic homeostasis

whose dysfunction however can lead to internal environment disturbance. Based on the theory of ascending and descending of Qi movement

this paper focuses on the pathogenesis of imbalanced intestinal flora in the process of the induction of diabetes mellitus from a dynamic perspective. It is assumed that the imbalance of Qi ascending and descending may act as a trigger for such symptoms as lung Qi impairment

spleen deficiency to dissipating essence

liver Qi stagnation and kidney Yang deficiency. Under this circumstance

gut microbiota will be out of balance

which will further lead to the nutrient substance metabolic disturbance in the body

and thus induce diabetes. Thus

it is significant to explore the regulatory mechanism of gut microbiota and its metabolites on diabetes based on the theory of ascending and descending of Qi movement

so as to reveal the scientific connotation of TCM in regulating substance metabolism homeostasis in the body.

关键词

Keywords

references

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