Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-<italic style="font-style: italic">β</italic><sub>1</sub> in Serum of Senile Asthma on Persistent Stage

Lin JIA; Bo-lin LI; Li-ying WEI; Xuan ZHANG; Lei WU

doi:10.13422/j.cnki.syfjx.20191423

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Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β₁ in Serum of Senile Asthma on Persistent Stage

Clinic | 更新时间：2021-02-09

- Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β₁ in Serum of Senile Asthma on Persistent Stage
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 14, Pages: 119-124(2019)
- 作者机构：
  
  河北省中医院，石家庄　 050031
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191423
  CLC： R22; R242; R2-031;R287
- Received：03 December 2018，
  
  Published Online：04 April 2019，
  
  Published：20 July 2019
- 稿件说明：
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Lin JIA, Bo-lin LI, Li-ying WEI, et al. Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β₁ in Serum of Senile Asthma on Persistent Stage[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(14): 119-124.
DOI：

Lin JIA, Bo-lin LI, Li-ying WEI, et al. Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β₁ in Serum of Senile Asthma on Persistent Stage[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(14): 119-124. DOI： 10.13422/j.cnki.syfjx.20191423.

摘要

目的：

探讨金水六君煎加味联合沙美特罗替卡松粉吸入剂治疗慢性持续期老年哮喘患者的临床疗效及对血清血管内皮生长因子(vascular endothelial growth factor，VEGF)，转化生长因子-

(transforming growth factor-

，TGF-

)的影响。

方法：

选取符合纳入标准的老年哮喘患者100例，随机数字表法分为对照组和治疗组。每组各50例。两组均根据病情给予氧疗、化痰、抗感染等措施，并给予沙美特罗替卡松粉吸入剂50 μg·(500 μg)

－1

，1吸/次，2次/d。同时，对照组加用茶碱缓释胶囊0.1 g，

bid

，治疗组加用金水六君煎加味治疗。两组疗程均为8周。观察两组患者的中医证候疗效，治疗前后、治疗后3，6个月两组患者的哮喘控制测试(asthma control test，ACT)得分，治疗前后两组患者的肺功能及血清VEGF，TGF-

水平。评价两组治疗期间的用药安全性。

结果：

治疗组的总有效率高于对照组(

0.05)。与对照组比较，治疗后、治疗后3，6个月治疗组ACT得分均明显升高(

0.05)。治疗后与对照组比较，治疗组的呼气流量峰值(peak expiratory flow，PEF)变异率和血清VEGF，TGF-

水平均明显降低(

0.05)；1 s用力呼气量占预计值百分比(percentage of forced expiratory volume in first second and its predicted value，FEV

%)，第1秒末用力呼气量占用力肺活量百分比(percentage of forced expiratory volume in first second and forced vital capacity，FEV

/FVC)均明显升高(

0.05)。治疗期间两组不良反应发生率比较，治疗组明显低于对照组(

0.05)。

结论：

与茶碱缓释胶囊联合沙美特罗替卡松粉吸入剂治疗比较，金水六君煎加味联合沙美特罗替卡松粉吸入剂治疗慢性持续期老年哮喘可更明显地提高患者的临床疗效，改善肺功能，其作用机制可能与调节血清VEGF及TGF-

水平有关。

Abstract

Objective:

To explore the clinical efficacy of modified Jinshui Liujunjian combined with salmeterol/fluticasone on senile asthma on persistent stage and its effect on vascular endothelial growth factor (VEGF) and transforming growth factor-

(TGF-

) in serum.

Method:

The 100 cases of senile asthma who met inclusion criteria were selected and divided into two equal groups by random number table: the control group and the treatment group. Patients of the two groups were given oxygen therapy

phlegm reduction

infection control and salmeterol/fluticasone 50 μg·(500 μg)

-1

. Patients in control group were given sustained release capsule of theophylline in addition to the above therapy

while patients in treatment group were given modified Jinshui Liujunjian. The course of treatment was 8 weeks. The therapeutic effectiveness of traditional Chinese medicine (TCM) syndrome between two groups was observed. Asthma control test (ACT) scores at four different time points(before and after treatment

6 months after treatment)

pulmonary function

the levels of VEGF and TGF-

in serum before and after treatment between two groups were also observed. The pharmic safety during treatment was evaluated.

Result:

The total effective rate of treatment group was significantly higher than that of control group(

0.05). Compared with that in control group

ACT scores in treatment group were significantly higher at three different time points(after treatment

3 and 6 months after treatment)(

0.05). Compared with that in control group

peak expiratory flow (PEF) variability and the levels of VEGF and TGF-

in serum in treatment group were significantly lowered after treatment(

0.05)

while the percentage of forced expiratory volume in the first second and its predicted value (FEV

and the percentage of forced expiratory volume in the first second and its forced vital capacity (FEV

/FVC) were significantly higher(

0.05). Compared with that in control group

the incidence of the untoward effect in treatment group were significantly lowered during treatment(

0.05).

Conclusion:

Modified Jinshui Liujunjian combined with Salmeterol/Fluticasone was more effective than Sustained release capsule of theophylline combined with Salmeterol/Fluticasone in improving the clinical efficacy and pulmonary function of senile asthma on the persistent stage. Its mechanism of action is probable correlated with the reduction of levels of VEGF and TGF-

in serum.

关键词

Keywords

references

SONG W J , KANG M G , CHANG Y S , et al . Epidemiology of adult asthma in Asia: toward a better understanding [J]. Asia Pac Allergy , 2014 , 4 ( 2 ): 75 - 85 .

King M J , Hanania N A . Asthma in the elderly: current knowledge and future directions [J]. Currpin Pulm Med , 2010 , 16 ( 1 ): 55 - 59 .

Louis-Philippe B . Asthma in the elderly patient [J]. Asth Res Pract , 2016 , 2 ( 1 ): 3 .

中华医学会呼吸病学分会哮喘学组．支气管哮喘防治指南(2016版) [J]．中华结核和呼吸杂志， 2016 ， 39 ( 9 )： 675 - 697 ．

中华中医药学会肺系病专业委员会，中国民族医药学会肺病分会．支气管哮喘中医证候诊断标准(2016版) [J]．中医杂志， 2016 ， 57 ( 22 )： 1978 - 1980 ．

中华人民共和国卫生部．中药新药临床研究指导原则 [M]．北京：人民卫生出版社， 2002 ： 33 - 35 ．

JIA C E , ZHANG H P , LV Y , et al . The asthma control test and asthma control questionnaire for assessing asthma control: systematic review and Meta-analysis [J]. J Allergy Clin Immunol , 2013 , 131 ( 3 ): 695 - 703 .

Chetta A , Olivieri D . Role of inhaled steroids in vascular airway remodelling in asthma and COPD [J]. Int J Endocrinol , 2012 , 2012 : 397693 .

Gomulka K , Liebhart J . Vascular endothelial growth factor-structure, function and role in airways inflammation and the clinical course of asthma [J]. Pneumonol Alergol Pol , 2009 , 77 ( 6 ): 549 - 553 .

Lopez-Guisa J M , Powers C , File D , et al . Airway epithelial cells from asthmatic children differentially express proremodeling factors [J]. J Allergy Clin Immunol , 2012 , 129 ( 4 ): 990 - 997 .

龙怀聪，王曾礼，肖邦榕，等．表皮生长因子受体对支气管哮喘大鼠气道重塑的影响 [J]．中华结核和呼吸杂志， 2004 ， 27 ( 11 )： 774 - 775 ．

Kawashima T , Yamazaki R , Matsuzawa Y , et al . Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts [J]. Eur J Pharmacol , 2012 , 696 ( 1/3 ): 120 - 129 .

YANG Y C , ZHANG N , Van Crombruggen K , et al . Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling [J]. Allergy , 2012 , 67 ( 10 ): 1193 - 1202 .

SHI Y , DONG Y , DUAN Y , et al . Substrate stiffness influences TGF-betal-induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodeling [J]. Mol Med Rep , 2013 , 7 ( 2 ): 419 - 424 .

陈文为．中医药学与自由基学说 [J]．中西医结合杂志， 1991 ， 11 ( 7 )： 427 - 429 ．

李海燕，顾超，汤杰，等．加味解痉祛风汤治疗支气管哮喘慢性持续期风哮证临床观察 [J]．新中医， 2013 ， 45 ( 1 )： 26 - 29 ．

王燕，董群．左归饮及其部分组方对老年小鼠细胞免疫功能的影响 [J]．中国免疫学杂志， 2006 ， 22 ( 9 )： 842 - 844 ．

陈彩英，詹若挺，陈蔚文．巴戟天的药理研究进展 [J]．中药新药与临床药理， 2009 ， 20 ( 3 )： 291 - 293 ．

施小山，孙智霞．黄芪注射液对支气管哮喘急性发作的疗效及对细胞免疫功能的影响 [J]．中国实验方剂学杂志， 2012 ， 18 ( 16 )： 293 - 296 ．

崔妮，史辑，贾天柱．巴戟天不同炮制品补肾壮阳作用的比较研究 [J]．中国中药杂志， 2013 ， 38 ( 22 )： 3898 - 3901 ．

李海燕，杨佩兰，黄海茵，等．全蝎-蜈蚣药对对哮喘模型大鼠气道炎症及气道重塑的影响 [J]．中国实验方剂学杂志， 2013 ， 19 ( 1 )： 206 - 210 ．

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Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β1 in Serum of Senile Asthma on Persistent Stage

DOI：10.13422/j.cnki.syfjx.20191423

摘要

Abstract

关键词

Keywords

references

Effect of Modified Jinshui Liujunjian Combined with Salmeterol/Fluticasone on VEGF and TGF-β₁ in Serum of Senile Asthma on Persistent Stage