Effect of Wenfei Zhiliudan in Treating Lung Qi Deficiency Cold Type Allergic Rhinitis and Its Mechanism

Wen-ming CHEN; Jing-bo LI; Hui-min WANG; Jun-jie WANG; Feng CHAI

doi:10.13422/j.cnki.syfjx.20191424

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Effect of Wenfei Zhiliudan in Treating Lung Qi Deficiency Cold Type Allergic Rhinitis and Its Mechanism

Clinic | 更新时间：2021-02-09

- Effect of Wenfei Zhiliudan in Treating Lung Qi Deficiency Cold Type Allergic Rhinitis and Its Mechanism
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 22, Pages: 55-59(2019)
- 作者机构：
  
  河南省中医院，郑州　 450002
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191424
  CLC： R22; R242; R2-031;R287
- Received：31 December 2018，
  
  Published Online：04 April 2019，
  
  Published：20 November 2019
- 稿件说明：
移动端阅览
Wen-ming CHEN, Jing-bo LI, Hui-min WANG, et al. Effect of Wenfei Zhiliudan in Treating Lung Qi Deficiency Cold Type Allergic Rhinitis and Its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(22): 55-59.
DOI：

Wen-ming CHEN, Jing-bo LI, Hui-min WANG, et al. Effect of Wenfei Zhiliudan in Treating Lung Qi Deficiency Cold Type Allergic Rhinitis and Its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(22): 55-59. DOI： 10.13422/j.cnki.syfjx.20191424.

摘要

目的：

观察温肺止流丹治疗肺气虚寒型变应性鼻炎的疗效及安全性。

方法：

120例患者随机分为对照组和观察组，各60例。对照组给予枸地氯雷他定＋糠酸莫米松，观察组给予温肺止流丹，疗程均为2周。观察治疗前后两组患者的生命质量问卷评分(rhino conjunctivitis quality of life questionnaire，RQLQ)，鼻部症状总评分(total nasal symptom score，TNSS)和中医辨证肺气虚寒型评分(中医量表)；分别抽取患者空腹静脉血检测血清炎症因子[肿瘤坏死因子-

(tumor necrosis factor-

，TNF-

)，

-干扰素(interferon-

，IFN-

)，白细胞介素-33(interleukin-33，IL-33)]，免疫指标[免疫球蛋白E(immunoglobulin E，IgE)，嗜酸性粒细胞(eosinophils，EOS)，嗜酸粒细胞趋化酞(eotaxin，EOT)]

的含量；比较两组总有效率和不良反应发生率。

结果：

研究期间脱落5例。观察组总有效率91.5%(54/59)，高于对照组的82.5%(47/57)(

0.05)；观察组患者RQLQ，TNSS和中医量表评分较对照组明显降低(

0.05)；观察组患者血清炎症因子(TNF-

，IFN-

，IL-33)含量较对照组明显降低(

0.05)；观察组患者血清免疫指标(IgE，EOS)含量较对照组明显降低(

0.05)，EOT含量较对照组明显升高；观察组不良反应(头痛、口干、乏力、皮疹、心悸、消化不良和肝酶升高)发生率1.7%(1/59)，低于对照组的19.3%(11/57)(

0.05)。

结论：

温肺止流丹可明显改善肺气寒虚型变应性鼻炎患者的临床症状、血清炎症因子和免疫指标，不良反应发生率低。

Abstract

Objective:

To observe the efficacy and safety of Wenfei Zhiliudan in treatment of lung Qi deficiency cold type allergic rhinitis.

Method:

A total of 120 cases were randomly divided into control group and observation group

with 60 cases in each group. The control group was given desloratadine + momethasone furoate

while observation group was given Wenfei Zhiliudan. A course of treatment was 2 weeks. The rhino conjunctivitis quality of life questionnaire (RQLQ)

total nasal symptom score (TNSS) and traditional Chinese medicine (TCM) syndrome differentiation scale for lung Qi deficiency cold (TCM scale) in two groups before and after treatment were observed. The serum inflammatory factor [tumor necrosis factor-

(TNF-

)

interferon-

(IFN-

)

interleukin-33 (IL-33)] and immune indexes [immunoglobulin E (IgE)

eosinophils (EOS)

eotaxin (EOT)]

were determined. The total effective rate and the incidence of adverse reactions were compared between two groups.

Result:

Five cases felt off during the study period. The total effective rate in observation group was 91.5%(54/59)

which was higher than 82.5%(47/57) in control group (

0.05). The RQLQ

TNSS and TCM scale scores in observation group were significantly lower than those in control group (

0.05). The serum levels of inflammatory factors (TNF-

IFN-

IL-33) in observation group were significantly lower than those in control group (

0.05). The serum levels of immune indexes (IgE

EOS) in observation group were significantly lower than those in control group (

0.05)

while EOT in observation group were significantly higher than that in control group (

0.05). The incidence of adverse reactions was 1.7%(1/59) in observation group

which was lower than 19.3%(11/57) in control group (

0.05).

Conclusion:

Wenfei Zhiliudan can significantly alleviate the clinical symptoms

serum inflammatory factors and immune indicators of lung Qi deficiency cold type allergic rhinitis

with a lower incidence of adverse reactions.

关键词

Keywords

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