Effect of Chaishao Shugan Lidan Paishitang on Inflammation, Stress Response and Gastrointestinal Function in Gallstones Patients with Chronic Cholecystitis

Jing LOU; Fei WANG; Lei ZHAO; Liu-fa HOU

doi:10.13422/j.cnki.syfjx.20191427

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Effect of Chaishao Shugan Lidan Paishitang on Inflammation, Stress Response and Gastrointestinal Function in Gallstones Patients with Chronic Cholecystitis

Clinic | 更新时间：2021-02-09

- Effect of Chaishao Shugan Lidan Paishitang on Inflammation, Stress Response and Gastrointestinal Function in Gallstones Patients with Chronic Cholecystitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 23, Pages: 86-92(2019)
- 作者机构：
  
  1.河南省中医药研究院　附属医院，郑州　 450004；
  2.赵法新名医工作室，郑州　 450004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191427
  CLC： R22; R242; R2-031;R287
- Received：03 December 2018，
  
  Published Online：03 April 2019，
  
  Published：05 December 2019
- 稿件说明：
移动端阅览
Jing LOU, Fei WANG, Lei ZHAO, et al. Effect of Chaishao Shugan Lidan Paishitang on Inflammation, Stress Response and Gastrointestinal Function in Gallstones Patients with Chronic Cholecystitis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(23): 86-92.
DOI：

Jing LOU, Fei WANG, Lei ZHAO, et al. Effect of Chaishao Shugan Lidan Paishitang on Inflammation, Stress Response and Gastrointestinal Function in Gallstones Patients with Chronic Cholecystitis[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(23): 86-92. DOI： 10.13422/j.cnki.syfjx.20191427.

摘要

目的：

探究柴芍疏肝利胆排石汤对胆结石合并慢性胆囊炎患者炎症、应激反应及胃肠功能的影响。

方法：

随机将2017年3月至2018年5月河南省中医药研究院附属医院收治的胆结石并慢性胆囊炎患者分为对照组和观察组，各65例，对照组采用口服熊去氧胆酸和甲硝唑治疗，在对照组的基础上，观察组给予柴芍疏肝利胆排石汤水煎服。治疗前后观察两组患者的中医症状评分，白细胞介素-6(IL-6)，肿瘤坏死因子-

(TNF-

)，超敏C反应蛋白(hs-CRP)，超氧化物歧化醇(SOD)，丙二醇(MDA)，糖类抗原19-9(CA19-9)，癌胚抗原(CEA)，胃动素(MOT)，胃泌素(GAS)，生长抑素(SS)，谷氨酸氨基转移酶(ALT)，门冬氨酸氨基转移酶(AST)，总胆红素(TBIL)，总胆汁酸(TBA)，总胆固醇(TC)水平，并观察两组的疗效、不良反应及复发情况。

结果：

观察组的炎症疗效、结石消融疗效、临床疗效均明显优于对照组(

＝2.329，

0.05；

＝2.686，

0.05；

＝2.940，

0.05)。观察组治疗后的右上腹隐痛、腹胀、恶心呕吐、舌质淡红症状评分低于对照组(

0.05)。观察组治疗后ALT，AST，TC，TNF-

，hs-CRP，IL-6，CEA，CA19-9，SS，MDA水平低于对照组(

0.05)，观察组治疗后MOT，GAS，SOD水平高于对照组(

0.05)，观察组和对照组复发率分别为3.17%(2/63)，14.29%(9/63)，组间复发率差异具有统计学意义(

＝5.140，

0.05)。

结论：

柴芍疏肝利胆排石汤治疗胆结石合并慢性胆囊炎的疗效较好，能缓解临床症状，抑制氧化应激反应和炎症反应，改善肝胆功能和胃肠功能，降低复发率。

Abstract

Objective:

To explore the effect of Chaishao Shugan Lidan Paishitang on inflammation

stress response and gastrointestinal function in gallstones patients with chronic cholecystitis.

Method:

Gallstones patients with chronic cholecystitis treated in our hospital from March 2017 to May 2018 were randomly divided into two groups

with 65 cases in each group. The control group was orally given ursodeoxycholic acid combined with metronidazole. In addition to the therapy of the control group

the Observation group was also given Chaishao Shugan Lidan Paishitang. Traditional Chinese medicine symptom scores

interleukin-6 (IL-6)

tumor necrosis factor-

(TNF-

)

hypersensitive C-reactive protein (hs-CRP)

superoxide disproportionation alcohol (SOD)

propylene glycol (MDA) and carbohydrate antigen 19-9 (CA19-9)

carcinoembryonic antigen (CEA)

gastric dynamic element (MOT)

gastrin-releasing (GAS) and somatostatin (SS)

alanine aminotransferase (ALT)

aspertate aminotransferase (AST)

total bilirubin (TBIL) and total bile acid (associates)

and total cholesterol (TC) levels before and after treatment were observed in two groups

and the curative effect

reactions and relapse were also observed.

Result:

The inflammatory effect

stone ablation effect and clinical effect of observation group were significantly better than those of control group (

=2.329

0.05;

=2.686

0.05;

=2.940

0.05). The scores of right upper abdominal dull pain

abdominal distension

nausea and vomiting

and pale red tongue in the observation group after treatment were lower than those in control group (

0.05). The levels of ALT

AST

TNF-

hs-CRP

IL-6

CEA

CA19-9

SS and MDA in observation group were lower than those in control group (

0.05)

while the levels of MOT

GAS and SOD in the observation group were higher than those in control group (

0.05). The recurrence rates of observation group and control group were 3.17%(2/63) and 14.29%(9/63)

respectively

with statistically significant difference between two groups (

=5.140

0.05).

Conclusion:

The treatment of gallstones patients with chronic cholecystitis by Chaishao Shugan Lidan Paishitang has a good curative effect

and can alleviate clinical symptoms

inhibit oxidative stress and inflammation

improve liver and bile functions and gastrointestinal function

and reduce the recurrence rate.

关键词

Keywords

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