Advances in Pharmacological Mechanism of Linggui Zhugan Tang

Jun-mei CHEN; Chun-xiang ZHOU

doi:10.13422/j.cnki.syfjx.20191438

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Advances in Pharmacological Mechanism of Linggui Zhugan Tang

Review | 更新时间：2021-02-09

- Advances in Pharmacological Mechanism of Linggui Zhugan Tang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 14, Pages: 222-227(2019)
- 作者机构：
  
  南京中医药大学，南京　 210000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191438
  CLC： G353.11; R285; R318.14; R256.3; R392.3
- Received：19 January 2019，
  
  Published Online：04 April 2019，
  
  Published：20 July 2019
- 稿件说明：
移动端阅览
Jun-mei CHEN, Chun-xiang ZHOU. Advances in Pharmacological Mechanism of Linggui Zhugan Tang[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(14): 222-227.
DOI：

Jun-mei CHEN, Chun-xiang ZHOU. Advances in Pharmacological Mechanism of Linggui Zhugan Tang[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(14): 222-227. DOI： 10.13422/j.cnki.syfjx.20191438.

摘要

苓桂术甘汤临床广泛应用于由脾虚饮停引起的各种疾病，是温脾化饮法的代表方。古代医家对其组方论述也多不离脾虚饮停。现代研究发现，苓桂术甘汤组成成分大多含有抗炎、抗肿瘤以及调节免疫的作用。目前关于苓桂术甘汤的药理机制研究主要涵盖

淀粉样蛋白(A

)清除与抗神经炎症、调控脂质代谢和胰岛素抵抗、保护心肌细胞以及调节水液代谢。苓桂术甘汤可以通过调节A

关键转运蛋白的表达，包括低密度脂蛋白受体相关蛋白-1和晚期糖基化终末产物受体，促进A

清除，并且可以通过抑制小胶质细胞分泌白细胞介素(IL)-1

，IL-6和肿瘤坏死因子-

(TNF-

)等促炎因子减轻神经细胞炎症。该方还可通过调控脂联素、胰岛素和瘦素水平影响脂质代谢和胰岛素抵抗，进而对代谢综合征和非酒精性脂肪性肝病产生治疗作用。苓桂术甘汤对心肌细胞的保护机制主要涉及抑制核转录因子-

B(NF-

B)信号通路过度激活、上调Smad7蛋白表达和下调Smad3蛋白表达、调节NF-

B抑制蛋白激酶(IKK)/NF-

B抑制蛋白(I

B)/NF-

B信号通路，抑制炎症因子产生以及下调半胱氨酸蛋白酶(Caspase)-3和Caspase-8表达。此外，苓桂术甘汤还可调控水通道蛋白以影响机体水液代谢。该方还具有显著的抗氧化作用。中药复方与中医疾病证候的网络调节密切相关，借助以“疾病-靶点-药物”为特征的网络药理学完善“病-证-方”研究，有助于阐释脾虚饮停证的科学内涵以及温脾化饮法的生物学机制。

Abstract

Linggui Zhugan Tang(LGZG)

a representative of warming spleen to resolve fluid retention

is widely used in various diseases caused by spleen deficiency and fluid retention (SDFR). Ancient doctors mostly focused on the theme of SDFR to analysis the composition of LGZG. Modern research has now found that most of the components of LGZG contain anti-inflammatory

anti-tumor and immune-modulating effects. At present

the pharmacological research of LGZG mainly involves clearance of

-amyloid (A

) and anti-neuroinflammation

regulation of lipid metabolism and insulin resistance

protection of myocardial cells and regulation of liquid metabolism as follow. LGZG can promote the clearance of A

by regulating the expression of A

transporters

including low-density lipoprotein receptor-associated protein-1 and terminal glycosylation product receptors

as well as reduce the inflammation of nerve cells by inhibiting the secretion of pro-inflammatory factors such as interleukin(IL)-1

IL-6 and tumor necrosis factor-

(TNF-

) by microglia. The prescription can also affect the lipid metabolism and insulin resistance by regulating the levels of adiponectin

insulin and leptin

thus producing therapeutic effects on metabolic syndrome and non-alcoholic fatty liver disease. The protective mechanism of LGZG on myocardial cells mainly contains inhibition of the over-activation of nuclear transcription factor-

B(NF-

B) signaling pathway

up-regulation of Smad7 expression and down-regulation of Smad3 expression

regulation of inhibitor of nuclear factor kappa-B kinase (IKK) /NF-

B inhibitor (I

B) /NF-

B signaling pathway

inhibition of inflammatory factor production

and down-regulation of Caspase-3 and Caspase-8 expression. In addition

LGZG can also regulate aquaporins to affect water metabolism. And it also has significant antioxidant effects. As is known to all

the functional mechanism of traditional Chinese medicine (TCM) compound is closely related to the network regulation of TCM disease syndromes. Considered from this angle

it is helpful to carry out the " disease-syndrome-formula" research by means of network pharmacology characterized by " disease-target-drug"

thus organically exploring the relationship between LGZG and SDFR from the microscopic perspective

and helping to explain the scientific connotation of SDFR and the biological mechanism of warming spleen to resolve fluid retention.

关键词

Keywords

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