Discussion on Research and Development of Following Original Methods of Famous Classical Formulas——Taking Xiebaisan as an Example

Wang WEN; Li LI; De-kun LI; Da-zheng ZHOU; Bo-yang YU; Ai-chun JU

doi:10.13422/j.cnki.syfjx.20191446

您当前的位置：

首页 >

文章列表页 >

Discussion on Research and Development of Following Original Methods of Famous Classical Formulas——Taking Xiebaisan as an Example

Academic Discussion | 更新时间：2021-02-09

- Discussion on Research and Development of Following Original Methods of Famous Classical Formulas——Taking Xiebaisan as an Example
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 23, Pages: 196-201(2019)
- 作者机构：
  
  1.中国药科大学　中药学院，南京　 211198；
  2.天津天士力之骄药业有限公司，天津市中药注射剂新技术企业重点实验室，天津　 300410
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191446
  CLC： R22; R28; R94; R931
- Received：23 January 2019，
  
  Published Online：21 March 2019，
  
  Published：05 December 2019
- 稿件说明：
移动端阅览
Wang WEN, Li LI, De-kun LI, et al. Discussion on Research and Development of Following Original Methods of Famous Classical Formulas——Taking Xiebaisan as an Example[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(23): 196-201.
DOI：

Wang WEN, Li LI, De-kun LI, et al. Discussion on Research and Development of Following Original Methods of Famous Classical Formulas——Taking Xiebaisan as an Example[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(23): 196-201. DOI： 10.13422/j.cnki.syfjx.20191446.

摘要

国家药品监督管理局拟对符合要求的古代经典名方中药复方制剂简化注册审批流程，制备方法及给药途径与古代医籍记载一致是获得政策优惠的一大前提。由于经典名方多为清代及清代以前医籍所记载的方剂，在历代沿用过程中，药材炮制、药味用量、煎煮方式等可能发生了变化。若研究人员只是简单的采用现代方法对经典名方进行研究，容易偏离政策要求。加强前期资料调研，明确处方组成及所属朝代的用药情况能够给予经典名方研究提供强大的理论支持。基于此，笔者以《古代经典名方目录(第一批)》收载的泻白散为例，通过遵循古法原则，从药材基原、药材炮制、标准煎液的制备、泻白散颗粒剂的质量标准等方面阐述经典名方复方制剂的研发思路，为经典名方的开发与研制提供一个可借鉴的方法。

Abstract

The National Medical Products Administration intends to simplify the registration and approval process of the classic Chinese herbal compound preparations that meet the requirements

but it is a prerequisite for obtaining preferential policies that the preparation method and the route of administration are consistent with the records of ancient medical books. As most of the famous classical formulas are recorded in the medical books of the Qing dynasty and before the Qing dynasty

during the use of medicinal materials in various dynasties

the processing of herbs

dose of medicinal herbs

and the method of decocting may have changed. If researchers simply adopt modern methods to study the formula

it is easy to deviate from policy requirements. The strengthening of preliminary data survey and definition of prescription component and the medication situation of the dynasties can provide strong theoretical support for the study of famous classical formulas. Based on this

the authors take Xiebaisan as an example

which being collected in the

First Batch of Catalogue of Ancient Classical Formulas

. By following the principles of ancient methods

the research and development ideas of the classic Chinese herbal compound preparations were expounded from the aspects of origin of medicinal materials

processing of medicinal materials

preparation of standard decoction and quality standard of Xiebaisan granules

so as to provide a referential method for the development and research of the famous classical formulas.

关键词

Keywords

references

国家药品监督管理局．总局办公厅公开征求《中药经典名方复方制剂简化注册审批管理规定(征求意见稿)》及申报资料要求(征求意见稿)意见 [EB/OL]． http://www.nmpa.gov.cn/WS04/CL2101/228880.html ， 2017-09-22 / 2017-12-21 ．

国家中医药管理局．关于发布《古代经典名方目录(第一批)》的通知 [EB/OL]． http://kjs.satcm.gov.cn/zhengcewenjian/2018-04-16/7107.html ， 2018-04-13 / 2018-09-18 ．

钱乙．小儿药证直诀类证译注 [M]．孙华士，译注．太原：山西科学技术出版社， 1986 ： 96 ．

元·佚名．明目至宝 [M]．魏淳，张智军，点校．北京：人民卫生出版社， 1992 ： 230 ．

清·吴谦．御纂医宗金鉴·删补名医方论 [M]．北京：人民卫生出版社， 1963 ： 356 ．

清·汪昂．本草备要 [M]．张一昕，点校．北京：人民军医出版社， 2007 ： 127 ．

清·吴瑭．温病条辨 [M]．孙志波，点校．北京：中医古籍出版社， 2010 ： 64 ．

国家药典委员会．中华人民共和国药典．一部 [M]．北京：中国医药科技出版社， 2015 ： 86-88，124，298 ．

魏智清，于洪川，杨涓．不同产地地骨皮降血糖作用的研究 [J]．四川中医， 2009 ， 27 ( 6 )： 51 - 53 ．

李贝宁，南博，刘春生，等．道地产区甘草遗传多样性的ISSR分析 [J]．中国实验方剂学杂志， 2010 ， 16 ( 12 )： 90 - 93 ．

李学斌，陈林，李国旗，等．中国甘草资源的生态分布及其繁殖技术研究 [J]．生态环境学报， 2013 ， 22 ( 4 )： 718 - 722 ．

叶定江，原思通．中药炮制学辞典 [M]．上海：上海科学技术出版社， 2005 ： 131，234-235，465，470-471 ．

王孝涛．历代中药炮制法汇典(古代部分) [M]．南昌：江西科学技术出版社， 1998 ： 44-45，181-182 ．

路甬祥，丁安伟．中国传统工艺全集·中药炮制 [M]．郑州：大象出版社， 2004 ： 67-68，196-198 ．

吴世强，种月荣，石勇强．甘草的多法炮制及历史考证 [J]．时珍国医国药， 2005 ， 16 ( 1 )： 36 ．

陈士林，黄志海，丘小惠，等．中药精准煮散饮片 [J]．世界科学技术—中医药现代化， 2016 ， 18 ( 9 )： 1430 - 1440 ．

邢丹，贺莹，郑虎占．从《太平惠民和剂局方》论中药煮散技术规范 [J]．中国临床医生杂志， 2012 ， 40 ( 11 )： 73 - 75 ．

沈志秀，温国志，穆亚妹．宋元时期主要药用衡制量值考察 [J]．光明中医， 2013 ， 28 ( 5 )： 1056 - 1057 ．

丘光明．中国历代度量衡考 [M]．北京：科学出版社， 1992 ： 462-464，520 ．

姬航宇，仝小林，冀博文，等．中国医用度量衡发展概况 [J]．医学与哲学：人文社会医学版， 2011 ， 32 ( 19 )： 75 - 76 ．

颜文强．历代中药度量衡演变考论 [J]．老子学刊， 2016 ( 1 )： 137 - 144 ．

深州市市场监督管理局． SZDB /Z 47-2011，中药饮片煎煮规范 [EB/OL]． http://amr.sz.gov.cn/xxgk/qt/ztlm/szbz/szsdfbz_szbz/201412/W020141202347-663857484.pdf ， 2011-10-26 / 2017-12-15 ．

上海中药行业协会．上海中药行业中药煎药质量管理规范(2017试行版) [EB/OL]． http://www.stcma.cn/index.php?m=content&c=index&a=show&catid=70&id=4734 ， 2018-10-18 / 2019-01-18 ．

陈士林，刘安，李琦，等．中药饮片标准汤剂研究策略 [J]．中国中药杂志， 2016 ， 41 ( 8 )： 1367 - 1375 ．

张瑞贤，芦琴，张卫，等．宋代药物非衡量计量单位的考察 [J]．中国中药杂志， 2008 ， 33 ( 21 )： 2574 - 2576 ．

李群．桑白皮化学成分、质量控制、药理及炮制研究进展 [J]．齐鲁药事， 2011 ， 30 ( 10 )： 596-599，602 ．

丁嘉华，冯毅凡，李卫民，等． UPLC-Q-TOF-MS对桑白皮总黄酮提取物的快速分析 [J]．中国实验方剂学杂志， 2017 ， 23 ( 6 )： 78 - 84 ．

杨立伟，王海南，耿莲，等．基于标准汤剂的中药整体质量控制模式探讨 [J]．中国实验方剂学杂志， 2018 ， 24 ( 8 )： 1 - 6 ．

张静娴．中药地骨皮的化学成分与质量控制方法研究 [D]．沈阳：沈阳药科大学， 2013 ．

李海华，青梅，于娟，等．甘草的研究进展 [J]．内蒙古医科大学学报， 2015 ， 37 ( 2 )： 199 - 204 ．

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Textual Research on Ancient and Modern Literature of Xiao Chengqitang

Herbal Textual Research on Zanthoxylum armatum and Zanthoxyli Radix in Famous Classical Formulas

Herbal Textual Research on Houttuyniae Herba in Famous Classical Formulas

Key Information Research on Famous Classical Formula Shegan Mahuangtang

Herbal Textual Research on Paridis Rhizoma in Famous Classical Formulas

Related Author

Qi QI

Qing ZHANG

Wen-jun HU

Ruo-nan SHEN

Xue-chun LIU

Shou-ying DU

Yang LU

Jie BAI

Related Institution

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Shenzhen Research Institute，Beijing University of Chinese Medicine

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs，National Resource Center for Chinese Materia Medica，China Academy of Chinese Medical Sciences

Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica， Guangxi University of Chinese Medicine

Guizhou University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰