Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang

Hai-ying LI; Peng HE; Qi-meng FAN; Yu-ting HE; Yan YANG; Xue PAN; Mei-feng XIAO; Fu-yuan HE

doi:10.13422/j.cnki.syfjx.20191462

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Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang

Classic Prescriptions | 更新时间：2021-02-09

- Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 15, Pages: 37-43(2019)
- 作者机构：
  
  湖南中医药大学　药学院，中药成药性与制剂制备湖南省重点实验室，中医药超分子机理与数理特征化实验室，长沙　 410208
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191462
  CLC： R22; R94; R28; C37; O657.7
- Received：24 January 2019，
  
  Published Online：04 April 2019，
  
  Published：05 August 2019
- 稿件说明：
移动端阅览
Hai-ying LI, Peng HE, Qi-meng FAN, et al. Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 37-43.
DOI：

Hai-ying LI, Peng HE, Qi-meng FAN, et al. Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 37-43. DOI： 10.13422/j.cnki.syfjx.20191462.

摘要

目的：

建立中药及经典名方HPLC指纹图谱总量统计矩、信息量及一次投料量数学模型并进行实验验证。

方法：

运用总量统计矩原理和Hardy-Weinberg平衡群体一次稳态投料量计算方法，对来自不同产地的15批桃红四物汤原药材、饮片及复方制剂总量统计矩及一次稳态投料量进行研究。

结果：

除了总量一阶矩外，各药材、饮片及复方总量零阶矩、总量二阶矩、信息熵、信息量的RSD均>10%。用单味原药材投料，除当归外(142.34 kg)，按全方累积的信息量的RSD变化计算出的一次稳态投料量最大(59.10 kg)；而按全方的比例投料，全方一次稳态投料量最大(958.57 kg)。用炮制品投料，除酒红花外(83.28 kg)，全方累积的一次稳态投料量最大(73.18 kg)；按全方投料，炮制品一次稳态处方投料量均与原药材相同。原药材或炮制品组成的复方，其一次稳态投料量经常大于单味药材的一次稳态投料量。

结论：

中药成分受遗传多态性控制，中药色谱作用特征(成分种类)相近而作用强度(成分含量)不同，总量一阶矩、信息熵稳定说明中药多成分体系总体化学结构的印迹作用趋势稳定；桃红四物汤各药材及复方一次稳态投料量均远大于处方量，可为工业化大生产提供借鉴。

Abstract

Objective:

To establish a mathematical model of total statistical moment

information amount and one-time steady-state feeding quantity of HPLC fingerprint of traditional Chinese medicines (TCMs) and their classical prescriptions

and to carry out experimental verification.

Method:

The total statistical moment principle

Hardy-Weinberg equilibrium principle and one-time steady-state feeding quantity calculation method were used to study the total statistical moment parameters and one-time steady-state feeding quantity of 15 batches of original medicinal materials

decoction pieces and compound preparations of Taohong Siwutang

these original medicinal materials were from three producing areas.

Result:

In addition to the total first-order moment

RSD of total zero-order moment

total second-order moment

information entropy and information amount of each medicinal material

decoction piece and compound were all greater than 10%. In the case of single original medicinal material

except for Angelicae Sinensis Radix (142.34 kg)

the one-time steady-state feeding quantity calculated according to the RSD change of the accumulated information amount of the whole prescription was the largest (59.10 kg)

and according to ratio of the whole prescription

one-time steady-state feeding quantity was the largest (958.57 kg). In the case of processed products

the one-time steady-state feeding quantity of the whole prescription was the largest (73.18 kg) except for Carthami Flos processed with wine (83.28 kg)

while according to the whole prescription

one-time steady-state feeding quantity of each processed products was the same as that of the original medicinal material. The one-time steady-state feeding quantity of the compound consisted of the original medicinal materials or processed products was often higher than that of the single medicinal material.

Conclusion:

The components of TCM are controlled by genetic polymorphism

the chromatographic characteristics (types of components) of Chinese medicine is similar and the intensity of action (content of components) is different. The stability of total first-order moment and information entropy indicates that the overall chemical structure of TCM multi-component system has a stable imprinting trend. The one-time steady-state feeding quantities of each medicinal material in Taohong Siwutang and this compound are far greater than the prescription amount

which can provide reference for the industrial production.

关键词

Keywords

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Related Institution

School of Pharmacy，Hunan Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine，Laboratory of Supramolecular Mechanism and Mathematic-physics Characterization for Chinese Materia Medica，Hunan University of Chinese Medicine

College of Pharmacy，Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine（TCM），Property and Pharmacodaynamic Key Laboratory of TCM of National Administration of TCM，Hunan University of Chinese Medicine

College of Pharmacy，Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Chinese Materia Medica，Laboratory of Supramolecular Mechanism and Mathematic-physics Characterization for Traditional Chinese Medicine， Hunan University of Chinese Medicine

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