Research Progress on Herbaceous, Material Basis and Mechanism of Antidiabetic of Polygonatum Species

Ai-en TAO; Fei-ya ZHAO; Ying WANG; Cong-long XIA; Min FAN; Bao-zhong DUAN

doi:10.13422/j.cnki.syfjx.20191518

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Research Progress on Herbaceous, Material Basis and Mechanism of Antidiabetic of Polygonatum Species

Topic of Research on Medicinal Materials Resources in Yunnan | 更新时间：2021-02-09

- Research Progress on Herbaceous, Material Basis and Mechanism of Antidiabetic of Polygonatum Species
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 15, Pages: 15-24(2019)
- 作者机构：
  
  大理大学　药学与化学学院，云南　大理　 671000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191518
  CLC： R289; R285; R22; R2-031
- Received：02 November 2018，
  
  Published Online：19 April 2019，
  
  Published：05 August 2019
- 稿件说明：
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Ai-en TAO, Fei-ya ZHAO, Ying WANG, et al. Research Progress on Herbaceous, Material Basis and Mechanism of Antidiabetic of Polygonatum Species[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 15-24.
DOI：

Ai-en TAO, Fei-ya ZHAO, Ying WANG, et al. Research Progress on Herbaceous, Material Basis and Mechanism of Antidiabetic of Polygonatum Species[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 15-24. DOI： 10.13422/j.cnki.syfjx.20191518.

摘要

黄精属(

Polygonatum

)隶属于百合科(Liliaceae)，多数植物为“药食同源”类中药材，多具有养阴润燥、生津止渴等功效，民间常用于治疗“口干食少、内热消渴”等证，临床广泛用于糖尿病、高血脂及肿瘤康复。随着黄精属基础研究不断深入及产业化开发的发展，其防治糖尿病的效应成分群与作用机制不断被揭示。该文通过梳理古代本草及现代文献，对黄精属植物抗糖尿病的本草学、物质基础及其作用机制的研究进行综述，结果表明黄精属在古代本草文献和现代研究中的相关证据支持其用于糖尿病的治疗，其物质基础主要为多糖、黄酮和皂苷类成分。其中，多糖类成分是其降血糖的主要化学成分，其在抗糖尿病领域具有巨大的开发潜力。虽然目前已有学者对黄精属植物抗糖尿病药效和物质基础开展了相关研究，但缺乏系统性，且药效、作用机制、代谢途径等尚不清楚。因此，进一步加强黄精属植物相关研究，特别是从中筛选出显著的活性物质，并对其物质基础、药效学和作用机制开展研究，将对抗糖尿病药物的研发和黄精属植物的开发利用具有重要的现实意义。

Abstract

Genus

Polygonatum

belonging to the Liliaceae family

is mostly medicine food homology species

which have been documented as treating " dry mouth

less food

and internal heat and thirst" in medical ancient books. In traditional Chinese medicine clinic

it was used to treat diabetes

hyperlipemia and asa rehabilitation therapy of cancer. With deepening the basic research and industrial development of this genus

the bioactive component groups and their action mechanisms of prevention and treatment of diabetes and diabetic complication continue to be revealed. By consulting ancient Chinese herbal medicine and modern literature

the research on the herbology

material basis and mechanism of the genus

Polygonatum

were reviewed. The result indicated that the plants of

Polygonatum

were used for the treatment of diabetes

based on the ancient herbal literature and modern research

the polysaccharides

flavonoids and saponins were their active ingredients. Among them

the significant chemical constituents of decreasing blood glucose were

Polygonatum

polysaccharides

and the flavonoids and saponins also have this function. Although some scholars have studied the anti-diabetic efficacy and material basis of genus of

Polygonatum

the pharmacodynamics

mechanism and metabolic pathways are not clear. Therefore

further strengthening of the related research of genus of

Polygonatum

especially use of modern scientific and technological research to clarify the material basis of its efficacy

and mechanisms

are crucial to accelerate the modernization and development of anti-diabetic drugs and utilization of genus of

Polygonatum

关键词

Keywords

references

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