Case Study on Clinical Positioning of Large Varieties of Traditional Chinese Medicine(TCM)Guided by TCM Theory——Taking Yixinshu Capsule as an Example

Shi-huan TANG; Jing-jing ZHANG; Hong-jun YANG

doi:10.13422/j.cnki.syfjx.20191542

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Case Study on Clinical Positioning of Large Varieties of Traditional Chinese Medicine(TCM)Guided by TCM Theory——Taking Yixinshu Capsule as an Example

Academic Discussion | 更新时间：2021-02-09

- Case Study on Clinical Positioning of Large Varieties of Traditional Chinese Medicine(TCM)Guided by TCM Theory——Taking Yixinshu Capsule as an Example
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 15, Pages: 197-201(2019)
- 作者机构：
  
  中国中医科学院　中药研究所，北京　 100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191542
  CLC： R2-0; R285
- Received：15 April 2019，
  
  Published Online：29 May 2019，
  
  Published：05 August 2019
- 稿件说明：
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Shi-huan TANG, Jing-jing ZHANG, Hong-jun YANG. Case Study on Clinical Positioning of Large Varieties of Traditional Chinese Medicine(TCM)Guided by TCM Theory——Taking Yixinshu Capsule as an Example[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 197-201.
DOI：

Shi-huan TANG, Jing-jing ZHANG, Hong-jun YANG. Case Study on Clinical Positioning of Large Varieties of Traditional Chinese Medicine(TCM)Guided by TCM Theory——Taking Yixinshu Capsule as an Example[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(15): 197-201. DOI： 10.13422/j.cnki.syfjx.20191542.

摘要

临床价值是决定上市中成药产品的核心要素，明确上市中成药品种的临床定位，最大限度的发挥其临床疗效和价值，对于每一个中成药品种做大做强均具有现实意义。精确的临床定位不仅需要对现有的文献和临床实践资料进行系统分析和总结，还需要详实的实验数据加以验证和考量，为其提供基础研究的科技支撑。本课题组提出“中医理论-临床实践-基础研究”三维整合技术将对其临床定位及其评价发挥重要作用。本文仅以益心舒胶囊为例探讨中医理论指导的中成药临床定位研究，在阐释冠心病(胸痹)中医病机演变的基础上，结合该品种组成药物的核心功效，认为益心舒胶囊具有补益宗气，安定神志，活血化瘀之功效，结合冠心病的病机演变，其更为合适的临床定位主要在冠心病心绞痛的反复发作，逐步呈现慢性心力衰竭之表现。在中医理论的层面进一步指出益心舒胶囊的临床再定位，并提出深入研究的关键点，为益心舒胶囊的机制研究和临床应用提供参考。在中药大品种临床定位的研究中，以方剂及其组成药物的核心功效为基础，在中医理论的指导下实现其临床定位的精准化分析，将充分发挥中医原创知识的价值，并引导中成药大品种基础研究的方向，发挥中医理论的原创指导作用；另一方面，其研究成果最终回归到中医体系，丰富和发展中医理论，必将促进理论的升华，为中医理论指导下的中成药大品种的精确临床定位提供范式。

Abstract

The clinical value is the core factor for determining the products of Chinese patent medicines on the market. It is clear that defining the clinical positioning of Chinese patent medicines and maximizing their clinical efficacy and value are of great practical significance for each Chinese patent medicine. Precise clinical positioning not only requires systematic analysis and summarization of existing literature and clinical practice data

but also requires verification and proof from detailed experimental data

thus to provide scientific support for basic research. In this research

a three-dimensional integration strategy of " traditional Chinese medicine (TCM) theory-clinical practice-basic research" was proposed to play a vital role in clinical positioning and evaluation of Chinese patent medicines. Yixinshu capsule was taken as an example to discuss clinical positioning of Chinese patent medicines under the guidance of TCM theory. Based on the interpretation of the evolution of the pathogenesis of coronary heart disease (thoracic obstruction)

combined with the core efficacy of the drug composition

the effect of Yixinshu capsule in benefiting Zongqi

calming midnd

improving blood circulation and eliminating blood stasis was identified

which was suitable for treatment for the recurrent episodes of angina pectoris

and emergency of symptoms of chronic heart failure. At the level of TCM theory

the clinical positioning of Yixinshu capsule was further defined

and the key points of in-depth research were proposed to provide reference for the mechanism research and clinical application of Yixinshu capsule. Based on the prescription and its score functions

precise analysis of clinical positioning of large varieties of TCM under the guidance of TCM theory

on the one hand will give full play to the value of TCM original knowledge and guide the basic research of Chinese patent medicines

on the other hand the research results will enrich

benefit and sublimate the TCM theory

and finally provide a critical paradigmatic for the clinical positioning of large varieties of TCM under the guidance of TCM theory.

关键词

Keywords

references

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