Molecular Mechanism of Sanjie Zhentong Capsule in Treatment of Endometriosis, Adenomyosis, Secondary Dysmenorrhea

Zhen-zhen SU; Zhi-peng KE; Xin-zhuang ZHANG; Liang CAO; Zhen-zhong WANG; Wei XIAO

doi:10.13422/j.cnki.syfjx.20191604

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Molecular Mechanism of Sanjie Zhentong Capsule in Treatment of Endometriosis, Adenomyosis, Secondary Dysmenorrhea

Data Mining | 更新时间：2021-02-09

- Molecular Mechanism of Sanjie Zhentong Capsule in Treatment of Endometriosis, Adenomyosis, Secondary Dysmenorrhea
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 17, Pages: 165-172(2019)
- 作者机构：
  
  江苏康缘药业股份有限公司，中药制药过程新技术国家重点实验室，江苏　连云港　 222000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191604
  CLC： R2-0; R22; R285.5; R289
- Received：07 January 2019，
  
  Published Online：07 May 2019，
  
  Published：05 September 2019
- 稿件说明：
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Zhen-zhen SU, Zhi-peng KE, Xin-zhuang ZHANG, et al. Molecular Mechanism of Sanjie Zhentong Capsule in Treatment of Endometriosis, Adenomyosis, Secondary Dysmenorrhea[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 165-172.
DOI：

Zhen-zhen SU, Zhi-peng KE, Xin-zhuang ZHANG, et al. Molecular Mechanism of Sanjie Zhentong Capsule in Treatment of Endometriosis, Adenomyosis, Secondary Dysmenorrhea[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 165-172. DOI： 10.13422/j.cnki.syfjx.20191604.

摘要

目的：

分析散结镇痛胶囊治疗子宫内膜异位症、子宫腺肌症及继发性痛经的活性成分群和分子作用机制。

方法：

将散结镇痛胶囊的入血成分与子宫内膜异位症、子宫腺肌症及继发性痛经相关的靶点进行分子对接，选取对接得分较高的分子与靶蛋白构建药物-靶点网络图，分析网络特征。

结果：

网络分析结果表明散结镇痛胶囊中的6个成分可与子宫内膜异位症、子宫腺肌症及继发性痛经的87个靶点有较强的相互作用，进一步的分析阐明了散结镇痛胶囊的5个主要活性成分及23个潜在作用靶点。

结论：

散结镇痛胶囊的主要活性成分通过作用于炎症反应、细胞侵袭、凝血系统、平滑肌收缩、神经激素调节等靶点，来抑制子宫内膜的血管形成和血液循环、子宫平滑肌收缩、免疫炎症反应以及雌激素分泌，达到治疗子宫内膜异位症、子宫腺肌症及继发性痛经等病证的目的。

Abstract

Objective:

To analyze the pharmacological basis and molecular mechanism of Sanjie Zhentong capsule in the treatment of endometriosis

adenomyosis

secondary dysmenorrhea.

Method:

The 6 compounds of Sanjie Zhentong capsule showed stronger interactions with 87 proteins relating to endometriosis

adenomyosis

and secondary dysmenorrhea in molecular docking. Then the drug-target network was selected

and the network features were analyzed.

Result:

The molecular docking and network characteristics revealed 5 main active molecules and 23 potential targets of Sanjie Zhentong capsule.

Conclusion:

The main active ingredients of Sanjie Zhentong capsule have a trong inhibition effect on endometrial angiogenesis and blood circulation

uterine smooth muscle contraction

immune inflammatory reaction and estrogen secretion by acting on the targets of inflammation

cell invasion

metastasis

coagulation system

smooth muscle contraction and neurohormone regulation

so as to treat endometriosis

adenomyosis and secondary dysmenorrhea.

关键词

Keywords

references

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