Clinical Efficacy by Kidney Tonifying and Essence Strengthening Method in Regulating Pulse Wave Velocity to Delay Physiological Vascular Aging

Zheng-yu LU; Yun GU; Shui-miao LIN; Zhao-yun XIA; Lu-qian PAN

doi:10.13422/j.cnki.syfjx.20191723

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Clinical Efficacy by Kidney Tonifying and Essence Strengthening Method in Regulating Pulse Wave Velocity to Delay Physiological Vascular Aging

Clinic | 更新时间：2021-02-09

- Clinical Efficacy by Kidney Tonifying and Essence Strengthening Method in Regulating Pulse Wave Velocity to Delay Physiological Vascular Aging
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 23, Pages: 93-97(2019)
- 作者机构：
  
  1.上海中医药大学　附属岳阳中西医结合医院，上海　 200437；
  2.上海中医药大学　附属龙华医院，上海　 200032；
  3.上海市中医老年医学研究所，上海　 200031
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191723
  CLC： R22; R242; R2-031; R287
- Received：15 March 2019，
  
  Published Online：16 May 2019，
  
  Published：05 December 2019
- 稿件说明：
移动端阅览
Zheng-yu LU, Yun GU, Shui-miao LIN, et al. Clinical Efficacy by Kidney Tonifying and Essence Strengthening Method in Regulating Pulse Wave Velocity to Delay Physiological Vascular Aging[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(23): 93-97.
DOI：

Zheng-yu LU, Yun GU, Shui-miao LIN, et al. Clinical Efficacy by Kidney Tonifying and Essence Strengthening Method in Regulating Pulse Wave Velocity to Delay Physiological Vascular Aging[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(23): 93-97. DOI： 10.13422/j.cnki.syfjx.20191723.

摘要

目的：

观察补益肾精法延缓生理性血管老化的临床作用，探讨其作用机制。

方法：

采用配对研究的方法将完成该研究的62例受试者随机分为观察组和对照组，各31例，观察组口服补益肾精方药，疗程为24周，对照组不予补益肾精方药干预。该研究对受试者治疗前后的肾精亏虚证中医证候积分、脉搏波速度、颈动脉内中膜厚度、血浆同型半胱氨酸及血清超氧化物歧化酶等疗效指标进行检测，并且比较受试者治疗前后上述反映血管老化的疗效指标的变化情况。

结果：

观察组受试后肾精亏虚证中医证候积分、脉搏波速度、血浆同型半胱氨酸较本组治疗前下降，血清超氧化物歧化酶较本组治疗前升高(

0.01)；对照组肾精亏虚证中医证候积分、脉搏波速度、颈动脉内中膜厚度、血浆同型半胱氨酸较本组治疗前升高，血清超氧化物歧化酶较治疗前降低(

0.05，

0.01)。治疗后两组比较发现，观察组肾精亏虚证中医证候积分显著低于对照组(

0.01)，血清超氧化物歧化酶显著高于对照组(

0.01)。

结论：

采用补益肾精法治疗对增龄导致的生理性血管老化具有一定的延缓作用。

Abstract

Objective:

To observe the clinical efficacy of kidney tonifying and essence strengthening method in delaying physiological vascular aging.

Method:

Sixty-two subjects who completed the study were randomly divided into experimental group (31 cases) and control group (31 cases) with the matching research method. The experimental group was treated with kidney tonifying and essence strengthening recipe orally for 24 weeks

while the control group was not interfered with traditional Chinese medicine (TCM). Score of TCM syndrome in kidney deficiency syndrome

pulse wave velocity

intima-media thickness

plasma homocysteine level and serum superoxide dismutase level were evaluated before and after treatment.

Result:

Compared with before treatment period

the score of TCM syndrome in kidney deficiency syndrome

pulse wave velocity and plasma homocystenine level decreased

while the serum superoxide dismutase level increased in the experimental group after treatment (

0.01). The score of TCM syndrome in kidney deficiency syndrome

pulse wave velocity

intima-media thickness and plasma homocysteine level increased

while the serum superoxide dismutase level decreased in control group after treatment (

0.05

0.01). After treatment

the score of TCM syndrome in kidney deficiency syndrome in experimental group was lower than that in control group (

0.01)

and the serum superoxide dismutase level in experimental group was higher than that in control group (

0.01).

Conclusion:

The kidney tonifying and essence strengthening method may delay the aging of physiological blood vessels caused by aging.

关键词

Keywords

references

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