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Research Progress on Amelioration of Hemorrhagic Stroke by Traditional Chinese Medicine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 17, Pages: 226-234(2019)
- 作者机构：
中国药科大学 中药学院 江苏省中药评价与转化重点实验室，南京 211198
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20191740
CLC： R2-0; R285; R722.15+ 1; R322.81Received：09 April 2019，
Published Online：17 May 2019，
Published：05 September 2019
- 稿件说明：
移动端阅览
Mei-juan WANG, Xue-wei PAN, Yuan-yuan ZHANG, et al. Research Progress on Amelioration of Hemorrhagic Stroke by Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 226-234.
Mei-juan WANG, Xue-wei PAN, Yuan-yuan ZHANG, et al. Research Progress on Amelioration of Hemorrhagic Stroke by Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 226-234. DOI： 10.13422/j.cnki.syfjx.20191740.
摘要
脑出血，也称出血性卒中，是指非外伤性脑实质内出血，是中老年人的常见病、多发病，具有病死率高、致残率高等特点，绝大多数存活者遗留严重的神经功能缺损症状，严重威胁人类健康和生活质量。出血性脑卒中的病理过程比较复杂，主要包括血肿的形成及扩大、颅内压升高、血脑屏障的破坏、脑水肿、神经细胞凋亡以及神经功能障碍。目前西医治疗脑出血的主要方法有抗血小板治疗、降压以及祛除血肿的外科手术等，然而通常伴有手术造成的再出血、感染、神经损伤、有效灌注压不足等风险。中医认为，瘀血阻滞、内生热毒是急性期脑出血的最基本病机。研究证实许多中药可以改善脑出血相关的血脑屏障损伤、脑水肿、神经细胞凋亡以及神经功能障碍，从而减轻脑出血损伤，其调控的主要信号转导通路包括水通道转运蛋白4(AQP4)相关分子通路，磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)分子通路，核转录因子-
κ
B(NF-
κ
B)，肿瘤阻抑蛋白/B-细胞白血病淋巴瘤-2-相关X蛋白/半胱氨酸蛋白酶-3(P53/Bax/Caspase-3)分子通路等。本文从目前中药对脑出血介导脑损伤的改善作用以及干预的分子通路出发，综述近十年来发表在国外期刊的相关研究进展，以期为中医药防治出血性脑卒中的临床应用和进一步新药研发提供线索和参考依据。
Abstract
Cerebral hemorrhage
also known as hemorrhagic stroke
refers to non-traumatic intracerebral hemorrhage. Cerebral hemorrhage is a common and frequently-occurring disease in middle-aged and elderly people. It has the characteristics of high mortality and high disability rate. Most survivors have serious neurological deficits
which seriously threaten human health and quality of life.The pathological process of cerebral hemorrhage is more complicated
including the formation and expansion of hematoma
elevated intracranial pressure
destruction of blood-brain barrier
brain edema
neuronal apoptosis and neurological dysfunction.At present
the main methods for treating cerebral hemorrhage by western medicine include antiplatelet therapy
blood pressure reduction and hematoma surgery. However
it is usually accompanied by the risk of rebleeding caused by surgery
infection
nerve damage and insufficient effective perfusion pressure. Chinese medicine believes that blood stasis and endogenous fever are the most basic pathogenesis of acute cerebral hemorrhage. The previous studies found that many traditional Chinese medicine(TCM) can improve blood-brain barrier damage
brain edema
neuronal apoptosis and neurological dysfunction related to cerebral hemorrhage to reduce cerebral hemorrhage injury. Main signal transduction pathways regulated by TCM to treat cerebral hemorrhageinclude Aquaporin 4(AQP4)-related
phosphatidylinositol-3-kinase/protein kinase B(PI3K/Akt)
nuclear factor kappa B(NF-
κ
B)
suppressor protein 53/Bcl-2-associated X protein/Caspase-3(p53/Bax/Caspase-3)molecular pathways
etc.In this paper
based on the current Chinese medicine to improve the brain damage caused by cerebral hemorrhage and the molecular pathway of intervention
it reviews the research progress published in foreign journals in the past ten years
in order to provide clues and reference for the treatment of hemorrhagic stroke diseases and and the further development of new drugs.
关键词
Keywords
references
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