Research Progress of Buyang Huanwu Tang and Its Components in Treatment of Alzheimer's Disease

Yang HUANG; Ying-xin SUN; Miao ZENG; Pei-feng HUANG; Jia-li GAN; Lin YANG; Xi-juan JIANG

doi:10.13422/j.cnki.syfjx.20191805

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Research Progress of Buyang Huanwu Tang and Its Components in Treatment of Alzheimer's Disease

Review | 更新时间：2021-02-09

- Research Progress of Buyang Huanwu Tang and Its Components in Treatment of Alzheimer's Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 19, Pages: 212-218(2019)
- 作者机构：
  
  天津中医药大学，天津　 301617
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191805
  CLC： R2-0; R22; R285.5; R284.1
- Received：01 March 2019，
  
  Published Online：05 June 2019，
  
  Published：05 October 2019
- 稿件说明：
移动端阅览
Yang HUANG, Ying-xin SUN, Miao ZENG, et al. Research Progress of Buyang Huanwu Tang and Its Components in Treatment of Alzheimer's Disease[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(19): 212-218.
DOI：

Yang HUANG, Ying-xin SUN, Miao ZENG, et al. Research Progress of Buyang Huanwu Tang and Its Components in Treatment of Alzheimer's Disease[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(19): 212-218. DOI： 10.13422/j.cnki.syfjx.20191805.

摘要

阿尔茨海默病(AD)是一种起病隐匿的神经系统退行性疾病，其病因病机复杂，主要以胆碱能神经元损伤及神经突触缺失为病理改变，长期以来单一致病因素作为治疗靶点的研究收效欠佳。中医复方因其具有多通路多靶点干预的优势，在防治AD方面有显著效果。益气活血代表方-补阳还五汤广泛应用于脑血管疾病，对保护神经元、修复血脑屏障降低通透性对抗脑水肿、抵御血管内皮细胞损伤、促进新血管生成和成熟等方面具有显著的疗效。因其对大脑多方面强大的治疗作用，大量学者研究发现补阳还五汤对改善认知功能损伤疗效显著，且不同的组分通过不同的机制发挥改善认知损伤的治疗效果。但不同研究所侧重的作用机制相对单一，不利于全面认知其作用机制和干预靶点。文章总结近年相关文献从补阳还五汤及其组分降低

淀粉样前体蛋白(APP)表达减少

样淀粉蛋白沉积、抑制中枢神经系统炎症信号通路减少炎症因子释放、抑制神经元凋亡因子表达保护神经元、修复血脑屏障减少有害物质进入中枢神经系统、提高低密度脂蛋白相关受体(LRP)-1含量，降低晚期糖基化受体(RAGE)表达增加

淀粉样蛋白外周清除等方面阐述其保护神经元、改善学习及认知功能障碍的机制，以期为补阳还五汤治疗阿尔茨海默病提供有力的文献支持。

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and complex etiology and pathogenesis. The main pathological changes are the damage of cholinergic neurons and the loss of synapses. Because of advantages of multi-pathway and multi-target intervention

traditional Chinese medicine(TCM) compound prescriptions have a significant effect in the prevention and treatment of AD. Buyang Huanwu Tang

which is the representative prescription for benefiting Qi and activating blood circulation

has been widely used in cerebrovascular diseases

with significant effects in protecting neurons

repairing blood-brain barrier

reducing permeability

resisting cerebral edema and vascular endothelial cell injury and promoting new angiogenesis and maturation. Due to its powerful therapeutic effect the brain

a large number of scholars have found that Buyang Huanwu Tang has a significant effect in improving cognitive impairment

and different components can improve the therapeutic effect of cognitive impairment through different mechanisms. However

different studies focus on a relatively single mechanism of action

which is not conducive to a comprehensive understanding of its mechanisms of action and intervention targets. This article summarizes relevant literatures in recent years for the effect of Buyang Huanwu Tang and its component in reducing beta amyloid precursor protein (APP) expression and beta amyloid protein deposition

inhibiting the central nervous system inflammatory signaling pathways in reducing inflammatory cytokines release factor expression protect neurons

repair

neuron apoptosis blood brain barrier

preventing harmful substances from the central nervous system

improving the low-density lipoprotein receptor (LRP)-1 content

lowering ages receptor (RAGE) beta amyloid protein expression

and increasing peripheral clearance of

amyloid protein

and elaborated the mechanisms in protecting neurons and alleviating learning and cognitive dysfunction

in order to provide strong literature support for the treatment of Alzheimer's disease with Buyang Huanwu Tang.

关键词

Keywords

references

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