Chemical Constituents of Water Extract from <italic style="font-style: italic">Camptosorus sibiricus</italic>

Meng-ying JI; Yi-wen TAO; Xiao-xu QIAO; Hui GAO; Huan-chang DU; Peng WU; Yu-qing WANG

doi:10.13422/j.cnki.syfjx.20191920

您当前的位置：

首页 >

文章列表页 >

Chemical Constituents of Water Extract from Camptosorus sibiricus

Resource and Quality Evaluation | 更新时间：2021-04-16

- Chemical Constituents of Water Extract from Camptosorus sibiricus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 2, Pages: 124-128(2020)
- 作者机构：
  
  1.广州医科大学，广州　 511436
  2.广州中医药大学，广州　 510006
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191920
  CLC： R289; R284.2; R22; R2-031
- Received：02 April 2019，
  
  Published Online：17 June 2019，
  
  Published：20 January 2020
- 稿件说明：
移动端阅览
Meng-ying JI, Yi-wen TAO, Xiao-xu QIAO, et al. Chemical Constituents of Water Extract from Camptosorus sibiricus[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(2): 124-128.
DOI：

Meng-ying JI, Yi-wen TAO, Xiao-xu QIAO, et al. Chemical Constituents of Water Extract from Camptosorus sibiricus[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(2): 124-128. DOI： 10.13422/j.cnki.syfjx.20191920.

摘要

目的：

过山蕨为铁角蕨科过山蕨属植物过山蕨(

Camptosorus sibiricus

)的地上全草部位，是一种民间常用药，目前关于过山蕨的生物活性研究主要集中在过山蕨总黄酮上，对其化学成分的研究尚有不足，药效成分也不能完全确认。该实验对过山蕨的化学成分进行系统分离，从药效物质基础的角度探寻其作为过山蕨补充药物来源的可能性，为进一步的药理活性和充分开发利用过山蕨植物资源提供物质基础和科学依据。

方法：

采用硅胶柱，ODS开放柱，Sephadex LH-20柱以及反相高效液相色谱法对过山蕨水提物进行化学成分的分离。根据其理化性质和波谱数据鉴定化合物结构。

结果：

分离得到10个化合物，分别鉴定为(7

)-9-hydroxymegastigma-4，7-dien-3-on-9-

-glucoside(

)，bridelionoside F(

)，(3

，5

，6

，7

，9

)-megastigman-7-ene-3，5，6，9-tetrol 9-

-glucopyranoside(

)，(6

，7

，9

)-roseoside(

)，(3

，5

，6

，9

)-3-hydroxy-5，6-epoxy-

-ionol-9-

-glucopyranoside(

)，6，9-dihydroxy-4，7-megastigmadien-3-one(

)，elaphoside A(

)，ptelatoside-A(

)，

-butyl-

-fructofuranoside(

)，dibutylphthalate(

)。

结论：

首次从过山蕨属中分离得到化合物

～

，以上化合物的发现进一步丰富了过山蕨的化学成分组成，为综合开发和利用过山蕨植物资源提供前期的实验基础。

Abstract

Objective:

Camptosorus sibiricus

is a kind of herbal medicine and famous folk medicine. However

the bioactivities or pharmacological effects of the

sibiricus

remain to be unclear. Therefore

it is necessary to make a systematic study on chemical constituents from

sibiricus

so as to further study its potential medicinal value

and provide certain chemical basis and foundation for the comprehensive development and the search for pharmacological activity.

Method:

Various column chromatographic technologies

(silica gel

Sephadex LH-20 and ODS column chromatography) as well as HPLC were adopted to separate chemical constituents of

sibiricus

extract. The structure of the purified compounds was elucidated by nuclear magnetic resonance (NMR) and high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS).

Result:

Totally 10 compounds have been isolated from water extract of

sibiricus

. By spectroscopic methods

they were elucidated as 7-dien-3-on-9-

-glucoside (

)

bridelionoside F (

)

)-megastigm

an-7-ene-3

9-tetrol 9-

-glucopyranoside (

)

)-roseoside (

)

)-3-hydroxy-5

6-epoxy-

-ionol-9-

-glucopyranoside (

)

9-dihydroxy-4

7-megastigmadien-3-one (

)

)-3

9-dihydroxy-4

elaphoside A (

)

ptelatoside-A (

)

-butyl-

-fructofuranoside (

)

dibutylphthalate(

)based on physical and chemical properties.

Conclusion:

All compounds were obtained from

sibiricus

for the first time. The discovery of these compounds further enriched the chemical constituents of

sibiricus

and provided experimental and scientific basis for the comprehensive development and utilization of

sibiricus

关键词

Keywords

references

李宁，吴永军，李铣，等．过山蕨的化学成分研究(Ⅱ) [J]．中草药， 2008 ， 39 ( 1 )： 34 - 36 .

黄秀曼，杜钢军，孙婷，等．过山蕨总黄酮对肝损伤的保护作用 [J]．中草药， 2012 ， 43 ( 12 )： 2458 - 2463 .

梁大连，程艳玲，董世波，等．过山蕨总黄酮对大鼠血栓闭塞性脉管炎的改善作用 [J]．现代药物与临床， 2011 ， 26 ( 6 )： 481 - 484 .

刘迎辉，戚笑笑，李红，等．过山蕨总黄酮抗肺癌作用及其对赖氨酰氧化酶抑制活性 [J]．中草药， 2014 ， 45 ( 24 )： 3573 - 3578 .

梁大连，于亮，李宁，等．过山蕨水提物的化学成分 [J]．沈阳药科大学学报， 2017 ， 34 ( 7 )： 541 - 545，552 .

杨鑫宝，刘建勋，杨秀伟．过山蕨化学成分及药理活性研究进展 [J]．中国现代中药， 2012 ， 14 ( 5 )： 18 - 22 .

Y F LI ， L H HU ， F C LOU ， et al . PTP1B inhibitors from Ardisia japonica [J]． JANPR ， 2005 ， 7 ( 1 )： 13 - 18 .

E Sueyoshi ， H LIU ， K Matsunami ， et al . Bridelionosides A-F: megastigmane glucosides from Bridelia glauca ，f.balansae [J]． Phytochemistry ， 2006 ， 67 ( 22 )： 2483 - 2493 .

S J SONG ， L Z LI ， P Y GAO ， et al . Terpenoids and hexenes from the leaves of Crataegus pinnatifida [J]． Food Chem ， 2011 ， 129 ( 3 )： 933 - 939 .

M Herderich ， W Feser ， P Schreier ． Vomifoliol 9- O -beta- D -glucopyranosyl-4- O -beta- D -xylopyranosyl-6- O -beta- D -glucopyranoside: a trisaccharide glycoside from apple fruit .[J]． Phytochemistry ， 1992 ， 31 ( 2 )： 895 - 897 .

M S Kamel ， K M Mohamed ， H A Hassanean ， et al . Iridoid and megastigmane glycosides from Phlomis aurea [J]． Phytochemistry ， 2000 ， 55 ( 4 )： 353 - 357 .

刘江，徐硕，宋秋月，等．沙棘种子化学成分研究 [J]．亚太传统医药， 2012 ， 8 ( 4 )： 26 - 28 .

C Socolsky ． Bioactive new bitter-tasting p -hydroxystyrene glycoside and other constituents from the fern Elaphoglossum spathulatum [J]． Arkivoc ， 2003 ， 2003 ( 10 )： 347 .

M Ojika ， K Wakamatsu ， H Niwa ， et al . Structures of new p -hydroxystyrene glycosides，ptelatoside-a and ptelatoside-b isolated from bracken fern，var.and synthesis of ptelatoside-a [J]． Tetrahedron ， 1987 ， 43 ( 22 )： 5275 - 5280 .

袁久志．土茯苓和伸筋藤的化学成分研究 [D]．沈阳：沈阳药科大学， 2005 .

R CHANG ， C WANG ， Q ZENG ， et al . Chemical constituents of the stems of Celastrus rugosus [J]． Arch Pharm Res ， 2013 ， 36 ( 11 )： 1291 - 1301 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Establishment of Anti-inflammatory Activity Evaluation Method of Qingjin Huatantang Based on Phosphodiesterase Inhibitory Activity

Biological Evaluation for Quality Control of Water Extract of Qingjin Huatantang Based on Phagocytic and Secretory Functions of Macrophages

Isolation and Identification of Chemical Constituents from Ethanol Extract of Camptosorus sibiricus

Comparative Study on Coagulating Action of Water Extract and Alcohol Extract of Jingxuening Capsule

Comparative Study of Yinchenhao Tang Water Extract and Its Alcohol Extract and Their Effects on Rat Liver Injury Model

Related Author

Qiongling ZHANG

Lu LIU

Zhengxiao SUN

Shunli XIAO

Shilan DING

Jing XU

Fulong LIAO

Yun YOU

Related Institution

Institute of Chinese Materia Media， China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Tianjin Institute of Pharmaceutical Research

Shandong University of Traditional Chinese Medicine(TCM)

Shandong Academy of Pharmaceutical Sciences

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰

Chemical Constituents of Water Extract from Camptosorus sibiricus

DOI：10.13422/j.cnki.syfjx.20191920

摘要

Abstract

关键词

Keywords

references