Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis

Ya-li ZHANG; Lie ZHENG; Qian GUO; Yan-cheng DAI; Zhi-peng TANG

doi:10.13422/j.cnki.syfjx.20191924

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Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 4, Pages: 109-113(2020)
- 作者机构：
  
  1.上海中医药大学　附属龙华医院，上海　 200032
  2.上海中医药大学　脾胃病研究所，上海　 200032
  3.陕西省中医医院，西安　 710003
  4.上海中医药大学　附属上海市中西医结合医院，上海　 200082
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20191924
  CLC： R22; R242; R2-031;R287
- Received：22 March 2019，
  
  Published Online：18 June 2019，
  
  Published：20 February 2020
- 稿件说明：
移动端阅览
Ya-li ZHANG, Lie ZHENG, Qian GUO, et al. Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(4): 109-113.
DOI：

Ya-li ZHANG, Lie ZHENG, Qian GUO, et al. Clinical Efficacy of Jianpi Qingchang Decoction in Treating Patients with Spleen Deficiency Damp-heat Hormone-dependent Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(4): 109-113. DOI： 10.13422/j.cnki.syfjx.20191924.

摘要

目的：

观察健脾清肠方对激素依赖脾虚湿热型溃疡性结肠炎患者在激素撤退中的临床疗效再评价。

方法：

选择并收集2012年4月1日至2014年1月31日在上海中医药大学附属龙华医院门诊及住院脾虚湿热型激素依赖溃疡性结肠炎(ulcerative colitis，UC)患者60例，随机分为对照组和观察组，各30例。两组患者均采用标准激素减量方法撤减激素，对照组给予口服补脾益肠丸，6 g/次，3次/d。观察组给予口服健脾清肠方，每日1剂，水煎300 mL，2次/d。均连续治疗3月。治疗后观察两组患者疾病活动指数、黏膜愈合评价、中医证候疗效变化及炎症因子变化情况。

结果：

与本组治疗前比较，治疗后两组患者Mayo评分均显著减少(

0.01)，且观察组较对照组减少显著(

0.01)。治疗后观察组有66.67%进入缓解期，对照组有13.33%患者进入缓解期，观察组高于对照组(

0.01)。治疗后对照组愈合率为46.67%，观察组愈合率为70.0%，观察组高于对照组(

0.01)。治疗后对照组中医证候疗效有效率为80.0%，观察组有效率为96.67%，观察组高于对照组(

0.01)。与本组治疗前比较，两组患者白细胞介素-1(IL-1)水平均降低(

0.05)，白细胞介素-6(IL-6)，白细胞介素-10(IL-10)水平均升高(

0.05)，且治疗后与对照组比较，观察组改善明显优于对照组(

0.05)。

结论：

健脾清肠方能降低脾虚湿热型激素依赖溃疡性结肠炎患者疾病活动指数，促进黏膜愈合和改善中医症候疗效，值得临床推广。

Abstract

Objective:

To observe the effect of Jianpi Qingchang decoction on hormone withdrawal in patients with hormone-dependent spleen deficiency damp-heat ulcerative colitis.

Method:

The 60 patients with hormone-dependent ulcerative colitis with spleen deficiency and damp-heat were selected and collected from the outpatient department and the inpatient department of Longhua Hospital

Shanghai University of Traditional Chinese Medicine(TCM) between April 1

2012 and January 31

2014.All of patients in two groups were treated with standard hormone reduction method. The control group was given orally Bupi Yichang pills

6 g/time

3 times/day

and the experimental group was given orally Jianpi Qingchang recipe

300 mL water decoction

1 dose/d

2 times/d. All of the patients received continuous treatment for 3 months. After treatment

disease activity index

mucosal healing evaluation

curative effect changes of TCM syndromes and changes of inflammatory factors in the two groups were observed.

Result:

Compared with before treatment

the two groups of Mayo scores after treatment were significantly reduced (

0.01)

and the experimental group was reduced more significantly than the control group (

0.01). After treatment

66.67%of patients in experimental group were in remission

and 13.33%of patients in control group were in remission

with statistically significant differences between two groups (

0.01). After treatment

the healing rate of the control group was 46.67%

while that of the experimental group was 70.0%

with statistically significant differences (

0.01). After treatment

the effective rate of TCM syndromes in control group was 80.0%

while that in experimental group was 96.67%

with statistically significant differences (

0.01). Compared with control group before treatment

the levels of IL-1 in both groups were decreased (

0.05)

while the levels of IL-6 and IL-10 were increased (

0.05). Compared with control group after treatment

the changes in experimental group were significantly better than those in control group (

0.05).

Conclusion:

Jianpi Qingchang decoction can reduce the index of disease activity in patients with hormone-dependent ulcerative colitis due to spleen deficiency and dampness-heat

promote mucosal healing and improve the curative effect of TCM symptoms

and thus is worthy of clinical promotion.

关键词

Keywords

references

周磊．激素依赖型溃疡性结肠炎的治疗进展 [J]. 中国医药指南， 2017 , 15 ( 2 )： 16 - 17 .

周继旺，吴建业，陈军贤．序贯应用中药辅助治疗激素依赖性溃疡性结肠炎的临床分析 [J]. 中国现代医生， 2016 , 54 ( 31 )： 122 - 125 .

吴继雄，邓亚芳 . 短期糖皮质激素辅助5-氨基水杨酸口服加灌肠对中重度溃疡性结肠炎患者炎症因子及症状的影响 [J]. 实用临床医药杂志， 2016 , 20 ( 11 )： 181 - 182 .

曹珊，刘玉兰．溃疡性结肠炎患者激素抵抗预测因素分析 [J]．胃肠病学和肝病学杂志， 2010 ， 19 ( 11 )： 1040 - 1042 .

林海，姚国和，李强，等 . 硫唑嘌呤治疗激素依赖溃疡性结肠炎的IL-8、TNF- α 水平的临床研究 [J]. 齐齐哈尔医学院学报， 2017 , 38 ( 2 )： 178 - 179 .

刘秀艳，高文艳 . 难治性溃疡性结肠炎研究进展 [J]. 现代中西医结合杂志， 2017 , 26 ( 29 )： 3302 - 3306 .

李骥，韦明明，费贵军，等 . 环孢素A治疗糖皮质激素抵抗的重度溃疡性结肠炎疗效观察 [J]. 中华内科杂志， 2017 , 56 ( 4 )： 279 .

朱琪麟，史肖华 . 锡类散联合激素和蒙脱石散灌肠治疗活动期溃疡性结肠炎临床疗效与安全性 [J]. 中国处方药， 2017 , 15 ( 1 )： 84 - 85 .

Y C DAI , L ZHENG , Y L ZHANG , et al . Effects of Jianpi Qingchang decoction on the quality of life of patients with ulcerative colitis: a randomized controlled trial [J]. Medicine , 2017 , 96 ( 16 )： e6651 .

中华医学会消化病学分会炎症性肠病学组 . 炎症性肠病诊断与治疗的共识意见(2012年·广州) [J]. 中华内科杂志， 2012 , 51 ( 10 )： 818 - 831 .

中国中西医结合学会消化系统疾病专业委员会．溃疡性结肠炎中西医结合诊治方案(2003年重庆) [J]．中国中西医结合杂志， 2004 ， 24 ( 11 )： 1052 - 1055 .

胡品津 . 炎症性肠病诊断与治疗的共识意见(2012年·广州)解读 [J]. 胃肠病学， 2012 , 17 ( 12 )： 709 - 711 .

S Kugathasan , C Fiocchi . Progress in basic inflammatory bowel disease research [J]. Semin Pediatr Surg , 2007 , 16 ( 3 )： 146 - 153 .

中国中西医结合学会消化系统疾病专业委员会 . 溃疡性结肠炎中西医结合诊疗共识(2010·苏州) [J]. 现代消化及介入诊疗， 2011 ， 16 ( 1 )： 66 - 70 .

翁湘涛，胡月，廖柳，等 . 参苓白术散加减对比西药治疗溃疡性结肠炎的疗效和安全性Meta分析 [J]. 中国实验方剂学杂志， 2017 ， 23 ( 10 )： 205 - 210 .

赵莉，石志敏，李雪青 . 补脾胃泻阴火升阳汤联合美沙拉嗪治疗溃疡性结肠炎患者临床疗效观察 [J]. 中国实验方剂学杂志， 2017 ， 23 ( 14 )： 188 - 196 .

S Sud , A S Puri , S Sachdeva , et al . Tacrolimus as rescue therapy for steroid dependent/steroid refractory ulcerative colitis: experience from tertiary referral centre [J]. Gastroenterology , 2017 , 152 ( 5 )： S735 .

R S Dalal , A M Buchner , G R Lichtenstein . Factors associated with steroid-free clinical remission in ulcerative colitis [J]. Gastroenterology , 2017 , 152 ( 5 )： S369 .

王移飞，赵党生，王凤仪，等．芍药汤调节湿热型溃疡性结肠炎大鼠JAK2/STAT3和SOCS3的分子机制 [J]. 中国实验方剂学杂志， 2017 ， 23 ( 23 )： 97 - 102 .

M K Auth , S K Bunn , A L Protheroe , et al . Improved medical treatment and surgical surveillance of children and adolescents with ulcerative colitis in the United Kingdom [J]. Inflamm Bowel Dis , 2018 , 24 ( 7 )： 223 - 225 .

R Gary . Lichtenstein, paul rutgeerts, importance of mucosal healing in ulcerative colitis [J]． Inflamm Bowel Dis ， 2010 ， 16 ( 2 )： 338 - 346 .

L ZHENG , Y L ZHANG , Y C DAI , et al . Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor- κ B activation [J]. World J Gastroentero , 2017 , 23 ( 7 )： 1180 - 1188 .

张亚利，郭倩，郑烈，等．健脾清肠方治疗脾虚湿热型激素依赖溃疡性结肠炎患者的临床疗效 [J]. 中国实验方剂学杂志， 2019 ， 25 ( 10 )： 69 - 73 .

郑烈，张亚利，戴彦成，等．健脾清肠方治疗葡聚糖硫酸钠诱导溃疡性结肠炎小鼠的作用机制研究 [J]．中华中医药杂志， 2019 ， 34 ( 1 )： 344 - 347 .

郑烈，张亚利，戴彦成，等．健脾清肠方含药血清对HT29细胞内质网应激模型NF- κ B信号通路的影响 [J]．中华中医药杂志， 2019 ， 34 ( 3 )： 1194 - 1197 .

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