Clinical Efficacy of Modified Guizhi Jia Gegen Tang on Qi Stagnation and Blood Stasis Syndrome of Cervical Spondylotic Radiculopathy and Function of Neck and Upper Limb

Sheng LIU; Ling LIU; Xing-hua HAI; Wei FANG

doi:10.13422/j.cnki.syfjx.20192025

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Modified Guizhi Jia Gegen Tang on Qi Stagnation and Blood Stasis Syndrome of Cervical Spondylotic Radiculopathy and Function of Neck and Upper Limb

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Modified Guizhi Jia Gegen Tang on Qi Stagnation and Blood Stasis Syndrome of Cervical Spondylotic Radiculopathy and Function of Neck and Upper Limb
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 1, Pages: 92-97(2020)
- 作者机构：
  
  1.天津中医药大学　第一附属医院，天津　 300193
  2.天津市第四中心医院，天津　 300140
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192025
  CLC： R22; R242; R2-031; R287
- Received：08 March 2019，
  
  Published Online：27 June 2019，
  
  Published：05 January 2020
- 稿件说明：
移动端阅览
Sheng LIU, Ling LIU, Xing-hua HAI, et al. Clinical Efficacy of Modified Guizhi Jia Gegen Tang on Qi Stagnation and Blood Stasis Syndrome of Cervical Spondylotic Radiculopathy and Function of Neck and Upper Limb[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(1): 92-97.
DOI：

Sheng LIU, Ling LIU, Xing-hua HAI, et al. Clinical Efficacy of Modified Guizhi Jia Gegen Tang on Qi Stagnation and Blood Stasis Syndrome of Cervical Spondylotic Radiculopathy and Function of Neck and Upper Limb[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(1): 92-97. DOI： 10.13422/j.cnki.syfjx.20192025.

摘要

目的：

探讨桂枝加葛根汤加味治疗神经根型颈椎病(CSR)气滞血瘀证的临床疗效及对颈椎活动度、等长肌力及疼痛相关因子的影响。

方法：

将162例CSR气滞血瘀证患者随机分为观察组和对照组，各81例，观察组给予桂枝加葛根汤加味口服，150 mL/次，2次/d，对照组给予颈舒颗粒口服6 g/次，2次/d，两组患者均治疗8周；记录治疗前后正中神经F波传导速度，颈椎活动度，等长肌力，CSR 20分量表评分和视觉模拟评分(VAS)变化，治疗结束后统计总有效率和治愈率；酶联免疫夹心法检测治疗前后患者血清疼痛相关因子5-羟色胺(5-HT)，神经生长因子(NGF)，前列腺素E

(PGE

)含量。

结果：

观察组总有效率为98.77%，治愈率为40.74%，优于对照组的总有效率83.95%，治愈率7.41%(

0.01)；与本组治疗前比较，两组患者正中神经F波传导速度增快，颈椎活动度、等长肌力及CSR 20分量表评分增加，VAS评分减少，疼痛相关因子5-HT，NGF及PGE

含量下降(

0.01)；与对照组治疗后比较，观察组患者正中神经F波传导速度增快，颈椎活动度、等长肌力及CSR 20分量表评分增加，VAS评分减少，疼痛相关因子5-HT，NGF及PGE

含量下降(

0.01)。

结论：

桂枝加葛根汤加味治疗CSR气滞血瘀证临床疗效确切，可明显改善患者颈部、手部功能、减轻患者疼痛。

Abstract

Objective:

To investigate the clinical efficacy of modified Guizhi Jia Gegen Tang on cervical spondylotic radiculopathy (CSR) with Qi stagnation and blood stasis syndrome and its effect on cervical vertebral mobility

isometric muscle strength and pain-related factors.

Method:

Totally 162 CSR patients with Qi stagnation and blood stasis syndrome were randomly divided into observation group (81 cases) and control group (81 cases). The observation group was given modified Guizhi Jia Gegen Tang orally

150 mL/time

twice a day

while the control group was given Jingshu granule orally for 6 g/time

twice a day. Both groups were treated for 8 weeks. The changes of median nerve F wave conduction velocity

cervical vertebral mobility

isometric muscle strength

CSR 20 subscale score and visual analogue score (VAS) were recorded before and after treatment. The total effective rate and the cure rate were counted after treatment. The levels of serum pain-related factors (5-HT)

nerve growth factor (NGF) and prostaglandin E

(PGE

) were measured before and after treatment.

Result:

The total effective rate of the observation group was 98.77%

and the cure rate was 40.74%

which were better than 83.95%and 7.41%of the control group (

0.01). Compared with before treatment

the conduction velocity of median nerve F wave

cervical vertebral mobility

isometric muscle strength and CSR 20 score increased

whereas VAS score

pain related factors 5-HT

NGF and PGE

content decreased in both groups (

0.01). Compared with control group

median nerve F wave conduction velocity

cervical vertebral mobility

isometric muscle strength and CSR 20 subscale scores increased

while VAS score decreased

pain related factors 5-HT

NGF and PGE

contents decreased in the observation group (

0.01).

Conclusion:

Modified Guizhi Jia Gegen Tang is effective in treating CSR with Qi stagnation and blood stasis syndrome

and can significantly improve the neck and hand functions and relieve pain.

关键词

Keywords

references

张少群，李义凯．颈椎病研究的历史沿革 [J]．中国康复医学杂志， 2016 ， 31 ( 11 )： 1273 - 1276 .

张丽美，师彬．颈椎病中医辨证分型及中药治疗研究进展 [J]．中成药， 2013 ， 35 ( 7 )： 1522 - 1525 .

赵明新，董亚静，齐立卿，等．活血通络汤内服联合活络术治疗气虚血瘀证神经根型颈椎病99例 [J]．中国实验方剂学杂志， 2015 ， 21 ( 17 )： 181 - 185 .

万碧江，黄伟，张压西，等．透刺电针治疗神经根型颈椎病临床观察及对患者血浆TNF-α和IL-1 β 的影响 [J]．中华中医药学刊， 2013 ， 31 ( 2 )： 373 - 375 .

L Di Cesare Mannelli ， C Ghelardini ， L Micheli ， et al . Synergic stimulation of serotonin 5-HT1A receptor and α 2 -adrenoceptors for neuropathic pain relief: preclinical effects of 2-substituted imidazoline derivatives [J]． Eur J Pharmacol ， 2017 ， 810 ( 5 )： 128 - 133 .

詹剑，杨丽，易桂标，等．盐酸青藤碱对偏头痛大鼠中脑PAG区域NF- κ B、COX-2和5-HT表达的影响 [J]．中成药， 2015 ， 37 ( 10 )： 2121 - 2126 .

中华人民共和国卫生部．中药新药临床研究指导原则 [M]．北京：中国医药科技出版社， 2002 ： 346 - 349 .

国家中医药管理局．中医病证诊断疗效标准 [M]．北京：中国中医药出版社， 2017 ： 189 - 190 .

姜宏，施杞．介绍一种神经根型颈椎病的疗效评定方法 [J]．中华骨科杂志， 1998 ， 18 ( 6 )： 381 - 381 .

C Knop ， M Oeser ， L Bastian ， et al . Development and validation of the visual analogue scale(VAS) spine score [J]． Unfallchirurg ， 2001 ， 104 ( 6 )： 488 - 497 .

黄熙杰，陈明．桂枝加葛根汤治疗颈椎病的系统综述与META分析 [J]．世界中医药， 2017 ， 12 ( 2 )： 431 - 435 .

焦树德．方剂心得十讲 [M]．北京：人民卫生出版社， 1995 ： 196 - 196 .

Y L Lo ， L L CHAN ， T Leoh ， et al . Diagnostic utility of F waves in cervical radiculopathy：electrophysiological and magnetic resonance imaging correlation [J]． Clin Neurol Neurosurg ， 2008 ， 110 ( 1 )： 58 - 61 .

黎汝定．电针加穴位注射在神经根型颈椎病中的应用及对肌电图的影响 [J]．吉林中医药， 2017 ， 37 ( 2 )： 205 - 208 .

任蓉，蔡智刚，冯军．捣法配合烧山火针刺手法治疗神经根型颈椎病的电生理及临床研究 [J]．针灸临床杂志， 2013 ， 29 ( 8 )： 39 - 42 .

胡波，郭长青，韩森宁，等．电针对肩周炎兔血清和肌肉组织中5-HT和PGE 2 含量的影响 [J]．上海针灸杂志， 2013 ， 32 ( 2 )： 146 - 148 .

刘志明，黄山，常柄权，等．藏荆芥提取物对脑出血大鼠AQP-4及NGF表达的影响 [J]．中国实验方剂学杂志， 2018 ， 24 ( 9 )： 150 - 154 .

罗妮，郑卫红．神经生长因子致痛机制的研究进展 [J]．广东医学， 2014 ， 35 ( 11 )： 1784 - 1786 .

王小云，章路军，叶羽翀．神经根型颈椎病神经根性疼痛与炎性因子相关性研究 [J]．福建医药杂志， 2019 ， 41 ( 1 )： 13 - 15 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Animal Models of Cervical Spondylotic Radiculopathy Based on Characteristics of Clinical Symptoms of Chinese and Western Medicine

Modified Qianghuo Shengshitang Combined with Ozone Injection and Radiofrequency Thermocoagulation Target Puncture in Treatment of Cervical Spondylotic Radiculopathy with Wind-cold Blockage Type

Effect of Acupuncture Combined with Modified Shengyutang on Clinical Efficacy and T-lymphocyte Subsets in Patients with Cervical Spondylotic Radiculopathy of Qi-blood Deficiency

Effect of Zelen' s Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome

Clinical Efficacy of Duhuo Xuduan Tang in Treatment of Lumbar Disc Herniation

Related Author

YAN Xin

LI Xiaoyu

YANG Shengping

ZHANG Shuai

WANG Mingyuan

GAO Yun

CUI Yushi

LI Bobo

Related Institution

Eye Hospital， China Academy of Chinese Medical Sciences

Henan Province Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Henan University of Chinese Medicine

Henan Province Hospital of Traditional Chinese Medicine

The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (TCM)

Wuqing TCM Hospital Affiliated to Tianjin University of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰