Clinical Efficacy of Changyanqing Mixture on Chronic Recurrent Ulcerative Colitis with Damp-heat Ayndrome of Large Intestine

Long-ling CONG; Yong-hui LYU; Jia-yin YAO; Yu-jin WU; Yuan-quan ZHAN

doi:10.13422/j.cnki.syfjx.20192031

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Changyanqing Mixture on Chronic Recurrent Ulcerative Colitis with Damp-heat Ayndrome of Large Intestine

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Changyanqing Mixture on Chronic Recurrent Ulcerative Colitis with Damp-heat Ayndrome of Large Intestine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 4, Pages: 120-125(2020)
- 作者机构：
  
  1.广州市中医医院，广州　 510130
  2.中山大学　附属第六医院，广州　 510655
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192031
  CLC： R24:R289:R256:R442.2
- Received：16 May 2019，
  
  Published Online：28 June 2019，
  
  Published：20 February 2020
- 稿件说明：
移动端阅览
Long-ling CONG, Yong-hui LYU, Jia-yin YAO, et al. Clinical Efficacy of Changyanqing Mixture on Chronic Recurrent Ulcerative Colitis with Damp-heat Ayndrome of Large Intestine[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(4): 120-125.
DOI：

Long-ling CONG, Yong-hui LYU, Jia-yin YAO, et al. Clinical Efficacy of Changyanqing Mixture on Chronic Recurrent Ulcerative Colitis with Damp-heat Ayndrome of Large Intestine[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(4): 120-125. DOI： 10.13422/j.cnki.syfjx.20192031.

摘要

目的：

观察肠炎清合剂对慢性复发型溃疡性结肠炎(UC)大肠湿热证患者诱导缓解效果及维持治疗对复发的影响，并从神经-内分泌-免疫炎症网络方面探讨了其作用机制。

方法：

将112例符合要求的患者随机分成对照组55例和观察组57例。对照组内服美沙拉嗪肠溶片，1.0 g/次，4次/d；Mayo评分系统≥7分者，加服醋酸泼尼松片，0.75 mg·kg

-1

·d

-1

；加用双歧杆菌活菌散剂，1包/次，2次/d，餐后温水冲服。观察组在对照组治疗的基础上服用肠炎清合剂，1包/次，分早晚2次服用。两组疗程均为连续治疗6周，再每周门诊复诊1次。进入缓解期后，两组患者均给予美沙拉嗪肠溶片，0.5 g/次，3次/d，维持治疗；观察组仍内服肠炎清合剂内服，至大肠湿热证评分减少≥90%以上。记录进入6周内缓解期的人数和缓解时间；进行治疗前后结肠镜检查，并进行Geboes指数和Baron法评价；进行治疗前后大肠湿热证评分和Mayo评分；检测治疗前后外周血白细胞介素-6(IL-6)，IL-8，IL-10，IL-17，血管活性肠肽(VIP)，胃动素(MTL)和神经肽Y(NPY)；随访24周，记录复发情况。

结果：

经6周治疗后，观察组临床有效率为100%，黏膜愈合率为96.4%，均分别高于对照组的89.09%和81.82%(

0.05)，两组患者内镜应答率均为100%；经6周治疗后，观察组临床缓解率为91.23%，高于对照组的76.36%(

＝4.581，

0.05)，观察组平均缓解时间短于对照组(

0.01)；治疗后观察组结肠黏膜评分，Geboes指数、大肠湿热证评分和Mayo评分均低于对照组(

0.01)；观察组患者外周血IL-6，IL-8和IL-17水平均低于对照组(

0.01)，IL-10水平高于对照组(

0.01)；观察组患者外周血VIP，MTL水平均低对照组(

0.01)，NPY水平高于对照组(

0.01)；观察组复发率为17.54%，低于对照组的38.18%(

＝5.955，

0.05)；观察组平均复发时间长于对照组(

0.01)。

结论：

在常规西医治疗的基础上，肠炎清合剂用于慢性复发型UC大肠湿热证的治疗，可诱导病情缓解，缩短病程，并能降低复发率，推迟复发时间，并对神经-内分泌-免疫炎症网络具有调节作用，从而可改善病情。

Abstract

Objective:

To observe the clinical efficacy of Changyanqing mixture on chronic recurrent ulcerative colitis (UC) with damp-heat syndrome of large intestine and the effect on the recurrence of disease

in order to discuss the mechanism of action in terms of the neuro-endocrine-immune inflammation network.

Method:

One hundred and twelve patients were randomly divided into control group (55 cases) and observation group (57 cases) by random number table. Patients in control group got mesalazine slow release tablets

0.1 g/time

4 times/days

and those the score of Mayo≥7 were added with prednisone acetate tablets

0.75 mg·kg

-1

·d

-1

and bifidobacterium viable powder with warm water after dinner

1 pack/day

2 times/days. In addition to the therapy of control group

patients in observation group were also given Changyanqing mixture in the morning and evening

1 pack/day. A course of treatment was 6 weeks

and patients got further consultation once a week. During the remission stage

patients in both groups got mesalazine slow release tablets

0.5 g/time

3 times/days

and patients in observation group were added with Changyanqing mixture until the score of damp-heat syndrome of large intestine reduced by more than 90%. The number of patients entering the remission stage of 6 weeks and the time of remission stage were recorded. Before and after treatment

colonoscopy was detected

and Geboes index

Baron

damp-heat syndrome of large intestine and Mayo were scored. And levels of peripheral blood interleukin-6 (IL-6)

IL-8

IL-10

IL-17

vasoactive intestinal peptide (VIP)

motilin (MTL) and neuropeptide (NPY) were detected

and relapse at the 24-week follow-up was recorded.

Result:

After the 6-week treatment

the clinical efficacy in observation group was 100%

which was higher than 89.09%in control group (

0.05). And the healing rate of mucosa was 96.4%

which was higher than 81.82%in control group (

0.05). And the response rate in two groups was 100%. At the 6

month after the treatment

the clinical remission rate in observation group was 91.23%

which was higher than 76.36%in control group (

=4.581

0.05). And the average remission time was shorter than that in control group (

0.01). After treatment

scores of colonic mucosa

Geboes index

colonic mucosa and Mayo were all lower than those in control group (

0.01). And levels of IL-6

IL-8

IL-17

VIP and MTL were lower than those in control group (

0.01)

while levels of IL-10 and NPY were higher than those in control group (

0.01). The relapse rate in observation group was 17.54%

which was lower than 38.18%in control group (

=5.955

0.05). And the mean recurrence time was longer than that in control group (

0.01).

Conclusion:

In addition to the routine western medicine therapy

Changyanqing mixture can alleviate the condition of patients by shortening the course of the disease

reducing the recurrence rate

delaying the recurrence time

and regulating the nerve-endocrine-immune inflammation network.

关键词

Keywords

references

中华中医药学会脾胃病分会．溃疡性结肠炎中医诊疗专家共识意见(2017) [J]．中国中西医结合杂志， 2017 ， 32 ( 8 )： 3585 - 3589 .

中华医学会消化病学分会炎症性肠病学组．炎症性肠病诊断与治疗的共识意见(2018年·北京) [J]．中国实用内科杂志， 2018 ， 38 ( 9 )： 796 - 813 .

刘思雨，刘建平，康欣，等．中医药抗溃疡性结肠炎复发的优势探究 [J]．河北中医药学报， 2018 ， 33 ( 3 )： 59 - 61，64 .

孟晓燕，查安生．溃疡性结肠炎缓解期的中医复发机制及治疗进展 [J]．中医药临床杂志， 2016 ， 28 ( 11 )： 1517 - 1519 .

李军祥，谭祥，毛堂友．溃疡性结肠炎中西医结合治疗策略 [J]．中国中西医结合杂志， 2017 ， 37 ( 4 )： 398 - 400 .

傅永锦，张小牧，连大卫，等．肠炎清对溃疡性结肠炎模型大鼠中分泌型免疫球蛋白A和P选择素的影响 [J]．中国实验方剂学杂志， 2014 ， 20 ( 3 )： 148 - 152 .

顾鉴秋，邵梦茹，陈家艺，等．肠炎清口服液改善小鼠溃疡性结肠炎肠道黏膜通透性的作用机制 [J]．中国实验方剂学杂志， 2014 ， 20 ( 23 )： 133 - 137 .

丛龙玲，吕永慧，詹原泉．针刺联合肠炎清治疗大肠湿热证活动期溃疡性结肠炎临床价值分析 [J]．辽宁中医杂志， 2018 ， 45 ( 4 )： 811 - 815 .

康宜兵，吕永慧，吴宇金，等．肠炎清联合肠黏膜下注射骨髓干细胞移植治疗UC大鼠的研究 [J]．中医临床研究， 2016 ， 8 ( 14 )： 4 - 7 .

赵文畅，刘羽丹，沙磊．溃疡性结肠炎的免疫机制研究进展 [J]．医学综述， 2018 ， 24 ( 22 )： 4421 - 4426，4432 .

中华医学会消化病学分会炎症性肠病学组．炎症性肠病诊断与治疗的共识意见(2012年·广州) [J]．中华内科杂志， 2012 ， 51 ( 10 )： 818 - 831 .

朱林林，王巧民，陈思，等．溃疡性结肠炎频发的危险因素Logistic回归分析 [J]．临床医学研究与实践， 2019 ， 4 ( 11 )： 80 - 82 .

M HENRIKSEN , J JAHNSEN , I Lygren , et al . Ulcerative colitis and clinical course: results of a 5-year population-based follow-up study (the IBSEN study) [J]. Inflamm Bowel Dis , 2010 , 12 ( 7 )： 543 - 550 .

张娜，周璐，曹晓沧，等．初发型溃疡性结肠炎患者的长期随访—附37例病例分析 [J]．天津医科大学学报， 2012 ， 18 ( 1 )： 89 - 92 .

王利平，高文艳，林一帆，等．溃疡性结肠炎患者中西医维持治疗的对比研究及101例病例随访分析 [J]．中国中西医结合消化杂志， 2016 ， 24 ( 4 )： 257 - 261 .

金晨星，李芳．溃疡性结肠炎相关免疫分子及其临床应用的研究进展 [J]．中国免疫学杂志， 2019 ， 35 ( 4 )： 505 - 508，514 .

冯卓，韩昌鹏，李盈，等．祛湿清肠方内服联合中药灌肠治疗轻中度活动期溃疡性结肠炎大肠湿热证临床观察 [J]．中国实验方剂学杂志， 2018 ， 24 ( 5 )： 149 - 154 .

吕飞，田书芳，卢光新．溃疡性结肠炎患者中神经肽 Y 的检测意义分析 [J]．中国实验诊断学， 2017 ， 21 ( 6 )： 967 - 970 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical Effect of Changyanqing Mixture Combined with Mesalazine Enteric-coated Tablets for Maintenance Treatment of Ulcerative Colitis in Remission Period

Clinical Observation on Jiechang Qingre Pills Combined with Conventional Western Medicine Therapy in Improving Dampness-heat Syndrome of Large Intestine at Active Stage of Ulcerative Colitis

Nano Oral Colon Targeted Drug Delivery System in Treatment of Ulcerative Colitis： A Review

Comparison of Pharmacokinetics and Tissue Distribution of Free Anthraquinones and Gallic Acid in Mice with Ulcerative Colitis Before and After Processing of Rhei Radix et Rhizoma Carbonisata

Mechanisms of Zhuyuwan in Treating both Intrahepatic Cholestasis and Ulcerative Colitis Based on Homotherapy for Heteropathy

Related Author

Long-ling CONG

Jia-yin YAO

Yu-jin WU

Yong-hui LYU

Ya-juan YANG

Kai WANG

Zuo-wu XI

Zong-yue GAO

Related Institution

Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University

The Sixth Affiliated Hospital， Sun Yat Sen University

Second Clinical Medical College， Henan University of Chinese Medicine

Henan Province Hospital of TCM The Second Affiliated Hospital of Henan University of Chinese Medicine

Jiangxi University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰