Research on Medication Rules of Depression Syndrome Based on Ancient Medical Records

Wei-bin WANG; Jing-hua LI; Qi YU; Jun-wen WANG; Run-shun ZHANG; Yan HUANG; Ying-hui WANG

doi:10.13422/j.cnki.syfjx.20192048

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Research on Medication Rules of Depression Syndrome Based on Ancient Medical Records

Data Mining | 更新时间：2021-02-09

- Research on Medication Rules of Depression Syndrome Based on Ancient Medical Records
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 5, Pages: 162-167(2020)
- 作者机构：
  
  1.中国中医科学院　中医药信息研究所，北京　 100700
  2.中国中医科学院　广安门医院，北京　 100053
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192048
  CLC： R22; R24; R28; C37
- Received：27 April 2019，
  
  Published Online：02 July 2019，
  
  Published：05 March 2020
- 稿件说明：
移动端阅览
Wei-bin WANG, Jing-hua LI, Qi YU, et al. Research on Medication Rules of Depression Syndrome Based on Ancient Medical Records[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(5): 162-167.
DOI：

Wei-bin WANG, Jing-hua LI, Qi YU, et al. Research on Medication Rules of Depression Syndrome Based on Ancient Medical Records[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(5): 162-167. DOI： 10.13422/j.cnki.syfjx.20192048.

摘要

目的：

分析挖掘古代医家治疗郁证验案中的用药规律，以期为郁证的临床治疗提供参考。

方法：

检索、收集、整理《医案类聚》中的古代郁证医案，提取医案中的中药处方数据，对获取的处方中药数据进行规范化处理，并利用古今医案云平台V1.5集成的数据挖掘功能对中药数据进行频次统计、聚类分析、关联分析、复杂网络分析，得到古代医家治疗郁证的常用药物及其属性、分类，常用药对，核心方药组成。

结果：

经过筛选，共纳入医案数据364案，461诊次，中药处方数据439条，涉及古籍67本。共涉及中药607味，总用药频次4 127次。高频药物有茯苓(186次)，陈皮(115次)，甘草(113次)，人参(101次)，当归(98次)和白术(94次)等，常用中药性味以温、平、苦、辛为主，多归于脾、肺、心、肝四经。常用药对有白术-茯苓、茯苓-甘草、茯苓-当归、白术-甘草、人参-茯苓等，核心方药组成以丹栀逍遥散为基础加减。

结论：

古代医家治疗郁证用药以健脾补益气血、疏肝理气、养心安神为原则，气血兼顾、肝脾心同调。

Abstract

Objective:

To analyze and excavate the medication rules of ancient physicians in the treatment of depression syndrome

so as to provide reference for clinical treatment of depression syndrome.

Method:

The ancient medical records of depression syndrome sorted out in

Yian Leiju

were retrieved and collated

the data of traditional Chinese medicine (TCM) prescriptions in medical records were extracted

the obtained data of TCMs in prescriptions were standardized

and the data mining function of the ancient and modern medical records cloud platform V1.5 was adopted to carry out frequency statistics

cluster analysis

association analysis and complex network analysis of TCM data

the common drugs used by ancient physicians for treatment of depression syndrome

properties and classifications of commonly used medicines

pairs of commonly used medicines and core prescriptions were obtained.

Result:

After screening

a total of 364 medical cases

461 visits and 439 prescription data of TCM were included

involving 67 ancient books. A total of 607 Chinese medicines were involved

and the total frequency of medication was 4 127.High frequency medicines included Poria (186 times)

Citri Reticulatae Pericarpium (115 times)

Glycyrrhizae Radix et Rhizoma (113 times)

Ginseng Radix et Rhizoma (101 times)

Angelicae Sinensis Radix (98 times)

Atractylodis Macrocephalae Rhizoma (94 times)

etc. The main properties and flavors of commonly used Chinese medicines were warm

flat

bitter and acrid

which were mainly attributed to the four meridians of spleen

lung

heart and liver. Commonly used couplet medicines were Atractylodis Macrocephalae Rhizoma-Poria

Poria-Glycyrrhizae Radix et Rhizoma

Poria-Angelicae Sinensis Radix

Atractylodis Macrocephalae Rhizoma-Glycyrrhizae Radix et Rhizoma

Ginseng Radix et Rhizoma-Poria

etc. The core prescription was based on the addition and subtraction of Danzhi Xiaoyaosan.

Conclusion:

In the treatment of depression syndrome

ancient physicians adopt the principles of invigorating the spleen

nourishing Qi and blood

soothing the liver and regulating Qi

nourishing the heart and tranquilizing the mind

giving consideration to both Qi and blood

and harmonizing the liver

spleen and heart.

关键词

Keywords

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