Efficacy of Modified Bushen Huoxuetang on Kidney Deficiency and Blood Stasis Type Early Unexplained Recurrent Abortion and Its Effect on Intestinal Flora

Guang-li XU; Ji-hua ZHAO; Yan SUN; Yan-na WANG; Ai-wu WEI

doi:10.13422/j.cnki.syfjx.20192224

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Efficacy of Modified Bushen Huoxuetang on Kidney Deficiency and Blood Stasis Type Early Unexplained Recurrent Abortion and Its Effect on Intestinal Flora

Clinic | 更新时间：2021-02-09

- Efficacy of Modified Bushen Huoxuetang on Kidney Deficiency and Blood Stasis Type Early Unexplained Recurrent Abortion and Its Effect on Intestinal Flora
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 4, Pages: 102-108(2020)
- 作者机构：
  
  河南中医药大学　第一附属医院，郑州 450000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192224
  CLC： R22; R242; R2-031; R287
- Received：23 April 2019，
  
  Published Online：01 August 2019，
  
  Published：20 February 2020
- 稿件说明：
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Guang-li XU, Ji-hua ZHAO, Yan SUN, et al. Efficacy of Modified Bushen Huoxuetang on Kidney Deficiency and Blood Stasis Type Early Unexplained Recurrent Abortion and Its Effect on Intestinal Flora[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(4): 102-108.
DOI：

Guang-li XU, Ji-hua ZHAO, Yan SUN, et al. Efficacy of Modified Bushen Huoxuetang on Kidney Deficiency and Blood Stasis Type Early Unexplained Recurrent Abortion and Its Effect on Intestinal Flora[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(4): 102-108. DOI： 10.13422/j.cnki.syfjx.20192224.

摘要

目的：

探讨补肾活血汤加减治疗早期不明原因复发性流产肾虚血瘀证的疗效及对肠道菌群的影响。

方法：

选择2017年3月至2018年10月本院收治的90例早期不明原因复发性流产肾虚血瘀证患者为研究对象，按照随机数字表法分为对照组和观察组，每组45例，两组均给予常规西医治疗，对照组给予补肾活血胶囊，观察组给予补肾活血汤加减口服治疗。治疗后，比较两组患者的临床疗效、中医证候积分及不良反应，检测治疗前后两组患者的血清炎症因子，凝血功能指标及肠道菌群变化情况。

结果：

治疗后，观察组的总有效率高于对照组(

0.05)。观察组的腰膝酸软、小腹坠痛、头晕耳鸣和夜尿次数等中医证候积分低于对照组(

0.05)。治疗后观察组的C反应蛋白(C-reactive protein，CRP)，肿瘤坏死因子-

(tumor necrosis factor-alpha，TNF-

)，白细胞介素-6(interleukin-6，IL-6)和白细胞介素-8(interleukin-8，IL-8)水平低于对照组(

0.05)。治疗后观察组的凝血活酶时间(thromboplastin time，APTT)，凝血酶时间(thrombin time，TT)和凝血酶原时间(prothrombin time，PT)高于对照组，纤维蛋白原(fibrinogen，FIB)低于对照组(

0.05)。观察组的肠球菌、酵母菌和肠杆菌数量低于对照组，双歧杆菌和乳杆菌高于对照组(

0.05)。观察组不良反应发生率低于对照组(

0.05)。

结论：

补肾活血汤加减治疗早期不明原因复发性流产肾虚血瘀证具有较好的临床疗效，可降低中医证候积分，其机制可能与降低炎症反应，改善凝血功能及肠道菌群有关，且具有良好的安全性。

Abstract

Objective:

To explore the clinical efficacy of modified Bushen Huoxuetang on kidney deficiency and blood stasis type early unexplained recurrent abortion and its effect on intestinal flora.

Method:

Totally 90 patients with kidney deficiency and blood stasis type early unexplained recurrent abortion were selected from March 2017 to October 2018.According to the random number table

they were divided into control group and observation group

with 45 cases in each group. The control group was given Bushen Huoxue capsule

while the observation group was given modified Bushen Huoxuetang. After treatment

the clinical efficacy

traditional Chinese medicine (TCM) syndrome scores and adverse reactions of two groups were compared

and the changes of serum inflammatory factors

coagulation function and intestinal flora were detected before and after treatment.

Result:

After treatment

the total effective rate of the observation group was 91.11%

which was higher than 77.78%of the control group (

0.05). The scores of TCM syndromes in observation group were significantly lower than that in control group (

0.05). The levels of C-reactive protein (CRP)

tumor necrosis factor-alpha (TNF-

)

interleukin-6 (IL-6) and interleukin-8 (IL-8) in the observation group were significantly lower than those in control group (

0.05). The thromboplastin time (APTT)

thrombin time (TT) and prothrombin time (PT) in observation group were significantly higher than those in control group

while fibrinogen (FIB) was significantly lower than that in control group (

0.05). The numbers of enterococcus

yeast and Enterobacter in observation group were significantly lower than those of control group

while the numbers of bifidobacteria and Lactobacillus in observation group were significantly higher than those of control group (

0.05). The incidence of adverse reactions in observation group was 11.11%

which was lower than 28.89%of the control group (

0.05).

Conclusion:

Modified Bushen Huoxuetang has a good clinical efficacy in treating kidney deficiency and blood stasis type early unexplained recurrent abortion

and can reduce the TCM syndrome score. Its mechanism may be related to the reduction of inflammation

and improvement of coagulation function and intestinal flora

with a good safety.

关键词

Keywords

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