Effect of Zhongfeng Xingnao Liquid on Neurological Recovery of Patients with Ischemic Stroke at Early Recovery

De-yi YAO; Xing CHEN; Yun LU

doi:10.13422/j.cnki.syfjx.20192231

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Effect of Zhongfeng Xingnao Liquid on Neurological Recovery of Patients with Ischemic Stroke at Early Recovery

Clinic | 更新时间：2021-02-09

- Effect of Zhongfeng Xingnao Liquid on Neurological Recovery of Patients with Ischemic Stroke at Early Recovery
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 1, Pages: 104-109(2020)
- 作者机构：
  
  1.成都中医药大学，成都　 610075
  2.成都中医药大学　附属医院，成都　 610075
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192231
  CLC： R54; R543; R544; R256
- Received：27 June 2019，
  
  Published Online：06 August 2019，
  
  Published：05 January 2020
- 稿件说明：
移动端阅览
De-yi YAO, Xing CHEN, Yun LU. Effect of Zhongfeng Xingnao Liquid on Neurological Recovery of Patients with Ischemic Stroke at Early Recovery[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(1): 104-109.
DOI：

De-yi YAO, Xing CHEN, Yun LU. Effect of Zhongfeng Xingnao Liquid on Neurological Recovery of Patients with Ischemic Stroke at Early Recovery[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(1): 104-109. DOI： 10.13422/j.cnki.syfjx.20192231.

摘要

目的：

探讨中风醒脑液对缺血性脑中风恢复早期气虚血瘀证患者神经功能恢复的影响及抗炎、神经保护和改善微循环机制。

方法：

将128例患者采用随机按数字表法分为对照组和观察组各64例。两组患者基础治疗，口服阿托伐他汀钙片，10 mg·d

-1

；口服阿司匹林肠溶片，100 mg·d

-1

；控制血压、血糖，结合现代康复训练。观察组口服中风醒脑液，25 mL/次，3次/d；对照组口服中风醒脑液模拟剂，25 mL/次，3次/d。两组疗程均连续治疗90 d。记录治疗后不同时点美国国立卫生院神经功能缺损(NIHSS)评分；进行治疗前后Barthel指数，改良Rankin量表，Brunel平衡量表(BBA)，Fugl-Meyer量表(FMA)，气虚血瘀证评分和中风专用生活质量量表(SS-QOL)评分；检测治疗前后脑源性神经营养因子(BDNF)，肿瘤坏死因子-

(TNF-

)，同型半胱氨酸(Hcy)，血清胱抑素C(Cys-C)，血小板聚集率(ADP)，纤维蛋白原(FIB)水平。

结果：

观察组临床疗效优于对照组(

＝1.981，

0.05)；观察组在治疗后不同时点NIHSS评分均低于对照组(

0.01)；观察组Barthel指数，FMA，BBA，SS-QOL评分均高于对照组(

0.01)，气虚血瘀证评分低于对照组(

0.01)；观察组残疾程度轻于对照组(

＝1.932，

0.05)；观察组运动障碍程度轻于对照组(

＝2.149，

0.05)；观察组BDNF水平高于对照组(

0.01)，TNF-

，Hcy，Cys-C，ADP和FIB水平均低于对照组(

0.01)。

结论：

在常规西医综合康复措施的基础上，中风醒脑液可促进脑梗死恢复期(气虚血瘀证)患者神经功能缺损修复，有利于患者的康复，提高了生活质量，并具有一定的抗炎、改善微循环和神经保护作用，疗效优于单纯的西医综合康复治疗。

Abstract

Objective:

To discuss the effect of Zhongfeng Xingnao liquid on neurological recovery of patients of ischemic stroke with Qi deficiency and blood stasis syndrome at early recovery

and the mechanisms of anti-inflammation

neuroprotection and improvement of microcirculation.

Method:

One hundred and twenty-eight patients were randomly divided into control group (64 cases) and observation group (64 cases) by random number table. Both groups’ patients got atorvastatin

10 mg/days

aspirin enteric-coated tablets

100 mg/days

and control of blood pressure and blood sugar

and modern rehabilitation training. Patients in control group orally got Zhongfeng Xingnao liquid

25 mL/time

3 times/days. The course of treatment was 90 days. And before and after treatment

national institutes of health neurological deficiency (NIHSS)

Barthel index

improvement Rankin scale

brunel balance scale (BBA)

Fugl-Meyer scale (FMA)

Qi deficiency and blood stasis syndrome (SS-QOL) were scored. And levels of brain-derived neurotrophic factor (BDNF)

tumor necrosis factor-alpha (TNF-alpha)

homocysteine (Hcy)

serum cystatin C (Cys-C)

platelet aggregation rate (ADP) and fibrinogen (FIB) were detected.

Result:

The clinical efficacy in observation group was better than that in control group (

=1.981

0.05). At different time points after treatment

scores of NIHSS and Qi deficiency and blood stasis syndrome were lower than those in control group (

0.05)

whereas scores of Barthel index

FMA

BBA and SS-QOL were higher than those in control group (

0.01). Degrees of disability and dyskinesia in observation group was lighter than those in control group (

=1.932

0.05). Degree of dyskinesia was lighter than that in control group (

=2.149

0.05). And level of BDNF was higher than that in control group (

0.01)

while levels of TNF-

Hcy

Cys-C

ADP and FIB were lower than those in control group (

0.01).

Conclusion:

In addition to the routine comprehensive rehabilitation measures of western medicine

Zhongfeng Xingnao liquid can promote recovery of nerve function defect of patients of cerebral infarction with Qi deficiency and blood stasis syndrome at convalescence

is beneficial for rehabilitation of patients and improving the quality of life

with certain effects in resisting inflammation

improving microcirculation and protecting nerves

and better efficacy than simple western medicine treatment.

关键词

Keywords

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