Research Progress on Organic-inorganic Hybrid Nanocarriers of Active Ingredients from Chinese Materia Medica

Zi-fei JIANG; Ying LIU; Nian-ping FENG

doi:10.13422/j.cnki.syfjx.20192247

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Research Progress on Organic-inorganic Hybrid Nanocarriers of Active Ingredients from Chinese Materia Medica

Review | 更新时间：2021-02-09

- Research Progress on Organic-inorganic Hybrid Nanocarriers of Active Ingredients from Chinese Materia Medica
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 5, Pages: 202-209(2020)
- 作者机构：
  
  上海中医药大学　中药学院，上海　 201203
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192247
  CLC： R22; R94; R28; G353.11; TB3
- Received：28 April 2019，
  
  Published Online：01 August 2019，
  
  Published：05 March 2020
- 稿件说明：
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Zi-fei JIANG, Ying LIU, Nian-ping FENG. Research Progress on Organic-inorganic Hybrid Nanocarriers of Active Ingredients from Chinese Materia Medica[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(5): 202-209.
DOI：

Zi-fei JIANG, Ying LIU, Nian-ping FENG. Research Progress on Organic-inorganic Hybrid Nanocarriers of Active Ingredients from Chinese Materia Medica[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(5): 202-209. DOI： 10.13422/j.cnki.syfjx.20192247.

摘要

纳米载体在改善中药有效成分溶解性、生物膜透过性与生物体内行为、增效减毒等方面发挥着重要作用，具有广阔的应用前景。作为新型纳米载体，有机-无机杂化纳米载体由有机和无机材料或载体复合而形成，结合了两者的优势，能够更好地发挥其在药物递送中的作用，提高药物稳定性、载药量和生物相容性，并可以实现多功能化。笔者对近年来国内外中药有效成分有机-无机杂化纳米载体的研究和应用情况进行了总结与分析，并展望其发展前景，可为高效安全递送中药有效成分的新型递药系统的研究提供参考。

Abstract

Nanocarriers for delivering active ingredients from Chinese materia medica play an important role in improving their solubility

membrane permeability and

in vivo

biological behavior

enhancing the therapeutic efficiency and reducing side effects. They are promising for extensive research and application. As novel nanocarriers

organic-inorganic hybrid nanocarriers composed of organic materials or carriers and inorganic parts possess the dual advantages of organic carriers and inorganic carriers. They may exert desirable action in drug delivery. In addition

they have been designed to improve the stability and biocompatibility

further increase the therapeutic efficiency and reduce side effects. They have also been investigated to achieve multi-functionality. In this paper

the research and application of organic-inorganic hybrid nanocarriers delivering active ingredients from Chinese materia medica were summarized and analyzed. The development and application prospect of organic-inorganic hybrid nanocarriers are prospected. The aim of this review is to provide a reference for the investigation of new drug delivery system for delivering active ingredients from Chinese materia medica efficiently and safely.

关键词

Keywords

references

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