Optimization of Formulation of Fufang Huangqi Cream by D-optimal Mixture Design Based on AHP-CRITIC Analysis

Yong-jie WANG; Ming-yi SUN; Li-li DENG; Ying ZHAO; Xin LIU; Xin-yan LIU; Jia LIU; Qing WU; Yuan LI

doi:10.13422/j.cnki.syfjx.20192248

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Optimization of Formulation of Fufang Huangqi Cream by D-optimal Mixture Design Based on AHP-CRITIC Analysis

Pharmacy and Processing | 更新时间：2021-02-09

- Optimization of Formulation of Fufang Huangqi Cream by D-optimal Mixture Design Based on AHP-CRITIC Analysis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 3, Pages: 110-116(2020)
- 作者机构：
  
  1.北京中医药大学　中药学院，北京　 102488
  2.中日友好医院，北京　 100029
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192248
  CLC： R22; R94; R28; C37; O37
- Received：30 May 2019，
  
  Published Online：02 August 2019，
  
  Published：05 February 2020
- 稿件说明：
移动端阅览
Yong-jie WANG, Ming-yi SUN, Li-li DENG, et al. Optimization of Formulation of Fufang Huangqi Cream by D-optimal Mixture Design Based on AHP-CRITIC Analysis[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(3): 110-116.
DOI：

Yong-jie WANG, Ming-yi SUN, Li-li DENG, et al. Optimization of Formulation of Fufang Huangqi Cream by D-optimal Mixture Design Based on AHP-CRITIC Analysis[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(3): 110-116. DOI： 10.13422/j.cnki.syfjx.20192248.

摘要

目的：

优化复方黄芪乳膏的处方并对其流变学性质进行评价。

方法：

以复方黄芪乳膏的外观性状、涂展性和稳定性作为评价指标，采用层次分析法(AHP)，基于指标相关性的指标权重确定方法(CRITIC)，AHP-CRITIC混合加权法确定各评价指标的权重系数，结合D-最优混料设计优化复方黄芪乳膏的处方，并对其流变学性质进行评价。

结果：

按AHP-CRITIC混合加权法得到外观性状、涂展性和稳定性的权重系数分别为0.185，0.282和0.532，D-最优混料设计得到复方黄芪乳膏最优基质处方为液体石蜡3.70 g，白凡士林2.00 g，硬脂酸2.00 g，十二烷基硫酸钠5.90 g，甘油6.00 g，提取液20.40 g。复方黄芪乳膏流变学参数为非牛顿指数<1，储能模量>损耗模量。

结论：

优选的基质处方稳定可行。复方黄芪乳膏外观良好，是剪切变稀型非牛顿流体，黏度和延展性符合工业生产及临床应用的需要。

Abstract

Objective:

To optimize the matrix prescription of Fufang Huangqi cream and evaluate its rheological properties.

Method:

With appearance

spreadability and stability as evaluation indexes

the weighting coefficient of each evaluation index was determined by analytic hierarchy process (AHP)

criteria importance through intercriteria correlation method (CRITIC) and AHP-CRITIC mixed weighting method. The formulation of Fufang Huangqi cream was optimized by D-optimal mixture design and its rheological properties were evaluated.

Result:

The weight coefficients of appearance

spreadability and stability according to AHP-CRITIC mixed weighting method were 0.185

0.282 and 0.532

respectively. According to D-optimal mixture design based on AHP-CRITIC analysis

the optimized formulation of Fufang Huangqi cream was liquid paraffin of 3.70 g

vaseline of 2.00 g

stearic acid of 2.00 g

sodium dodecyl sulfate of 5.90 g

glycerin of 6.00 g and extract of 20.40 g. The rheological parameters of Fufang Huangqi cream was non-newtonian index<1

storage modulus>loss modulus.

Conclusion:

The preferred matrix formulation is stable and feasible. Fufang Huangqi cream has good appearance and is a shear thinning non-newtonian fluid. Its viscosity and ductility meet the needs of industrial production and clinical application.

关键词

Keywords

references

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