Ancient and Modern Literature on Clinical Application of Biejia Jianwan in <italic style="font-style: italic">Medical Treasures of the Golden Chamber</italic>

Si-hong LIU; Sha-sha LI; You-juan HOU; Bin LI; Yan DONG; Bing LI

doi:10.13422/j.cnki.syfjx.20192321

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Ancient and Modern Literature on Clinical Application of Biejia Jianwan in Medical Treasures of the Golden Chamber

Classic Prescriptions | 更新时间：2021-02-09

- Ancient and Modern Literature on Clinical Application of Biejia Jianwan in Medical Treasures of the Golden Chamber
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 6, Pages: 12-17(2020)
- 作者机构：
  
  中国中医科学院　中医药信息研究所，北京　 100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192321
  CLC： R22; R242; R2-031; R285.5;R287
- Received：21 March 2019，
  
  Published Online：15 August 2019，
  
  Published：20 March 2020
- 稿件说明：
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Si-hong LIU, Sha-sha LI, You-juan HOU, et al. Ancient and Modern Literature on Clinical Application of Biejia Jianwan in Medical Treasures of the Golden Chamber[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 12-17.
DOI：

Si-hong LIU, Sha-sha LI, You-juan HOU, et al. Ancient and Modern Literature on Clinical Application of Biejia Jianwan in Medical Treasures of the Golden Chamber[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 12-17. DOI： 10.13422/j.cnki.syfjx.20192321.

摘要

目的：

系统梳理《金匮要略》鳖甲煎丸的历代衍变情况、古今临床应用情况，并分析其在现代的应用转化情况，一方面为鳖甲煎丸的二次开发提供思路，另一方面为经典名方的转化和应用提供参考。

方法：

搜集与整理鳖甲煎丸的古代文献与现代文献，对鳖甲煎丸的古代及现代临床应用情况进行梳理，研究其源流、方义衍变及主治病证变化情况。结合市场调研，对鳖甲煎丸的市场转化情况进行分析，分析其研发过程及市场应用情况。

结果：

自《金匮要略》后，鳖甲煎丸在历代均有流传，但其变化不大，治疗疾病单一，为治疟母的专方。从药物剂量比来看，鳖甲煎丸中鳖甲和赤硝为主药，并重用虫类药。现代文献分析发现，鳖甲煎丸无论是临床研究还是实验研究，均主要用于治疗肝纤维化、肝硬化、肝癌等肝脏疾病。调研发现，鳖甲煎丸在由经方转化为中成药时，其思路基本为“尊古”，其组成、用量、制法等基本遵循了《金匮要略》中原方的记载。中成药制剂已被收录于多个疾病诊疗、用药指南及专家共识中。对比其他抗肝纤维化的中成药，鳖甲煎丸的临床应用较广，成本较低。

结论：

鳖甲煎丸在古代为治疗疟母的专方，现代则多用来治疗肝纤维化等肝脏疾病，疗效确切。此外，鳖甲煎丸已成功地转化为现代中成药制剂，并在市场上得到较好的反应，为其他经典名方的转化和应用提供了参考。

Abstract

Objective:

To systematically review the evolution of Biejia Jianwan in

Medical Treasures of the Golden Chamber

and its clinical application in ancient and modern times

in order to analyze its application and transformation in modern times. For one thing

it provided ideas for the secondary development of Biejia Jianwan

for another

it provided reference for the transformation and application of classical famous prescriptions.

Method:

Ancient and modern literature of Biejia Jianwan were collected and summarized to study the ancient and modern clinical application of Biejia Jianwan

and its origin

evolution of prescription meanings and changes of main indications. Based on market research

the market transformation of Biejia Jianwan

and its research and development process and market application were analyzed.

Result:

Biejia Jianwan has been applied in past dynasties since the

Medical Treasures of the Golden Chamber

but with insignificant changes and simple indications. In fact

Biejia Jianwan was specially developed for the treatment of malaria with abdominal mass. According to the drug dosage ratio

Trinycis Carapax and Chixiao are the main drugs in Biejia Jianwan

and insect drugs are also used. Modern literature analysis shows that Biejia Jianwan is mainly used to treat liver diseases

such as liver fibrosis

cirrhosis and liver cancer

whether in clinical or experimental studies. It was found that when Biejia Jianwan was transformed from a classical prescription into a Chinese patent medicine mainly based on its composition

dosage and preparation of the original prescription recorded in the

Medical Treasures of the Golden Chamber

. Chinese patent medicine preparations have been included in many diseases diagnosis and treatment

medication guidelines and expert consensus. Compared with other traditional Chinese medicines

Biejia Jianwan is more widely used in clinic with lower costs.

Conclusion:

Biejia Jianwan is used to treat malaria with abdominal mass in ancient times

but in modern times it is mostly used to treat liver diseases

such as liver fibrosis

with a definite efficacy. In addition

Biejia Jianwan have been successfully transformed into a modern Chinese patent medicine preparation

and achieved a better response in the market

providing a reference for the transformation and application of other classical prescriptions.

关键词

Keywords

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Ancient and Modern Literature on Clinical Application of Biejia Jianwan in Medical Treasures of the Golden Chamber

DOI：10.13422/j.cnki.syfjx.20192321

摘要

Abstract

关键词

Keywords

references