Clinical Efficacy and Mechanism of Longdan Xiegantang in Treatment of Pelvic Inflammatory Infertility

Jiao LI; Jie LIN

doi:10.13422/j.cnki.syfjx.20192322

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy and Mechanism of Longdan Xiegantang in Treatment of Pelvic Inflammatory Infertility

Clinic | 更新时间：2021-02-09

- Clinical Efficacy and Mechanism of Longdan Xiegantang in Treatment of Pelvic Inflammatory Infertility
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 6, Pages: 85-90(2020)
- 作者机构：
  
  湖南中医药大学　第一附属医院，长沙　 410007
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192322
  CLC： R22; R242; R2-031;R287
- Received：02 April 2019，
  
  Published Online：16 August 2019，
  
  Published：20 March 2020
- 稿件说明：
移动端阅览
Jiao LI, Jie LIN. Clinical Efficacy and Mechanism of Longdan Xiegantang in Treatment of Pelvic Inflammatory Infertility[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 85-90.
DOI：

Jiao LI, Jie LIN. Clinical Efficacy and Mechanism of Longdan Xiegantang in Treatment of Pelvic Inflammatory Infertility[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 85-90. DOI： 10.13422/j.cnki.syfjx.20192322.

摘要

目的：

观察龙胆泻肝汤治疗湿热瘀结型盆腔炎性不孕的临床疗效，并探讨其治疗的作用机制。

方法：

选择湖南中医药大学第一附属医院2017年1月至2018年12月收治的150例湿热瘀结型盆腔炎性不孕患者为研究对象，按照随机数字表法分为对照组和观察组，每组75例，对照组给予抗生素联合肝胆双清颗粒治疗，观察组给予龙胆泻肝汤联合抗生素治疗，两组均连续治疗6周。比较两组患者的临床疗效、中医证候积分、血液流变学及血清生化指标、炎症因子水平和免疫功能指标。

结果：

观察组总有效率93.33%(70/75)，高于对照组的78.67%(59/75)(

＝6.480，

0.05)。观察组妊娠率58.33%，显著高于对照组的33.82%(

＝8.862，

0.01)。治疗前两组患者的中医证候积分、血液流变学及血清生化指标、炎症因子水平和免疫功能指标差异无统计学意义。与本组治疗前比较，治疗后两组患者下腹腹痛、肛门坠胀、腰骶疼痛、带下异常和月经失调等中医证候积分降低(

0.05)；血液流变学指标血浆黏度、红细胞积压、全血黏度高切和低切水平降低(

0.05)；抑制素-A(INH-A)水平升高，孕酮(P)和

-绒毛膜促性腺激素(

-HCG)水平降低(

0.05)；血清C-反应蛋白(CRP)，白细胞介素-6(IL-6)和肿瘤坏死因子(TNF)-

水平降低(

0.05)；CD4

＋

和CD8

＋

水平升高(

0.05)；免疫球蛋白(Ig)A，IgG，IgM水平降低(

0.05)。与对照组治疗后比较，观察组下腹腹痛、肛门坠胀、腰骶疼痛、带下异常和月经失调等中医证候积分降低，血液流变学指标血浆黏度、红细胞积压、全血黏度高切和低切水平降低，INH-A水平升高，P和

-HCG水平显著降低，血清CRP，IL-6和肿瘤坏死因子(TNF-

)水平显著降低，CD4

＋

和CD8

＋

水平升高，IgA，IgG和IgM水平降低(

0.05)。两组患者在治疗期间未见明显不良反应。

结论：

龙胆泻肝汤治疗湿热瘀结型盆腔炎性不孕具有较好的临床疗效，可降低中医证候积分，提高妊娠率，其机制可能与改善血液流变学及血清生化指标，抑制炎症因子表达和增强免疫功能有关。

Abstract

Objective:

To observe the clinical efficacy of Longdan Xiegantang in the treatment of pelvic inflammatory infertility with damp-heat phlegm and phlegm

in order to explore its mechanism of action.

Method:

Totally 150 patients with phlegm and inflammatory pelvic inflammatory infertility admitted to First Hospital of Hunan University of Chinese Medicine from January 2017 to December 2018 were enrolled in the study. According to the random number

the patients were divided into control group and observation group

with 75 cases in each group. Control group was given antibiotics combined with Gandan Shuangqing granule

and observation group was given Longdan Xiegantang combined with antibiotics. Both groups were treated for 6 weeks. The clinical efficacy

traditional Chinese medicine (TCM) syndrome scores

blood rheology and serum biochemical parameters

inflammatory factor levels and immune function indexes of the two groups were compared.

Result:

The total effective rate of observation group was 93.33%

which was higher than 78.67% of control group (

=6.480

0.05). The pregnancy rate of observation group was 58.33%

which was significantly higher than 33.82% of control group (

=8.862

0.01). Before treatment

there was no significant difference in TCM syndrome score

hemorheology

serum biochemical index

inflammatory factor level and immune function between the two groups. Compared with before treatment

the TCM syndrome scores of lower abdominal pain

anal bulge

lumbosacral pain

abnormal bandage and menstrual disorders were significantly reduced

the levels of plasma viscosity

hematocrit

high and low-shear whole blood viscosity were significantly reduced

the level of inhibin-A (INH-A) was significantly increased

the level of progesterone (P) and beita chorionic gonadotropin (

-HCG) were significantly reduced

the levels of serum C-reactive protein (CRP)

interleukin-6 (IL-6) and tumor necrosis factor-

(TNF-

) were significantly decreased

the levels of CD4

and CD8

were significantly increased

and the levels of IgA

IgG and IgM were significantly decreased (

0.05). After treatment

in observation group

TCM syndrome scores of the lower abdominal pain

anal bulge

lumbosacral pain

abnormal bandage and menstrual disorders were significantly reduced

the levels of plasma viscosity

hematocrit

high and low-shear whole blood viscosity were significantly reduced

the level of INH-A was significantly increased

and the level of P and

-HCG were significantly reduced

the levels of serum CRP

IL-6

TNF-

were significantly decreased

the levels of CD4

and CD8

were significantly increased

and the levels of IgA

IgG and IgM were significantly decreased (

0.05). There was no obvious adverse reaction in two groups during the treatment.

Conclusion:

Longdan Xiegantang has a good clinical effect in treating pelvic inflammatory infertility with damp-heat phlegm and phlegm

and can reduce TCM syndrome scores

and increase pregnancy rate. The mechanism may be correlated with the improvement of blood rheology and serum biochemical indicators

the inhibition of inflammatory factors and the enhancement of immune function.

关键词

Keywords

references

W SONG , D ZHOU , W XU ， et al . Factors of pelvic infection and death in patients with open pelvic fractures and rectal injuries [J]. Surg Infect (Larchmt) ， 2017 ， 18 ( 6 ): 711 - 715 .

张艳宏，谢雁鸣，罗颂平，等．《中医药单用/联合抗生素治疗常见感染性疾病临床实践指南：盆腔炎性疾病》解读 [J]．环球中医药， 2018 ， 11 ( 10 ): 1545 - 1547 .

张新庄，萧伟，徐筱杰，等．基于网络药理学的桂枝茯苓胶囊治疗痛经、子宫肌瘤和盆腔炎的分子作用机制研究 [J]．中草药， 2016 ， 47 ( 1 ): 81 - 94 .

董巧娥，张淑艳．盆腔炎汤治疗慢性盆腔炎的疗效及机制研究 [J]．中医临床研究， 2018 ， 10 ( 18 ): 100 - 102 .

谢芳，孙孔云，刘桂荣，等．国医大师张志远治疗盆腔炎经验 [J]．湖南中医药大学学报， 2018 ， 38 ( 3 ): 242 - 244 .

谈勇，夏桂成，陈婕，等．国医大师夏桂成论治盆腔炎的特点探析 [J]．南京中医药大学学报， 2017 ， 33 ( 6 ): 545 - 546 .

周春巧，文君，陈宇．龙胆泻肝汤的药理作用及其临床应用研究进展 [J]．临床合理用药杂志， 2018 ， 11 ( 33 ): 180 - 181 .

袁蕾，王翠翠，苏凯凯．龙胆泻肝汤加减对湿热蕴结型慢性盆腔炎的疗效及对炎性反应因子的影响 [J]．世界中医药， 2018 ， 13 ( 9 ): 2155 - 2158 .

曹泽毅．中华妇产科学 [M]. 2版．北京：人民卫生出版社， 2007 ： 1212 - 1223 .

中华人民共和国卫生部 . 中药新药临床研究指导原则 [M]. 北京：中国中医药出版社， 2002 ： 246 - 253 .

M PAPIC , N WANG , S M PARISI ， et al . Same-day intrauterine device placement is rarely complicated by pelvic infection [J]. Womens Health Issues ， 2015 ， 25 ( 1 ): 22 - 27 .

高艳霞，薛惠英，刘现红．疏肝养血汤联合西药盆腔灌注治疗慢性盆腔炎疗效及对患者血流变、免疫功能的影响 [J]．陕西中医， 2018 ， 39 ( 11 ): 1576 - 1579 .

李芳园，张迎春．复方藤酱汤保留灌肠治疗慢性盆腔炎的疗效及对血流动力学、炎症因子的影响 [J]．环球中医药， 2018 ， 11 ( 8 ): 1261 - 1263 .

马堃，李敏，王凯莉，等．《中医药单用/联合抗生素治疗盆腔炎性疾病临床实践指南》临床应用评价与修订意见 [J]．中国中药杂志， 2018 ， 43 ( 24 ): 4741 - 4745 .

马堃，罗颂平，李敏，等．中医药防治盆腔炎性疾病优势与证据研究进展 [J]．中国中药杂志， 2017 ， 42 ( 8 ): 1449 - 1454 .

李俊波，邓芳，李霄汉，等．龙胆泻肝汤对PCOS模型大鼠的影响 [J]．中国实验方剂学杂志， 2018 ， 24 ( 7 ): 121 - 126 .

雷鸣，李伟宁，姚斌，等．龙胆泻肝汤加减治疗寻常型银屑病(血热型)的临床观察 [J]．中国药房， 2017 ， 28 ( 33 ): 4640 - 4643 .

张泽鑫，黄志凯，曾慕煌，等．龙胆泻肝汤方的药理研究进展 [J]．国医论坛， 2018 ， 33 ( 4 ): 67 - 70 .

罗超兰，胡正昌，杨向东．龙胆泻肝汤联合美沙拉嗪治疗湿热下注型溃疡性结肠炎的临床观察 [J]．中国中医药科技， 2018 ， 25 ( 5 ): 696 - 697 .

鲁士友，宿艳．龙胆泻肝汤加减联合针灸治疗肝火炽盛证单纯疱疹病毒性角膜炎 [J]．中国实验方剂学杂志， 2018 ， 24 ( 15 ): 216 - 221 .

刘文泓，杜红兵，杨逢生．龙胆泻肝汤加减治疗湿热下注型慢性前列腺炎的临床疗效分析 [J]．中医临床研究， 2018 ， 10 ( 24 ): 79 - 80 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacy and Mechanism of Qingre Lishi Prescription in Treating Children with Acute Bacterial Lower Urinary Tract Infection of Bladder Damp-heat Syndrome

Effect of Longdan Xiegantang on Serum Inflammatory Factors, Related Proteins and Immune Function in Patients with Secretory Otitis Media

Effect of Bufei Jianpi Yishen Decoction on Nutritional Status Immune Function of Chronic Obstructive Pulmonary Disease at Stable Period

Effect of Shenling Baishu San Combined with Antibiotics on Serum Inflammatory Factors, Immune Function in Senile Community-acquired Pneumonia with Syndrome of Qi Deficiency of Both Lung and Spleen

Protective Effect against Helicobacter pylor Gastritis in Mice by Flavonoid Combinations of Alpiniae Officinarum Rhizoma via Inhibition of PI3K/Akt Pathway

Related Author

Xin-yao ZHANG

Jian LIU

Ning JI

Jin-hua FENG

Wan-qi WANG

Kai JIANG

Rui WEI

Yan-hong YUAN

Related Institution

Changchun University of Chinese Medicine

Affiliated Hospital of Changchun University of Chinese Medicine

Henan Province Hospital of Traditional Chinese Medicine (TCM)

Chengdu University of TCM

Hubei Key Laboratory of Resource and Chemistry of Chinese Medicine，School of Pharmacy， Hubei University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰