Clinical Efficacy and Mechanism of Modified Erxian Decoction in Treating Osteoporosis with Yang Deficiency

Shi-zhou CHEN; Guo-qing MAO; Yu-ming SUN; Lu-mei CAO; Long-xiu QIN; Yao YAO; Jian-feng GE

doi:10.13422/j.cnki.syfjx.20192325

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Clinical Efficacy and Mechanism of Modified Erxian Decoction in Treating Osteoporosis with Yang Deficiency

Clinic | 更新时间：2021-02-09

- Clinical Efficacy and Mechanism of Modified Erxian Decoction in Treating Osteoporosis with Yang Deficiency
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 7, Pages: 104-108(2020)
- 作者机构：
  
  南京中医药大学　附属医院，南京　 210029
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192325
  CLC： R22; R242; R2-031;R287
- Received：01 June 2019，
  
  Published Online：19 August 2019，
  
  Published：05 April 2020
- 稿件说明：
移动端阅览
Shi-zhou CHEN, Guo-qing MAO, Yu-ming SUN, et al. Clinical Efficacy and Mechanism of Modified Erxian Decoction in Treating Osteoporosis with Yang Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(7): 104-108.
DOI：

Shi-zhou CHEN, Guo-qing MAO, Yu-ming SUN, et al. Clinical Efficacy and Mechanism of Modified Erxian Decoction in Treating Osteoporosis with Yang Deficiency[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(7): 104-108. DOI： 10.13422/j.cnki.syfjx.20192325.

摘要

目的：

观察加味二仙汤对阳虚质骨质疏松症患者体质状态、腰背部及关节处疼痛、肢体活动状况、骨密度、骨代谢生化指标的影响，对可能的作用机制进行探讨。

方法：

将符合要求的100例阳虚质骨质疏松症患者随机分为治疗组及对照组，各50例。对照组给予基础抗骨质疏松治疗，治疗组用加味二仙汤联合基础治疗，为期6周。记录分析患者治疗前后腰背部与关节处疼痛评分、阳虚症状积分及肢体活动状况(short physical performance battery，SPPB)评分；测定患者治疗前后血清钙(calcium，Ca)，血磷(phosphorus，P)，腰椎1-4(L

1-4

)，股骨颈骨密度(bone mineral density，BMD)，骨钙素(osteocalcin，BGP)及I型前胶原氨基端肽(type 1 procollagen amino terminal peptide，P1NP)水平的变化情况。

结果：

治疗前两组的腰背及关节处疼痛评分，阳虚症状积分，肢体功能活动评分，L

1-4

及股骨颈骨密度，Ca，P，BGP及P1NP比较无统计学差异；治疗6周后，治疗组肢体活动状况评分，L

1-4

及股骨颈骨密度，血清Ca，P水平高于对照组(

0.05)；治疗组腰背部及关节处疼痛评分，阳虚症状积分，BGP及P1NP水平低于对照组(

0.05)。

结论：

加味二仙汤可以显著减轻阳虚质骨质疏松症患者腰背部及关节处疼痛，增强肢体功能活动状况，改善患者体质状态，提高骨密度，降低骨转换，对阳虚质骨质疏松有良好的治疗与改善症状的作用。

Abstract

Objective:

To observe the effect of modified Erxian decoction on the physical condition

pain in the lower back and joints

limb activity

bone density

bone metabolism and biochemical indexes in patients with osteoporosis caused by Yang deficiency

in order to explore the possible mechanism.

Method:

Totally 100 cases of osteoporosis with Yang deficiency were randomly divided into treatment group and control group

with 50 cases in each group. The control group was treated with basic anti-osteoporosis therapy

and the treatment group was give modified Erxian decoction combined with basic therapy for 6 weeks. Short physical performance battery (SPPB) scores of low back and joint pain and Yang deficiency symptom score before and after treatment were recorded and analyzed. before and after treatment

the changes of blood serum calcium (Ca)

phosphorus (P)

1-4

femoral neck bone mineral density(BMD)

osteocalcin (BGP) and type I collagen peptide amino end level (P1NP) were measured.

Result:

The scores of lumbar back and joint pain

Yang deficiency symptom score

limb function and activity

lumbar spine 1-4 (L

1-4

)

femoral neck BMD

BGP and P1NP between two groups before treatment had no statistically significant difference. After 6 weeks of treatment

limb activity score

1-4

femoral neck BMD

serum Ca and P levels in treatment group were significantly higher than those in control group (

0.05). The scores of the pain in the lower back and joints

Yang deficiency symptom score

BGP and P1NP in treatment group were significantly lower than those in control group (

0.05).

Conclusion:

Modified Erxian decoction can significantly alleviate the pain in the lower back and joints of patients with osteoporosis caused by Yang deficiency

enhance the limb function and activity status

improve the physical condition and bone density of patients

reduce bone conversion

with a good effect in treating and alleviating symptoms of osteoporosis caused by Yang deficiency.

关键词

Keywords

references

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