Effect of Zelen' s Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome

Peng SUN; Jian LI; Wei-jun FAN; Ning TANG; Ming-bo SHA; Yu LU; Hua-nan LI; Shu WANG

doi:10.13422/j.cnki.syfjx.20192326

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Effect of Zelen' s Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome

Clinic | 更新时间：2021-02-09

- Effect of Zelen' s Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 9, Pages: 58-63(2020)
- 作者机构：
  
  天津中医药大学　第一附属医院，天津　 300193
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192326
  CLC： R22; R242; R2-031;R287
- Received：02 June 2019，
  
  Published Online：19 August 2019，
  
  Published：05 May 2020
- 稿件说明：
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Peng SUN, Jian LI, Wei-jun FAN, et al. Effect of Zelen' s Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(9): 58-63.
DOI：

Peng SUN, Jian LI, Wei-jun FAN, et al. Effect of Zelen' s Guige Lingxian Decoction Combined with Moxibustion at Neck Jiaji Acupoint in Treatment of Cervical Spondylotic radiculopathy of Wind-cold-dampness Arthralgia Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(9): 58-63. DOI： 10.13422/j.cnki.syfjx.20192326.

摘要

目的：

基于Zelen' s设计，探讨桂葛灵仙汤联合夹脊穴透灸法治疗神经根型颈椎病(CSR)风寒湿痹证临床疗效及作用机制。

方法：

将120例CSR风寒湿痹证患者随机分为中药组和联合组，均60例，拟入中药组直接进入中药组，拟入联合组知情同意则进入联合组，不同意则进入中药组。中药组给予桂葛灵仙汤150 mL/次，2次/d口服，联合组患者在中药组治疗基础上给予颈部夹脊穴透灸治疗，30 min/次，1次/d，两组患者均治疗8周。记录入组患者CSR 20分量表评分，SF-36量表评分及典型症状体征缓解时间，治疗结束后统计总有效率和治愈率；酶联免疫夹心法检测治疗前后患者血清白三烯B

(LTB

)，白三烯C

(LTC

)，白三烯D

(LTD

)，甲壳质酶蛋白-40(YKL-40)，白细胞介素-1

(IL-1

)及肿瘤坏死因子-

(TNF-

)含量。

结果：

联合组总有效率为98.11%(52/53)，治愈率为43.39%(23/52)，优于中药组总有效率91.04%(61/69)，治愈率20.89%(14/67)(

0.05)；与中药组比较，联合组患者CSR 20分量表，SF-36量表评分升高(

0.05)，典型症状体征缓解时间缩短(

0.05)；血清中LTB

，LTC

，LTD

，YKL-40，IL-1

及TNF-

含量降低(

0.05)。

结论：

Zelen' s设计结果显示桂葛灵仙汤联合夹脊穴透灸法治疗CSR风寒湿痹证临床疗效确切，值得临床推广，其机制可能与抑制LT表达，减少IL-1

及TNF-

含量在血清中含量，从而促进颈椎软骨修复和提高疼痛阈值有关。

Abstract

Objective:

To investigate the clinical efficacy and mechanism of Guige Lingxian decoction combined with moxibustion at neck Jiaji acupoint on cervical spondylotic radiculopathy (CSR) of wind-cold-dampness arthralgia syndrome.

Method:

Totally 120 cases of cervical spondylotic radiculopathy with wind-cold-dampness syndrome were randomly divided into two groups: traditional Chinese medicine(TCM) group and combination group

with 60 cases in each group. The TCM group was treated with Guige Lingxian Tang 150 mL/time

twice a day. The combination group was treated with moxibustion at neck Jiaji acupoint in addition to the therapy of the TCM group

30 minutes/time

once a day. Both groups were treated for 8 weeks. CSR 20 subscale score

SF-36 scale score

typical symptoms and signs remission time were recorded. The total effective rate and the cure rate were recorded after treatment. Serum levels of leukotriene B

(LTB

)

leukotriene C

(LTC

)

leukotriene D

(LTD

)

chitinase protein 40 (YKL-40)

interleukin-1

(IL-1

) and tumor necrosis factor-

(TNF-

) were measured by enzyme linked immunosorbent assay(ELISA) before and after treatment.

Result:

The total effective rate was 98.11%(52/53)

and the cure rate was 43.39%(23/53) in the combination group

which were higher than 91.04%(61/67) and 20.89%(14/67) in the TCM group (

0.05). Compared with the TCM group

the scores of CSR 20 subscale and SF-36 scale in combination group were increased (

0.05)

and the remission time of typical symptoms and signs was shortened. Serum levels of LTB

LTC

LTD

YKL-40

IL-1

and TNF-

were decreased (

0.05).

Conclusion:

Moxibustion at neck Jiaji acupoint combined with Guige Lingxian decoction is effective in treating CSR of wind-cold-dampness arthralgia syndrome

which is worthy of clinical promotion. Its mechanism may be related to the inhibition of the expression of LT

and the reduction of the content of IL-1

and TNF-

in serum

thus promoting the repair of cervical cartilage and increasing the pain threshold.

关键词

Keywords

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