Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome

Hua HU; Lian-tai LI; Yan-wei LIU; Shu-jun WANG; Shuang-xi XIE; Jian-jun SUN

doi:10.13422/j.cnki.syfjx.20192333

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Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome

Clinic | 更新时间：2021-02-09

- Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 6, Pages: 97-102(2020)
- 作者机构：
  
  承德医学院　附属医院，河北承德　 067000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192333
  CLC： R24; R274; R274.9; R289
- Received：07 August 2019，
  
  Published Online：25 September 2019，
  
  Published：20 March 2020
- 稿件说明：
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Hua HU, Lian-tai LI, Yan-wei LIU, et al. Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 97-102.
DOI：

Hua HU, Lian-tai LI, Yan-wei LIU, et al. Effect of Modified Simiaosan on Inflammatory Factors and Neuropeptide Substances of Patients with Synovitis of Knee Joint and Damp-heat Obstruction Collateral Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 97-102. DOI： 10.13422/j.cnki.syfjx.20192333.

摘要

目的：

观察四妙散加味对膝关节滑膜炎(KS)湿热阻络证的临床疗效及对关节液炎性因子和神经肽物质的影响。

方法：

将135例患者分为对照组67例和观察组68例。对照组抽净关节内积液后，以曲安奈德注射液关节内注射，1周1次，共2次，并口服醋氯芬酸缓释片，0.2 g/次，1次/d。观察组西医治疗措施同对照组，并内服四妙散加味，1剂/d，两组疗程均为连续治疗4周。进行治疗前后膝关节疼痛和肿胀程度评分，膝关节功能采用美国西安大略和麦克马斯特大学骨关节炎评分(WOMAC)，进行治疗前后湿热阻络证和膝关节局部体征评价；检测治疗前后关节液白细胞介素-1

(IL-1

)，IL-6，肿瘤坏死因子-

(TNF-

)，超敏C反应蛋白(hs-CRP)，P物质(SP)，钙素基因相关肽(CGRP)，神经肽Y(NPY)和血管活性肠肽(VIP)水平。

结果：

治疗后观察组膝关节疼痛程度和肿胀程度均低于对照组(

0.01)；观察组WOMAC量表各因子评分和总分均低于对照组(

0.01)；观察组湿热阻络证积分、膝关节屈伸范围评分和浮髌试验评分均低于对照组(

0.01)；观察组关节液IL-1

，IL-6，TNF-

和hs-CRP水平均低于对照组(

0.01)；观察组关节液SP，CGRP，NPY和VIP水平均低于对照组(

0.01)；经秩和检验，观察组临床疗效优于对照组(

＝2.089，

0.05)。

结论：

四妙散加味治疗KS湿热阻络证患者，能明显减轻疼痛、肿胀症状，促进膝关节活动功能恢复，并能抑制关节液中促炎因子和神经肽类物质表达，提高了临床治疗效果。

Abstract

Objective:

To observe the clinical efficacy of modified Simiaosan on synovitis of knee joint with damp-heat obstruction collateral syndrome and the effect on inflammatory factors and neuropeptide substances in synovial fluid.

Method:

One hundred and thirty-five patients were randomly divided into control group(67 cases) and observation group(68 cases) by random number table. Patients' intra-articular effusion was drawn out. Triamcinolone acetonide was injected into arthrosis for 2 times

1 time/week

and aceclofenac sustained-release tablets were given for 4 weeks

0.2 g/time

1 time/day. In addition to the therapy of control group

patients in observation group were also given modified Simiaosan for 4 weeks

1 dose/day. Before and after treatment

pain

swelling of knee joint and were scored

Western Ontario and McMaster University (WOMAC) were adopted for scoring knee score

and damp-heat obstruction syndrome and local signs of knee joint were also assessed. And levels of interleukin-1 beta (IL-1 beta)

IL-6

tumor necrosis factor-alpha (TNF-alpha)

hypersensitive C-reactive protein (hs-CRP)

substance P (SP)

calcitonin gene-related peptide (CGRP)

neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) were detected.

Result:

After treatment

scores of pain and swelling of knee joint in observation group were lower than those in control group (

0.01). Scores of WOMAC

the total score

integral of damp-heat obstruction collateral syndrome

knee flexion-extension range score and floating patella test were all lower than those in control group (

0.01). And levels of IL-1

IL-6

TNF-

hs-CRP

CGRP

NPY and VIP were all lower than those in control group (

0.01). Analyzed by rank sum test

the clinical efficacy in observation group was better than those in control group (

=2.089

0.05).

Conclusion:

Modified Simiaosan can significantly alleviate pain and swelling symptoms

promote the recovery of knee joint function

and inhibit the expressions of proinflammatory factors and neuropeptides in synovial fluid

with a better clinical efficacy.

关键词

Keywords

references

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Related Institution

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