Clinical Efficacy of Modified Bingtitang in Treatment of Type 2 Diabetes Mellitus and Effect on Pancreas Islet Function

Tian-ci SUN; Wen LI; Fen LIU; Xin-qiao KE; Li YANG

doi:10.13422/j.cnki.syfjx.20192421

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Clinical Efficacy of Modified Bingtitang in Treatment of Type 2 Diabetes Mellitus and Effect on Pancreas Islet Function

Clinic | 更新时间：2021-02-09

- Clinical Efficacy of Modified Bingtitang in Treatment of Type 2 Diabetes Mellitus and Effect on Pancreas Islet Function
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 25, Issue 24, Pages: 60-64(2019)
- 作者机构：
  
  深圳市龙华区中心医院，广东　深圳　 518110
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192421
  CLC： R22; R242; R2-031;R287
- Received：04 July 2019，
  
  Published Online：03 September 2019，
  
  Published：20 December 2019
- 稿件说明：
移动端阅览
Tian-ci SUN, Wen LI, Fen LIU, et al. Clinical Efficacy of Modified Bingtitang in Treatment of Type 2 Diabetes Mellitus and Effect on Pancreas Islet Function[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(24): 60-64.
DOI：

Tian-ci SUN, Wen LI, Fen LIU, et al. Clinical Efficacy of Modified Bingtitang in Treatment of Type 2 Diabetes Mellitus and Effect on Pancreas Islet Function[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(24): 60-64. DOI： 10.13422/j.cnki.syfjx.20192421.

摘要

目的：

探讨并提汤加减治疗2型糖尿病(T2DM)临床疗效及对患者胰岛功能的影响。

方法：

将108例T2DM患者按照随机数字表法分为对照组和治疗组，每组54例。对照组给予糖尿病饮食、适量运动、控制血糖等糖尿病常规治疗，治疗组在对照组治疗基础上应用并提汤加减口服。比较两组患者治疗前后血糖、胰岛功能相关指标、中医证候积分、血清视黄醇结合蛋白4(RBP4)，Betatrohin水平，并比较治疗总有效率。

结果：

治疗后治疗组空腹血糖(FPG)，糖化血红蛋白(HbA1c)，血糖变异系数(CV-FPG)，胰岛素抵抗指数(HOMA-IR)低于对照组(

0.01)，胰岛素分泌指数(HOMA-IS)，30 min胰岛素增值(I30)和血糖增值(G30)之比(

I30/

G30)高于对照组(

0.01)，各项中医证候积分低于对照组(

0.01)；血清RBP4水平低于对照组(

0.01)，Betatrohin水平高于对照组(

0.01)，治疗组总有效率高于对照组(

0.05)。

结论：

在常规治疗基础上，应用并提汤加减可有效控制血糖，改善胰岛功能，缓解中医证候，治疗T2DM效果确切，其机制可能与调节血清RBP4，Betatrohin水平有关。

Abstract

Objective:

To investigate the clinical efficacy of modified Bingtitang in treatment of type 2 diabetes mellitus(T2DM) and its effect on pancreas islet function.

Method:

A total of 108 patients with T2DM were divided into two groups according to the digital number table method

with 54 cases in each group. The control group were given routine therapy of diabetic diet

proper exercise and blood sugar control

while the treatment group were orally given traditional Chinese medicine(TCM) and modified Bingtitang in addition to the therapy of the control group. The blood sugar

pancreas islet function-related indexes

TCM syndrome score

serum retinol binding protein 4 (RBP4) and Betatrohin levels were compared between two groups before and after treatment. The total effective rate was also compared.

Result:

After treatment

the fasting blood glucose (FPG)

glycated hemoglobin (HbA1c)

blood glucose variation coefficient (CV-FPG)

insulin resistance index (HOMA-IR) of the treatment group were lower than those of control group (

0.01)

while the ratio of insulin secretion index (HOMA-IS)

30-minute insulin increment (I30) and blood glucose proliferation (G30) to(

I30 /

G30)of treatment group were higher than those of the control group (

0.01). The TCM score and the serum RBP4 level were lower than those of control group (

0.01)

while Betatrohin level was higher than that of the control group (

0.01)

and the total effective rate was higher than that of control group (

0.05).

Conclusion:

In addition to the routine treatment

modified Bingtitang can effectively control blood sugar

improve pancreas islet function

and alleviate TCM syndromes

with a significant effect on T2DM. Its mechanism may be related to the regulation of serum RBP4 and Betatrohin levels.

关键词

Keywords

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