Toxicological Technology in Evaluation and Application of Traditional Chinese Medicine Healthcare Food

Han LI; Guang-ping ZHANG; Lei LEI; Teng-fei CHEN; Zu-guang YE

doi:10.13422/j.cnki.syfjx.20192423

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Toxicological Technology in Evaluation and Application of Traditional Chinese Medicine Healthcare Food

Review | 更新时间：2021-02-09

- Toxicological Technology in Evaluation and Application of Traditional Chinese Medicine Healthcare Food
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 6, Pages: 201-208(2020)
- 作者机构：
  
  1.中国中医科学院　中药研究所，北京　 100700
  2.中国中医科学院　中医药信息研究所，北京　 100700
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20192423
  CLC： R22; R242; R2-031; R285.5;R287
- Received：14 May 2019，
  
  Published Online：03 September 2019，
  
  Published：20 March 2020
- 稿件说明：
移动端阅览
Han LI, Guang-ping ZHANG, Lei LEI, et al. Toxicological Technology in Evaluation and Application of Traditional Chinese Medicine Healthcare Food[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 201-208.
DOI：

Han LI, Guang-ping ZHANG, Lei LEI, et al. Toxicological Technology in Evaluation and Application of Traditional Chinese Medicine Healthcare Food[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 201-208. DOI： 10.13422/j.cnki.syfjx.20192423.

摘要

我国中医药宝库含有丰富的可以药食两用的中药，以该类中药作为原料是指导中药保健食品研制的基础。在养生和降低疾病发生风险方面，中药保健食品具有诸多优势。同时伴随国家“健康中国2030”的实施，急需开发一系列具有中医药特点的中药复方保健食品，满足国家及社会需求。随着现代化科学研究水平不断提高，但是中药保健食品原料的安全性科学评价方面研究缺乏，造成目前保健食品风险评估理论与技术严重不足。因此对此这类原料中重要成分的毒性预警与评价已成为的食品安全问题的当务之急。毒理学在人类健康风险评估中具有重要作用，毒理学的分支学科也不断涌现。计算毒理学技术，单层培养细胞模型的体外预警与评价技术，体外诱导活性筛选工程细胞株的体外预警与评价技术，微流控芯片技术的体外预警与评价技术与体内毒理学技术等已成为该领域毒性预测与评价的重要研究工具。毒理学技术的迅速发展，使食品安全和人类生命健康得到有力的保障，并将有效促进我国保健食品产业的安全生产，保障终端产品的品质和安全，不仅具有巨大社会意义，也对整个行业的技术进步有积极的引领作用，并产生可观的经济效益。本文就近段时间以来可用于预测与评价中药保健食品原料中的重要成分的毒理学新方法与模型的研究进展与应用作一综述。

Abstract

China is rich in herbs that can be used as medicine and food. The application of this kind of traditional Chinese medicine (TCM) as raw material is the basis for guiding the development of TCM healthcare food. TCM healthcare food has advantages in keeping in good health and reducing the risk of disease. At the same time

with the implementation of " Healthy China 2030"

it is urgent to develop a series of herbal compound healthcare food with the characteristics of TCM to meet the national and social needs. With the development of scientific research

however

there is a lack of research on the scientific evaluation of the safety of TCM healthcare food raw materials

which results in insufficient risk assessment theory and technology of healthcare food at present. Therefore

the prediction and evaluation of the toxicity of important components in this kind of raw materials has become an urgent task of food safety. Toxicology plays an important role in human health risk assessment

and its sub-disciplines have been constantly emerging. Computational toxicology

monolayer culture cell model technology

in vitro

induced activity screening engineering cell technology

microfluidic chip technology and

in vivo

toxicology technology have become important research tools for toxicity prediction and evaluation in this field. With the rapid development of toxicology technology

food safety and human life and health can be effectively guaranteed. It will effectively promote the safety production of healthcare food industry in China and guarantee the quality and safety of terminal products. It has a great social significance

plays a positive leading role in the technological progress of the whole industry

and generates considerable economic benefits. This paper reviews recent advances and applications of new toxicological methods and models for predicting and evaluating important ingredients in TCM healthcare food raw materials.

关键词

Keywords

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