Effect of Wenjingtang on Levels of Serum Platelet Activating Factor and <italic style="font-style: italic">β</italic>-endorphins in Primary Dysmenorrhea Patients with Cold Stagnation and Blood Stasis Syndrome

Meng SUN; Yang ZHAO; Dong-xia YANG

doi:10.13422/j.cnki.syfjx.20200221

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Effect of Wenjingtang on Levels of Serum Platelet Activating Factor and β-endorphins in Primary Dysmenorrhea Patients with Cold Stagnation and Blood Stasis Syndrome

Classic Prescriptions | 更新时间：2021-04-16

- Effect of Wenjingtang on Levels of Serum Platelet Activating Factor and β-endorphins in Primary Dysmenorrhea Patients with Cold Stagnation and Blood Stasis Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 2, Pages: 1-5(2020)
- 作者机构：
  
  黑龙江中医药大学　附属第二医院，哈尔滨　 150001
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20200221
  CLC： R22; R242; R2-031;R287; R711
- Received：16 July 2019，
  
  Published Online：09 October 2019，
  
  Published：20 January 2020
- 稿件说明：
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Meng SUN, Yang ZHAO, Dong-xia YANG. Effect of Wenjingtang on Levels of Serum Platelet Activating Factor and β-endorphins in Primary Dysmenorrhea Patients with Cold Stagnation and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(2): 1-5.
DOI：

Meng SUN, Yang ZHAO, Dong-xia YANG. Effect of Wenjingtang on Levels of Serum Platelet Activating Factor and β-endorphins in Primary Dysmenorrhea Patients with Cold Stagnation and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(2): 1-5. DOI： 10.13422/j.cnki.syfjx.20200221.

摘要

目的：

观察温经汤对寒凝血瘀型原发性痛经患者血清血小板活化因子(PAF)以及

-内啡肽影响。

方法：

选取2016年3月至2017年12月黑龙江中医药大学附属第二医院收治的120例痛经患者为研究对象，患者按随机数字法被分成对照组和观察组，各60例。对照组患者服用布洛芬缓释胶囊，观察组在对照组基础上服用温经汤。对比两组患者治疗前及治疗后的痛经症状积分、临床疗效、血清PAF和

-内啡肽水平和复发情况。

结果：

治疗后，两组患者痛经症状评分均下降，且观察组患者评分均低于对照组(

0.05)。治疗后，观察组患者总有效率95.00%，高于对照组的83.33%(

0.05)。与本组治疗前比较，治疗后两组患者血清PAF水平下降，且观察组患者血清PAF低于对照组(

0.05)。与本组治疗前比较，两组治疗后血清

-内啡肽水平上调，且治疗后观察组血清

-内啡肽高于对照组(

0.05)；半年后随访，观察组患者复发3例，复发率为5%；对照组复发18例，复发率为30%。观察组复发率与对照组相比显著降低(

＝12.987，

0.01)。

结论：

温经汤治疗寒凝血瘀型原发性痛经能有效降低痛经症状积分，改善临床症状，降低血清PAF水平，上调

-内啡肽浓度，减少复发率，改善患者生活质量，值得推广。

Abstract

Objective:

To explore the effect of Wenjingtang on the levels of serum platelet activating factor (PAF) and

-endorphins in primary dysmenorrhea patients with cold stagnation and blood stasis syndrome.

Method:

The 120 cases of dysmenorrhea treated at Second Affiliated Hospital

Heilongjiang University of Chinese Medicine from March 2016 to December 2017 were selected as the observation subjects

and divided into control group and observation group according to the random number table method

with 60 cases in each group. The control group was treated with ibuprofen capsules

while the observation group was treated with Wenjingtang and ibuprofen capsules. Dysmenorrhea symptom scores

clinical efficacy

recurrence condition and serum levels of platelet activating factor and

-endorphins were compared before and after treatment.

Result:

After treatment

the dysmenorrhea symptom scores decreased significantly in both groups

and the scores of patients in observation group were lower than those in control group (

0.05). After treatment

the total efficiency in observation group was 95%

which was significantly higher than 83.33% in control group (

0.05). The level of serum PAF decreased significantly in two groups

and the serum PAF in observation group was significantly decreased compared with control group (

0.05). The level of serum beta-endorphins in observation group was significantly higher than that of control group (

0.05). After half a year

the recurrence rate of the observation group was 5%

which was significantly lower than 30% of control group (

=12.987

0.01).

Conclusion:

Wenjingtang contributes to the reduction of dysmenorrhea symptoms scores in primary dysmenorrhea patients with cold stagnation and blood stasis syndrome

and can improve the clinical efficacy

reduce the serum PAF level and increase the concentration of

-endorphins

reduce the recurrence rate

improve the quality of life of patients

and it is worth promoting.

关键词

Keywords

references

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Effect of Wenjingtang on Levels of Serum Platelet Activating Factor and β-endorphins in Primary Dysmenorrhea Patients with Cold Stagnation and Blood Stasis Syndrome

DOI：10.13422/j.cnki.syfjx.20200221

摘要

Abstract

关键词

Keywords

references