Objective:

2

To observe the efficacy of modified Qiju Dihuang pills in protecting renal function of patients with early renal impairment with syndrome of Yin deficiency and Yang hyperactivity caused by hypertension and its effect in resisting inflammation and oxidative stress

and improving endothelial function.

Method:

2

Randomly divided into control group (59 cases) and observation group (60 cases) by random number table. Patients in control got valsartan capsules

80 mg/time

1 time/day. And patients whose blood pressure can't be controlled were added with nifedipine tablets

10 mg/time

1 time/day. In addition to the therapy of control group

patients in observation group were added with modified Qiju Dihuang pills

1 dose/day. The control group took Qiju Dihuang pills.The courses of treatment were 16 weeks. And levels of cystatin C (CysC)

urinary

N

-acetyl-

β

-glucosaminidase (NAG)

β

2

microglobulin (

β

2

-MG)

urinary microalbumin to creatinine ratio (UACR) and emodynamics of kidney were detected. Blood pressure

systolic pressure (SBP)

diastolic pressure (DBP) and blood pressure renal artery resistance index (RI) and pulsatility index (PI) were recorded

and Yin deficiency and Yang hyperactivity were scored. Levels of nitric oxide (NO)

endothelin-1 (ET-1)

superoxide dismutase (SOD)

glutathione peroxidase (GSH-Px)

interleukin-6 (IL-6)

tumor necrosis factor-alpha (TNF-

α

)

adiponectin (ADPN) and nuclear factor-kappa B (NF-

κ

B) were detected.

Result:

2

The total effective rate in observation group was 91.67%(55/60)

which was higher than 76.27%(45/59) in control group (

χ

2

=5.255

P

<

0.05). Levels of SBP and DBP were lower than those in control group (

P

<

0.05). At the 16

th

week during the treatment

the compliance rate of blood pressure was 90.66%

which was higher than 84.13% in control group (

χ

2

=127.65

P

<

0.01). And levels of CysC

β

2

-MG

NAG

UACR

RI

PI

ET-1

SOD

GSH-Px

IL-6

NF-

κ

B and TNF-

α

were lower than those in control group (

P

<

0.01)

while levels of NO

SOD and GSH-Px were higher than those in control group (

P

<

0.01).

Conclusion:

2

In addition to the therapy for controlling blood pressure with routine western medicine

modified Qiju Dihuang pills can reduce level of the blood pressure

and control blood pressure with the standard

with anti-inflammatory and anti-oxidative stress effects. It can also improve the vasomotor function and the flow of kidney

protect the kidney function

and reduce the degree of injury

so as to delay the process of kidney damage and improve the prognosis.