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1.中国中医科学院 中药研究所,北京 100700
2.云南曲焕章生物科技有限公司,昆明 650106
Received:02 October 2019,
Published Online:08 October 2019,
Published:20 April 2020
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Kang NING, Lin-lin DONG, Meng-zhi LI, et al. Application and Development of Non-psychoactive Medicinal Cannabis[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(8): 228-240.
Kang NING, Lin-lin DONG, Meng-zhi LI, et al. Application and Development of Non-psychoactive Medicinal Cannabis[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(8): 228-240. DOI: 10.13422/j.cnki.syfjx.20200348.
非精神活性药用大麻即四氢大麻酚(THC)质量分数<0.3%且大麻二酚(CBD)含量高(原则上应>2.0%),主要用于药用的大麻植物。大麻的药用性历史悠久,笔者基于大麻的本草考证以及国际药用历史,阐述了大麻素类化合物特别是CBD在开发抗癫痫药品、精神疾病药品、镇痛抗炎药品及抗肿瘤药品上的应用,并对其在食品、保健品、化妆品等领域的应用情况进行总结。基于目前高CBD含量药用大麻的新品种匮乏、基础研究薄弱等问题,建议应加强CBD等有效成分的基础研究,推动药用大麻五类新药及保健品等的开发,通过挖掘药用大麻遗传信息,建立其综合鉴定体系并加快高CBD含量新品种选育,保障药用大麻的安全性及有效性,促进药用大麻产业的可持续发展。
Non-psychoactive medicinal cannabis is the cannabis that contain less than 0.3% of tetrahydrocannabinol (THC) and high content of cannabidiol (CBD) (more than 2.0% is reasonable)
and mainly used for medicinal purpose. Cannabis have a long medical history
in this review
we retrospected the medicinal history of cannabis in China and the world. We summarized the cannabinoid especially CBD application of medicine in epilepsy
mental disease
tumor
analgesic and inflammatory
also the widely application in food
healthy products
cosmetics and other fields. Based on the problems like shortage of high CBD cultivars
weakness of fundamental research existed in non-psychoactive medicinal cannabis industry. We should fully utilize the genetic information of medicinal cannabis
establish the comprehensive identification system of non-psychoactive medicinal cannabis varieties
accelerate the breeding process of non-psychoactive medicinal cannabis cultivars
to ensure the safety and effectiveness of non-psychoactive medicinal cannabis. Strengthen the basic research on CBD and other cannabinoids to promote the application of non-psychoactive medicinal cannabis products and sustainable development of medical cannabis industry.
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