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Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 10, Pages: 227-234(2020)
- 作者机构：
1.安徽中医药大学，合肥 230038
2.合肥医工医药股份有限公司，合肥 230601
- 作者简介：
- 基金信息：
DOI：10.13422/j.cnki.syfjx.20200405
CLC： R2-0; R22; R285.5; R284Received：02 September 2019，
Published Online：05 November 2019，
Published：20 May 2020
- 稿件说明：
移动端阅览
Xiang WANG, Jia-jia MO, Peng ZHOU, et al. Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 227-234.
Xiang WANG, Jia-jia MO, Peng ZHOU, et al. Effect of Traditional Chinese Medicine and Its Active Ingredients on Cardiovascular Disease Based on Nrf2/HO-1 Signaling Pathway[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 227-234. DOI： 10.13422/j.cnki.syfjx.20200405.
摘要
心血管疾病是我国居民死亡的首要原因，因其在遗传背景、发病原因、疾病发展走向等方面存在非常大的个体差异性，目前指南指导下的西医规范化治疗的残存死亡风险率仍然很高。中药具有多靶点、多途径、多层次的独特优势，可有效弥补西药的不足，在心血管疾病的治疗中被广泛应用。氧化应激是导致心血管疾病发生的重要原因之一，核因子E2相关因子2(Nrf2)是该反应的中枢调节者，当其被激活后可向核内转移并启动下游通路信号传导，发挥抗氧化应激作用。作为机体最重要的内源性保护体系之一，Nrf2/血红素加氧酶-1(Nrf2/HO-1)信号通路是Nrf2发挥作用的最经典途径。近年来运用现代分子生物学等方法研究并阐明中药通过调控该通路治疗心血管疾病已取得一定的成果。基于此，本文总结了Nrf2/HO-1信号通路与心血管疾病的关系，并归纳分析了中药有效成分、中药药对有效成分、中药提取物及中药复方调节该信号通路干预心血管疾病的的作用方式及可能机制，以期为抗心血管疾病药物的研发与利用提供理论参考。
Abstract
Cardiovascular disease is the leading cause of death in China. Due to its great individual differences in genetic background
pathogenesis and disease development trend
the survival risk rate after standardized western medicine treatment under the guidance of the current guidelines remains high. Traditional Chinese medicine(TCM) has unique multiple-target
multiple-pathway and multiple-layer advantages
which can effectively make up for shortcomings of western medicine. Therefore
it has been widely used in the treatment of cardiovascular diseases. Oxidative stress is one of the important causes of cardiovascular diseases. Nuclear factor erythroid-2-related factor 2(Nrf2) is the central regulator of this reaction. When being activated
it can transfer to the nucleus and initiate signaling in the downstream pathway
thus playing an anti-oxidative stress role. As one of the most important endogenous protection systems in the body
the Nrf2/heme oxygenase-1 (Nrf2/HO-1) signaling pathway is the most classical approach for Nrf2 in playing roles. There have been certain achievements in studying and clarifying TCM by regulating this pathway to treat cardiovascular diseases using modern molecular biology and other methods. Based on this
this paper summarized the relationship between Nrf2/HO-1 signaling pathway and cardiovascular diseases
then concluded and analyzed the mechanism and pharmacological effects of TCM and its active ingredients in Nrf2/HO-1 signaling pathway on different cardiovascular diseases
involving active ingredients of TCM
TCM pairs active ingredients
TCM extracts and TCM formula. This paper provides a theoretical reference for the development and utilization of anti-cardiovascular drugs.
关键词
Keywords
references
D MOZAFFARIAN , E J BENJAMIN , A S GO , et al . Executive summary: heart disease and stroke statistics-2016 update：a report from the American Heart Association [J]． Circulation ， 2016 ， 133 ( 4 )： 447 - 454 .
H LEI , J J GUO , F XU , et al . Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodelingafter acute myocardial infarction：involvement in oxidative stress and apoptosis [J]． Basic Res Cardiol ， 2018 ， 113 ( 4 )： 28 .
C WANG , Y YUAN , J WU , et al . Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress [J]． Free Radic Biol Med ， 2019 ， 141 ： 372 - 382 .
C A H SEVERENS-RIJVERS , S AL-NASIRY , A VINCKEN , et al . Early-pregnancy circulating antioxidant capacity and hemodynamic adaptation in recurrent placental syndrome：an exploratory study [J]． Gynecol Obstet Invest ， 2019 ， doi： 10.1159/000501254 http://dx.doi.org/10.1159/000501254 .
苏成福 ， 龚曼 ， 韩永光 ， 等 ． 葛根总黄酮对氧化应激损伤人脐静脉内皮细胞的保护作用及其机制 [J]． 中国实验方剂学杂志 ， 2018 ， 24 ( 23 )： 159 - 164 .
A LOBODA , M DAMULEWICZ , E PYZA , et al . Role of Nrf2/HO-1 system in development，oxidative stress response and diseases: an evolutionarily conserved mechanism [J]． Cell Mol Life Sci ， 2016 ， 73 ( 17 )： 3221 - 3247 .
L DUAN , X J XIONG , J Y HU , et al . Efficacy and safety of oral Panax Notoginseng saponins for unstable angina patients: a meta-analysis and systematic review [J]． Phytomedicine ， 2018 ， 47 ： 23 - 33 .
章轶立 ， 王娟 ， 李园 ， 等 ． 芪参益气滴丸治疗慢性心力衰竭(气虚血瘀证)的Meta分析 [J]． 中国实验方剂学杂志 ， 2019 ， 25 ( 21 )： 162 - 169 .
H YU , L SHI , S ZHAO , et al . Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway [J]． Cardiovasc Toxicol ， 2016 ， 16 ( 4 )： 325 - 335 .
王甜甜 ， 陈淳媛 ， 杨雷 ， 等 ． Nrf2/HO-1信号轴在氧化应激性疾病中的机制 [J]． 中南大学学报：医学版 ， 2019 ， 44 ( 1 )： 74 - 80 .
Q M CHEN , A J MALTAGLIATI ． Nrf2 at the heart of oxidative stress and cardiac protection [J]． Physiol Genomics ， 2018 ， 50 ( 2 )： 77 - 97 .
I BELLEZZA , I GIAMBANCO , A MINELLI , et al . Nrf2-Keap1 signaling in oxidative and reductive stress [J]． Biochim Biophys Acta Mol Cell Res ， 2018 ， 1865 ： 721 - 733 .
W CUI , B LENG , G WANG ． Klotho protein inhibits H 2 O 2 -induced oxidative injury in endothelial cells via regulation of PI3K/Akt/Nrf2/HO-1 Pathways [J]． Can J Physiol Pharmacol ， 2019 ， 97 ( 5 )： 1 - 31 .
C ZHAO , Y ZHANG , H LIU , et al . Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf2 pathway regulation [J]． Biochem Biophys Res Commun ， 2017 ， 490 ( 2 )： 552 - 559 .
A K RUOTSALAINEN , M INKALA , M E PARTANEN , et al . The absence of macrophage Nrf2 promotes early atherogenesis [J]． Cardiovasc Res ， 2013 ， 98 ： 107 - 115 .
R ERKENS , C M KRAMER , W LÜCKSTÄDT , et al . Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a，and preserved endothelial function [J]． Free Radic Biol Med ， 2015 ， 89 ： 906 - 917 .
J STROM , B XU , X TIAN , et al . Nrf2 protects mitochondrial decay by oxidative stress [J]． FASEB J ， 2016 ， 30 ： 66 - 80 .
C RAFAEL , R DANIEL , P CAMILA , et al . Nrf2 as a potential mediator of cardiovascular risk in metabolic diseases [J]． Front Pharmacol ， 2019 ， doi： 10.3389/fphar.2019.00382 http://dx.doi.org/10.3389/fphar.2019.00382 .
H QIAO , X SAI , L GAI , et al . Association between heme oxygenase 1 gene promoter polymorphisms and susceptibility to coronary artery disease: a huge review and meta-analysis [J]． Am J Epidemiol ， 2014 ， 179 ： 1039 - 1048 .
Y KISHIMOTO , K KONDO , Y MOMIYAMA ． The protective role of heme oxygenase-1 in atherosclerotic diseases [J]． Int J Mol Sci ， 2019 ， 20 ( 15 )： 3628 .
G WANG , T HAMID , R J KEITH , et al . Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart [J]． Circulation ， 2010 ， 121 ( 17 )： 1912 - 1925 .
Y CHEN , J T SAARI , Y J KANG ． Weak antioxidant defenses make the heart a target for damage in copper-deficient rats [J]． Free Radic Biol Med ， 1994 ， 17 ： 529 - 536 .
R KOSURU , V KANDULA , U RAI , et al . Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/NRF2/HO-1 pathway in fructose-fed diabetic rats [J]． Cardiovasc Drugs Ther ， 2018 ， 32 ( 2 )： 147 - 163 .
L WANG , G W CAI , L DING , et al . Effects of Xin-Ji-Er-Kang on anti-cardiovascular remodeling in-name induced hypertensive mice and its potential mechanisms [J]． Evid Based Complement Alternat Med ， 2018 ， doi： 10.1155/2018/8067361 http://dx.doi.org/10.1155/2018/8067361 .
杨艺萱 ， 张兆芳 ， 刘卉 ， 等 ． 当归红芪超滤物对辐射后心肌成纤维细胞的增殖和胶原分泌的影响 [J]． 中国实验方剂学杂志 ， 2018 ， 24 ( 12 )： 136 - 142 .
L L GU , P YE , H L LI , et al . Lunasin attenuates oxidant-induced endothelial injury and inhibits atherosclerotic plaque progression in ApoE2/2 mice by up-regulating heme oxygenase-1 via PI3K/Akt/Nrf2/ARE pathway [J]． FASEB J ， 2019 ， doi： 10.1096/fj.201802251R http://dx.doi.org/10.1096/fj.201802251R .
栾博 ， 栾梅 ， 邱雅慧 ， 等 ． 葛根素激活Nrf2通路减轻心力衰竭大鼠氧化应激损伤的研究 [J]． 现代预防医学 ， 2019 ， 46 ( 10 )： 1852 - 1856 .
李雪亮 ， 陈兰英 ， 官紫祎 ， 等 ． 降香新黄酮latifolin对大鼠急性心肌缺血影响及介导Nrf2信号通路机制研究 [J]． 中国中药杂志 ， 2017 ， 42 ( 20 )： 3974 - 3982 .
张妮 ， 陈兰英 ， 骆瑶 ， 等 ． 降香新黄酮latifolin通过Nrf2/HO-1通路抗H9C2细胞缺氧复氧损伤作用研究 [J]． 中药材 ， 2019 ， 42 ( 7 )： 1630 - 1634 .
S LI , Y SUN , Z HAN , et al . Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediatedvia Nrf2 [J]． Life Sci ， 2019 ， 223 ： 174 - 184 .
T T ZHAO , T L YANG , L GONG , et al . Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes [J]． Gene ， 2018 ， 666 ： 92 - 99 .
Y LUO , S LU , X DONG , et al . Dihydromyricetin protects human umbilical vein endothelial cells from injury through ERK and Akt mediated Nrf2/HO-1 signaling pathway [J]． Apoptosis ， 2017 ， 22 ( 8 )： 1013 - 1024 .
S Y YANG , G X CHOU , Q L Li ． Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway [J]． Phytomedicine ， 2018 ， 47 ： 12 - 22 .
P NIE , F J MENG , J G ZHANG , et al . Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy in rats, partially via activating the Nrf2/HO-1 signaling pathway [J]． Oxid Med Cell Longev ， 2019 ， doi： 10.1155/2019/4625912 http://dx.doi.org/10.1155/2019/4625912 .
J WANG , D Q XIE , D Q HONG , et al . Attenuation of Myocardial ischemia reperfusion injury by Geniposide preconditioning in diabetic rats [J]． Curr Res Transl Med ， 2019 ， doi： 10.1016/j.retram.2019.03.002 http://dx.doi.org/10.1016/j.retram.2019.03.002 .
Z MENG , H Y LIANG , C Y SI , et al . Asiatic acid inhibits cardiac fibrosis through Nrf2/HO-1 and TGF- β 1 /Smads signaling pathways in spontaneous hypertension rats [J]． Int Immunopharmacol ， 2019 ， 74 ： e105712 .
史艳霞 ， 马微 ． 基于Nrf2/HO-1及NF- κ B途径探讨积雪草酸对急性心肌梗死大鼠的影响及其作用机制 [J]． 中国动脉硬化杂志 ， 2018 ， 26 ( 11 )： 1133 - 1139 .
X F ZENG , J LI , Z LI , et al . Ginsenoside Rd mitigates myocardial ischemia-reperfusion injury via Nrf2/HO-1 signaling pathway [J]． Int J Clin Exp Med ， 2015 ， 8 ( 8 )： 14497 - 14504 .
Q J QIN , N LIN , H HUANG , et al . Ginsenoside Rg1 ameliorates cardiac oxidative stress and inflammation in streptozotocin-induced diabetic rats [J]． Diabetes Metab Syndr Obes ， 2019 ， 12 ( 2 )： 1091 - 1103 .
X LI , J R DU , Y YU , et al . Tanshinone ⅡA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotidballoon-injured model through inhibition of MAPK signaling pathway [J]． J Ethnopharmacol ， 2010 ， 129 ( 2 )： 273 - 279 .
Z P LIU , J J WANG , E R HUANG , et al . Tanshinone ⅡA suppresses cholesterol accumulation in human macrophages：role of heme oxygenase-1 [J]． J Lipid Res ， 2014 ， 55 ： 203 - 213 .
雷斌 ， 唐玲 ， 张亮 ， 等 ． 虎杖苷通过激活Nrf2/HO-1信号通路减轻大鼠急性心肌梗死后心肌细胞损伤 [J]． 中国动脉硬化杂志 ， 2019 ， 27 ( 9 )： 757 - 763 .
H MAO , T TAO , X WANG , et al . Zedoarondiol attenuates endothelial cells injury induced by oxidized low-density lipoprotein via Nrf2 activation [J]． Cell Physiol Biochem ， 2018 ， 48 ： 1468 - 1479 .
Z WU , W ZAI , W CHEN , et al . Curdione ameliorated doxorubicin-induced cardiotoxicity through suppressing oxidative stress and activating Nrf2/HO-1 pathway [J]． J Cardiovasc Pharmacol ， 2019 ， dio： 10.1097/FJC.00692 http://dx.doi.org/10.1097/FJC.00692 .
J Y HAI , Y S LI , S J ZHAO , et al . Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway [J]． Cardiovasc Toxicol ， 2015 ， 16 ( 4 )： 325 - 335 .
Y ZHU , Y J ZHANG , X HUANG , et al . Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis via activating multiple NRF2 downstream genes [J]． Atherosclerosis ， 2019 ， dio： 10.1016/j.atherosclerosis.2019.02.010 http://dx.doi.org/10.1016/j.atherosclerosis.2019.02.010 .
E S CHOI , J J YOON , B H HAN , et al . Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and NO synthesis in HUVECs [J]． Phytomedicine ， 2018 ， 38 ： 12 - 23 .
王臻 ， 丁慧 ， 杨瑞 ． 黄连素激活核因子E2相关因子/血红素氧合酶-1增强内皮细胞抗过氧化氢损伤 [J]． 中国体外循环杂志 ， 2019 ， 17 ( 1 )： 41 - 47 .
张雪辰 ， 王镁 ． 中药药对治疗糖尿病肾病的药理作用及临床应用研究进展 [J]． 中国实验方剂学杂志 ， 2019 ， 25 ( 9 )： 228 - 234 .
X J ZHANG , H H HU , J X LUO , et al . A novel Danshensu-tetramethylpyrazine conjugate DT-010 provides cardioprotection through the PGC-1 α /Nrf2/HO-1 pathway [J]． Biol Pharm Bull ， 2017 ， 40 ( 9 )： 1490 - 1498 .
H LI , F SONG , L R DUAN , et al . Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: roles of Nrf2/HO-1 and PI3K/Akt pathway [J]． Sci Rep ， 2016 ， dio： 10.1038/srep23693 http://dx.doi.org/10.1038/srep23693 .
T X HU , G WEI , M M XI , et al . Synergistic cardioprotective effects of Danshensu and hydroxysafor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway [J]． Int J Mol Med ， 2016 ， 38 ( 1 )： 83 - 94 .
H J ZHANG , R C CHEN , G B SUN , tal e . Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in vivo and in vitro via regulation of Akt/Nrf2/HO-1 pathway [J]． Phytomedicine ， 2018 ， 40 ： 88 - 97 .
H YANG , S E LEE , S I JEONG , et al . Up-regulation of heme oxygenase-1 by korean red ginseng water extract as a cytoprotective effect in human endothelial cells [J]． J Ginseng Res ， 2011 ， 35 ( 1 )： 352 - 359 .
周丹丹 ． 基于Keap1-Nrf2-ARE通路探究参附芎泽方对慢性心衰大鼠氧化应激的作用机制 [D]． 西安 ： 陕西中医药大学 ， 2018 .
陈荣昌 ， 杨龙坡 ， 马晓玉 ， 等 ． 芪冬颐心口服液激活Nrf2/HO-1信号通路减轻阿霉素诱导的小鼠心肌损伤 [J]． 中国实验方剂学杂志 ， 2020 ， 26 ( 1 )： 65 - 70 .
李涵 ， 姬广辉 ， 郭立杰 ， 等 ． 玉香参附汤对心脏骤停大鼠的心肌保护作用及对Nrf2、NQO1、HO-1表达的影响 [J]． 中国中医急症 ， 2018 ， 27 ( 12 )： 2110 - 2114 .
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