Anti-oxidation and Anti-inflammatory Effect of Yixinshu Capsule in Treatment of Qi-Yin Deficiency in Viral Myocarditis

Chen WANG; Ren-dong LI; Xue-bing LIU; Pei-du JIANG; Qing-yan YANG; Xue-mei YANG

doi:10.13422/j.cnki.syfjx.20200531

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Anti-oxidation and Anti-inflammatory Effect of Yixinshu Capsule in Treatment of Qi-Yin Deficiency in Viral Myocarditis

Clinic | 更新时间：2020-09-09

- Anti-oxidation and Anti-inflammatory Effect of Yixinshu Capsule in Treatment of Qi-Yin Deficiency in Viral Myocarditis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 14, Pages: 129-134(2020)
- 作者机构：
  
  1.四川省医学科学院四川省人民医院，成都 610072
  2.成都市第五人民医院，成都 610000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20200531
  CLC： R24;R25;R242;R542.2
- Published Online：11 March 2020，
  
  Published：20 July 2020
- 稿件说明：
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王晨,李仁东,刘学兵等.益心舒胶囊治疗病毒性心肌炎气阴两虚证的抗氧化、抗炎作用观察[J].中国实验方剂学杂志,2020,26(14):129-134.

WANG Chen,LI Ren-dong,LIU Xue-bing,et al.Anti-oxidation and Anti-inflammatory Effect of Yixinshu Capsule in Treatment of Qi-Yin Deficiency in Viral Myocarditis[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(14):129-134.
王晨,李仁东,刘学兵等.益心舒胶囊治疗病毒性心肌炎气阴两虚证的抗氧化、抗炎作用观察[J].中国实验方剂学杂志,2020,26(14):129-134. DOI： 10.13422/j.cnki.syfjx.20200531.

WANG Chen,LI Ren-dong,LIU Xue-bing,et al.Anti-oxidation and Anti-inflammatory Effect of Yixinshu Capsule in Treatment of Qi-Yin Deficiency in Viral Myocarditis[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(14):129-134. DOI： 10.13422/j.cnki.syfjx.20200531.

摘要

目的

探讨益心舒胶囊治疗病毒性心肌炎（VMC）气阴两虚证的临床疗效及抗氧化、抗炎的作用。

方法

将132例亚急性期VMC患者，采用随机按数字表法分为对照组和观察组各66例。两组均注射用磷酸肌酸钠，1 g/次，1次/d，静脉滴注，连续治疗14 d；辅酶 Q10 胶囊，1粒/次，3次/d，饭后服用；盐酸曲美他嗪片，1片/次，3次/d，三餐时服用；重症患者，给予地塞米松磷酸钠注射液，10～20 mg/次，1次/d，静脉滴注，连续治疗14 d。对照组口服稳心颗粒，每次1袋，3次/d。观察组口服益心舒胶囊，3粒/次，3次/d。两组疗程均连续治疗8周。监测血清肌钙蛋白 I（cTnI）和心肌肌酸磷酸激酶（CK-MB），记录治疗后cTnI，CK-MB的复常率；进行治疗前后心电图检查，记录心电图复常率；进行治疗前后气阴两虚证评分；检测治疗前后肌酸磷酸激酶(CPK)，羟丁酸脱氢酶(HBDH)，乳酸脱氢酶(LDH)和天门冬氨酸氨基转移酶(AST)水平；进行治疗前后超声心动图检查，记录治疗前后左心室射血分数（LVEF），心脏指数(CI)和舒张早期/舒张晚期最大血流速度（E/A）；检测治疗前后超氧化物歧化酶(SOD)，丙二醛(MDA)，谷胱甘肽过氧化物酶(GSH-Px)，干扰素-

(IFN-

)，白细胞介素-10(IL-10)，IL-17和IL-35水平。

结果

采用秩和检验分析两组临床疗效，观察组优于对照组（

＝2.151，

0.05）；观察组cTnI，CK-MB和心电图复常率分别为82.26%（51/62），90.32%（56/62）和80.65%（50/62）分别高于对照组的65.00%（39/60），73.33%（44/60）和63.33%（38/60）（

0.05）；观察组患者血清cTnI，CK-MB，CPK，HBDH，LDH和AST水平均低于对照组（

0.01）；观察组患者LVEF，CI和E/A均高于对照组（

0.01）；观察组SOD和GSH-Px水平均高于对照组（

0.01），MDA水平低于对照组（

0.01）；观察组IL-10和IL-35水平均高于对照组（

0.01），IFN-

和IL-17水平均低于对照组（

0.01）。

结论

在西医常规治疗的基础上，加用益心舒胶囊治疗亚急性期VMC气阴两虚证患者，可通过抗炎和抗氧化作用而保护心肌，临床能起到降低心肌酶，促进心电图、心酶等恢复，改善心功能，提高临床治疗的效果。

Abstract

Objective

To discuss the clinical efficacy of Yixinshu capsule for viral myocarditis (VMC) with deficiency of Qi and Yin

and to investigate its antioxidant and anti-inflammatory effect.

Method

One hundred and thirty-two patients were randomly divided into control group (66 cases) and observation group (66 cases) by random number table. Patients in two group got comprehensive treatment of Western medicine

i.e. intravenous drip of creatine phosphate injection for 14 days

1 g/time

1 time/day. Coenzyme Q10 capsule

1 grain/time

3 times/day after meals. Trimetazidine dihydrochloride tablets

1 tablet/time

3 times/day during meals. And critically ill patients got intravenous drip of dexamethasone sodium phosphate injection for 14 days

10-20 mg/time

1 time/day. The control group took Wenxin granules orally

One bag at a time

3 times/day. Patients in observation group additionally got Yixinshu capsule

3 grains/time

3 times/days. The courses of treatment were 8 weeks in both groups. The serum troponin I (cTnI) and creatine phosphokinase (CK-MB) were monitored

and after treatment

the recovery rates of cTnI

CK-MB were recorded. Before and after treatment

the electrocardiogram was observed and the recovery rate after treatment was recorded. Before and after treatment

the scores of deficiency of Qi and Yin were graded

and levels of creatine phosphokinase (CPK)

hydroxybutyrate dehydrogenase (HBDH)

lactate dehydrogenase (LDH)

aspartate aminotransferase (AST)

superoxide dismutase (SOD)

malondialdehyde (MDA)

glutathione peroxidase (GSH-Px)

interferon-

(IFN-

)

interleukin-10 (IL-10)

IL-17 and IL-35 were detected. Echocardiography

left ventricular ejection fraction (LVEF)

cardiac index (CI)

and maximum velocity values between early and late diastolic (E/A) were detected.

Result

In the analysis of rank sum test

clinical efficacy in observation group was better than that in control group (

=2.151

0.05). Recovery rates of cTnI

CK-MB and electrocardiogram in observation group were 82.26% (51/62)

90.32% (56/62) and 80.65% (50/62)

higher than 65.00% (39/60)

73.33% (44/60) and 63.33% (38/60) in control group (

0.05). Levels of serum cTnI

CK-MB

CPK

HBDH

LDH

AST

MDA

IFN-

and IL-17 were lower than those in control group (

0.01)

while levels of LVEF

E/A

SOD

GSH-Px

IL-10 and IL-35 were higher than those in control group (

0.01).

Conclusion

On the basis of comprehensive anti-infection treatment

Yixinshu capsule can additional protect myocardium by anti-inflammatory and antioxidant effect

reduce myocardial enzyme

promote the recovery of ECG and cardiac enzyme

improve cardiac function and improve the effect of clinical treatment.

关键词

Keywords

references

周伟梁 , 曾凡杰 , 秦伟毅 , 等 . 心肌损伤标志物检测在诊断病毒性心肌炎中的价值 [J]. 现代预防医学 , 2015 , 42 ( 23 ): 4406 - 4408 .

中华医学会心血管病学分会精准医学学 . 成人暴发性心肌炎诊断与治疗中国专家共识 [J]. 内科急危重症杂志 , 2017 , 23 ( 6 ): 443 - 453 .

李志强 , 王学惠 , 常红娟 . 参苏饮加减治疗肺气不足型成人病毒性心肌炎的临床观察 [J]. 中国实验方剂学杂志 , 2019 , 25 ( 5 ): 73 - 78 .

金信垚 , 刘强 . 中医药治疗病毒性心肌炎的研究进展 [J]. 中国中医急症 , 2019 , 28 ( 11 ): 2050 - 2053 .

唐仕欢 , 张晶晶 , 杨洪军 . 以中医理论指导的中药大品种临床定位案例研究——以益心舒胶囊为例 [J]. 中国实验方剂学杂志 , 2019 , 25 ( 15 ): 197 - 201 .

董欢乐 , 吕玮坤 , 郑刚 . 益心舒胶囊的临床应用与实验研究进展 [J]. 黑龙江中医药 , 2016 , 45 ( 2 ): 65 - 67 .

任凤梧 , 路瑞华 , 姜小刚 , 等 . 益心舒胶囊治疗病毒性心肌炎的临床观察 [J]. 中西医结合心脑血管病杂志 , 2014 , 12 ( 2 ): 179 - 180 .

杨雪梅 . 益心舒胶囊治疗病毒性心肌炎的临床效果分析 [J]. 中国现代医生 , 2017 , 55 ( 9 ): 68 - 70 .

中华中医药学会 . 中医内科常见病诊疗指南(西医疾病部分)病毒性心肌炎 [J]. 中国中医药现代远程教育 , 2011 , 9 ( 18 ): 148 - 150 .

范帅 , 崔宏 , 胡思源 , 等 . 荣心丸治疗儿童病毒性心肌炎(气阴两虚或兼心脉瘀阻证)的多中心临床研究 [J]. 药物评价研究 , 2017 , 40 ( 1 ): 68 - 74 .

BJELAKOVIC B ， VUKOMNOVIC V ， JOVIC M ． Fulminant myocarditis in children successfully treated with high dose of methyl-prednisolone [J]. Indian J Pediatr ， 2016 ， 83 ( 3 ): 268 - 269 ．

庄振杰 , 王菁 , 何灿封 , 等 . 清热解毒法论治病毒性心肌炎 [J]. 辽宁中医药大学学报 , 2017 , 19 ( 12 ): 136 - 138 .

杨维华 , 刘祖贻 . 国医大师刘祖贻辨治小儿病毒性心肌炎 [J]. 湖南中医药大学学报 , 2017 , 37 ( 3 ): 233 - 235 .

蔡银河 , 温俊茂 , 鲁可 , 等 . 生脉注射液治疗病毒性心肌炎有效性与安全性的Meta分析 [J]. 中国循证心血管医学杂志 , 2017 , 9 ( 6 ): 644 - 649,654 .

叶宏军 , 方文华 . 黄芪注射液治疗儿童病毒性心肌炎疗效与安全性评价 [J]. 中华全科医学 , 2013 , 11 ( 1 ): 137 - 139 .

冯辉 , 陈相健 . 丹参注射液对病毒性心肌炎的疗效及其抗氧自由基的作用 [J]. 中国生化药物杂志 , 2014 , 34 ( 7 ): 81 - 83 .

梁文宝 , 陈简 . 丹参注射液辅助治疗病毒性心肌炎的抗炎及抗氧自由基的效应研究 [J]. 海南医学院学报 , 2016 , 22 ( 15 ): 1630 - 1632 .

张晶晶 , 杨瑞 , 宋魏 , 等 . 病毒性心肌炎感染患者干扰素- γ 和白细胞介素-10的表达及药物干预效果研究 [J]. 中华医院感染学杂志 , 2017 , 27 ( 7 ): 1504 - 1506 .

刘艳宾 , 贾新萍 , 秦洁洁 , 等 . 病毒性心肌炎患者治疗前后血清IL-35水平的变化及其意义 [J]. 中国现代医学杂志 , 2017 , 27 ( 6 ): 123 - 126 .

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