Effect of Erxian Shengbai Decoction Combined with Huangqi Huanagshan Soup on Leukopenia After Chemotherapy and Regulatory Effect on Immunity

YANG Shu-yan; WU Mao-lin; WU Xin

doi:10.13422/j.cnki.syfjx.20200532

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Effect of Erxian Shengbai Decoction Combined with Huangqi Huanagshan Soup on Leukopenia After Chemotherapy and Regulatory Effect on Immunity

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- Effect of Erxian Shengbai Decoction Combined with Huangqi Huanagshan Soup on Leukopenia After Chemotherapy and Regulatory Effect on Immunity
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 16, Pages: 125-130(2020)
- 作者机构：
  
  1.成都中医药大学附属医院，成都 610072
  2.四川大学华西医院，成都 610041
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20200532
  CLC： R289.5;R5;R557;R557+1
- Published Online：11 March 2020，
  
  Published：20 August 2020
- 稿件说明：
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杨淑艳,吴茂林,吴昕.二仙升白汤联合黄芪鳝鱼汤治疗化疗后白细胞减少症及对免疫功能的调节作用[J].中国实验方剂学杂志,2020,26(16):125-130.

YANG Shu-yan,WU Mao-lin,WU Xin.Effect of Erxian Shengbai Decoction Combined with Huangqi Huanagshan Soup on Leukopenia After Chemotherapy and Regulatory Effect on Immunity[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(16):125-130.
杨淑艳,吴茂林,吴昕.二仙升白汤联合黄芪鳝鱼汤治疗化疗后白细胞减少症及对免疫功能的调节作用[J].中国实验方剂学杂志,2020,26(16):125-130. DOI： 10.13422/j.cnki.syfjx.20200532.

YANG Shu-yan,WU Mao-lin,WU Xin.Effect of Erxian Shengbai Decoction Combined with Huangqi Huanagshan Soup on Leukopenia After Chemotherapy and Regulatory Effect on Immunity[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(16):125-130. DOI： 10.13422/j.cnki.syfjx.20200532.

摘要

目的

观察二仙升白汤联合黄芪鳝鱼汤治疗化疗后白细胞减少症（脾肾气虚证）的临床疗效及对免疫功能和细胞因子的调节作用。

方法

将150例患者按随机数字表法分为对照组和观察组各75例。对照组口服鲨肝醇片，60 mg/次，3次/d，连续服用6周；Ⅲ度，Ⅳ度者，加用重组人粒细胞集落刺激因子注射液（rhG-CSF），2~5 μg·kg

-1

·d

-1

，皮下注射，至中性粒细胞恢复至5.0×10

个/L(白细胞计数10.0×10

个/L)停药。对照组口服升白康颗粒，1袋/次，3次/d；观察组服用二仙升白汤和黄芪鳝鱼汤，1剂/d；连续服用6周。记录外周血白细胞（WBC）和中性粒细胞（NEUT）数量和恢复正常时间；记录感染次数和抗生素的使用时间；记录rhG-CSF使用量和时间；记录红细胞计数（RBC），血红蛋白（Hb），血小板计数(PLT)和完成化疗率；进行治疗前后中医证候评分和生活质量（KPS）评分，检测治疗前后T淋巴细胞亚群（CD3

，CD4

，CD8

，CD4

/CD8

）和自然杀伤细胞（NK）水平；检测治疗前后白细胞介素-2（IL-2），IL-6，肿瘤坏死因子-

（TNF-

）。

结果

经秩和检验分析，两组患者白细胞减少症的疗效，观察组疗效好于对照组（

＝2.057，

0.05）；观察组WBC，NEUT，RBC，Hb和PLT水平均高于对照组（

0.01）；观察组WBC和NEUT恢复正常时间均短于对照组（

0.01）；观察组感染次数少于对照组，抗生素使用时间短于对照组（

0.01），rhG-CSF使用量少于对照组和使用时间短于对照组（

0.01）；治疗后观察组WBC，NEUT复常率和完成化疗率分别为76.12%（51/67），73.13%（49/67）和92.54%（62/67），分别高于对照组的57.35%（39/68），52.94%（36/68）和79.41%（54/68）（

0.05）；观察组NK，CD3

，CD4

和CD4

/CD8

水平均高于对照组，CD8

低于对照组（

0.05）；观察组患者IL-2水平高于对照组，IL-6和TNF-

水平均低于对照组。

结论

二仙升白汤联合黄芪鳝鱼汤治疗化疗后白细胞减少症（脾肾气虚证）患者，可促进WBC，NEUT复常，还能稳定患者免疫功能，调节细胞因子，改善骨髓造血微环境，提高化疗完成率，减少感染次数和rhG-CSF用量，减轻临床症状，稳定生活质量。

Abstract

Objective

To observe the clinical efficacy of Erxian Shengbai decoction combined with Huangqi Huang soup for leucopenia (deficiency of spleen and kidney Qi) after chemotherapy

and to investigate the regulatory effect on immune function and cytokines.

Method

One hundred and fifty patients were randomly divided into control group（75 cases） and observation group （75 cases）by random number table. Patients in group got batilol tablets by oral administration for 6 weeks

60 mg/time

3 times/day. And the patients at stage Ⅲ or Ⅳ additionally received recombinant human granulocyte colony stimulating factor injection (rhG-CSF) for subcutaneous injection

2-5 μg·kg

-1

·d

-1

until the count of neutrophils recovered to 5.0×10

个/L (10.0×10

个/L for white blood cell). In the control group shengbaikang granules were taken orally

1 bag/time

3 times/day.Patients in observation group additionally received Erxian Shengbai decoction combined with Huangqi Huangshan soup for 6 weeks

1 doses/day. Number of peripheral blood leukocytes (WBC) and neutrophils (NEUT)

time to recovery

number of infections

duration of using antibiotics

dose and duration of rhG-CSF

red blood cell (RBC) count

hemoglobin (Hb)

platelets (PLT) and rate of completed chemotherapy were recorded. Scores of traditional Chinese medicine（TCM）syndrome and karnofsky performance scale (KPS) were graded before and after treatment. Levels of T lymphocyte subsets (CD3

CD4

CD8

and CD4

/CD8

)

natural killer cell (NK)

interleukin-2 (IL-2)

IL-6

and tumor necrosis factor-α (TNF-α) were all detected.

Result

In the analysis of rank sum test

to the efficacy for leucopenia in observation group was better than that in control group (Z=2.057

0.05). Levels of WBC

NEUT

RBC

Hb and PLT were higher than those in control group (P

0.01). Time to recovery

number of infections and duration of using antibiotics

dose and duration of rhG-CSF were all less than those in control group (P

0.01). After treatment

the recovery rate of WBC and NEUT as well as completed chemotherapy were 76.12% (51/67)

73.13% (49/67) and 92.54% (62/67) in observation group

higher than 57.35% (39/68)

52.94% (36/68) and 79.41% (54/68) in control group (P

0.01). Levels of NK

CD3

CD4

/CD8

and IL-2 were all higher than those in control group (P

0.01)

while levels of CD8

IL-6 and TNF-α were lower than those in control group (P

0.05).

Conclusion

Erxian Shengbai decoction combined with Huangqi Huangshan soup can promote the recovery of WBC and NEUT

stabilize the immune function

regulate cytokines

improve the microenvironment of bone marrow hematopoiesis

improve the completion rate of chemotherapy

reduce the number of infections and the amount of rhG-CSF

relieve clinical symptoms

and stabilize the quality of life in patients with leukopenia after chemotherapy (deficiency of spleen and kidney Qi).

关键词

Keywords

references

田劭丹 , 董青 , 祁烁 , 等 . 化疗后白细胞减少症中医药防治与评估专家共识 [J]. 现代中医临床 , 2018 , 25 ( 3 ): 1 - 6 .

李华 , 马箐 , 艾萍 , 等 . 中药预防肿瘤化疗后白细胞减少症随机对照试验的系统评价及Meta分析 [J]. 中国中西医结合杂志 , 2015 , 35 ( 2 ): 157 - 166 .

张喜平 , 张翔 , 杨红健 , 等 . 多种口服升白药物治疗化疗相关白细胞减少症的实验研究 [J]. 中国临床药理学与治疗学 , 2015 , 20 ( 3 ): 246 - 251 .

齐晓甜 , 张家祥 , 张晓亮 , 等 . 中药治疗化疗致白细胞减少症的研究进展 [J]. 中草药 , 2019 , 50 ( 20 ): 5088 - 5095 .

谢东杰 , 王爱迪 , 刘宝山 . 当归补血汤在血液疾病中作用机制的研究进展 [J]. 中华中医药杂志 , 2018 , 33 ( 6 ): 2488 - 2490 .

周丽 . 八珍汤合二仙汤加味治疗化疗后白细胞减少症40例 [J]. 山东中医杂志 , 2009 , 28 ( 12 ): 847 - 848 .

方玉珍，谢达莎，隋艳华，等 . 圣愈汤免疫与抗氧化作用研究 [J]. 中成药志 , 2002 , 24 ( 12 ): 950 - 952 .

杨淑艳 , 李文博 . 黄芪鳝鱼汤结合强肾灸防治小细胞肺癌化疗后白细胞减少症临床观察 [J]. 四川中医 , 2014 , 32 ( 2 ): 109 - 111 .

周剑峰 . 血液病诊疗指南 [M]. 北京 : 科学出版社 , 2013 : 74 - 81 .

范奎 , 代良敏 , 伍振峰 , 等 . 放化疗所致骨髓抑制的研究进展 [J]. 中华中医药杂志 , 2017 , 32 ( 1 ): 210 - 214 .

王均宁 . 圣愈汤及其拆方对血虚模型小鼠骨髓造血生长因子IL-6和GM-CSF的影响 [J]. 山东中药医志 , 2006 , 25 ( 7 ): 477 - 478 .

刘小菊 , 张美芝 , 陈丹 . 淫羊藿苷防治恶性肿瘤作用机制研究进展 [J]. 河北中医 , 2018 , 40 ( 11 ): 1748 - 1752 .

冯翠屏 , 陈亚娟 , 鲍渝霞 , 等 . 人参皂苷Rh 2 和辅酶Q10对骨髓抑制小鼠的保护作用 [J]. 中药药理与临床 , 2013 , 29 ( 4 ): 58 - 61 .

曲婷丽 , 王二兵 , 李震宇 , 等 . 黄芪注射液乙酸乙酯萃取物对小鼠白细胞减少症作用的代谢组学 [J]. 中成药 , 2017 , 39 ( 3 ): 455 - 461 .

唐欣 , 黄裴 . 黄芪鳝鱼汤防治气血亏虚型乳腺癌患者化疗后白细胞减少症临床观察 [J]. 亚太传统医药 , 2016 , 12 ( 7 ): 140 - 141 .

陈皎皎 , 胡陵静 , 张国铎 , 等 . 四君子汤加味对肺癌化疗骨髓抑制的作用机制 [J]. 中国实验方剂学杂志 , 2018 , 24 ( 2 ): 180 - 185 .

付方俊 , 王再红 . 升血调元颗粒在行同步放化疗白细胞减少的晚期食管癌患者中的应用价值分析 [J]. 世界华人消化杂志 , 2019 , 27 ( 6 ): 402 - 407 .

汪变红 , 张明智 , 付晓瑞 , 等 . 化放疗骨髓抑制机制及防治研究进展 [J]. 肿瘤基础与临床 , 2013 , 26 ( 2 ): 162 - 165 .

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