Effect and Mechanism of Modified Si Junzitang Combined with Heat-sensitive Moxibustion on IL-17, IL-22, IL-1<italic style="font-style: italic">α</italic> and Cys-C in Serum and Exhale Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage

Su-you ZHU; Wei-min LIAO; Zhong-bo XU; Ming-ru HUANG

doi:10.13422/j.cnki.syfjx.20200721

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Effect and Mechanism of Modified Si Junzitang Combined with Heat-sensitive Moxibustion on IL-17, IL-22, IL-1α and Cys-C in Serum and Exhale Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage

Clinic | 更新时间：2021-02-09

- Effect and Mechanism of Modified Si Junzitang Combined with Heat-sensitive Moxibustion on IL-17, IL-22, IL-1α and Cys-C in Serum and Exhale Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 10, Pages: 57-62(2020)
- 作者机构：
  
  1.江西中医药大学　附属医院，南昌　 330006
  2.江西中医药大学，南昌　 330004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20200721
  CLC： R22; R242; R2-031;R287
- Received：12 December 2019，
  
  Published Online：02 January 2020，
  
  Published：20 May 2020
- 稿件说明：
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Su-you ZHU, Wei-min LIAO, Zhong-bo XU, et al. Effect and Mechanism of Modified Si Junzitang Combined with Heat-sensitive Moxibustion on IL-17, IL-22, IL-1α and Cys-C in Serum and Exhale Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 57-62.
DOI：

Su-you ZHU, Wei-min LIAO, Zhong-bo XU, et al. Effect and Mechanism of Modified Si Junzitang Combined with Heat-sensitive Moxibustion on IL-17, IL-22, IL-1α and Cys-C in Serum and Exhale Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 57-62. DOI： 10.13422/j.cnki.syfjx.20200721.

摘要

目的：

观察四君子汤加味联合热敏灸对慢性阻塞性肺疾病(COPD)稳定期(肺脾气虚型)患者血清及呼出冷凝液(EBC)中白细胞介素-17(IL-17)，白细胞介素-22(IL-22)，白细胞介素-1

(IL-1

)，血清胱抑素-C(Cys-C)的影响。

方法：

选取2019年1月到2019年6月江西省中医院肺病科及热敏灸科符合纳入标准和排除标准的住院COPD稳定期肺脾气虚型患者共120例，采用随机分配的方法用随机数字表分为中药组、热敏灸组、对照组，3组均按照指南予以吸氧、支气管舒张剂等基本治疗，中药组予四君子汤加味治疗，热敏灸组在中药组的基础上予以热敏灸疗法，对照组予以安慰剂治疗。3组均连续治疗3个疗程，20 d/疗程。3个疗程后，比较3组患者临床疗效，第1秒用力呼气容积(FEV

)，第1秒用力呼气容积占预计值百分比(FEV

%)，用力肺活量(FVC)，血清及EBC中IL-17，IL-22，IL-1

，Cys-C的水平。

结果：

治疗前三组患者的一般临床资料，肺功能水平(FEV

，FEV

%，FVC)，血清及EBC中IL-17，IL-22，IL-1

，Cys-C的水平比较无统计学差异。经3个疗程治疗后，临床有效率中药组优于对照组(

0.05)，热敏灸组优于中药组(

0.05)，且显著优于对照组(

0.01)。与本组治疗前比较，3组患者的FEV

，FEV

%，FVC水平均明显升高(

0.05)，证候评分水平，血清及EBC中IL-17，IL-22，IL-1

，Cys-C水平均明显降低(

0.05)；其中中药组优于对照组，热敏灸组优于中药组(

0.05)，且显著优于对照组(

0.01)。

结论：

四君子汤加味联合热敏灸通过激发人体经气，提升人体免疫力，抑制炎症细胞因子，降低COPD患者血清及呼出冷凝液(EBC)中IL-17，IL-22，IL-1

，Cys-C水平，减缓炎症反应的发生，增加肺容量，改善COPD患者的通气功能，提升COPD患者的肺功能，从而有效的缓解COPD患者胸闷气喘等症状，进而提高临床疗效。

Abstract

Objective:

To observe the effect and mechanism of modified Si Junzitang combined with heat-sensitive moxibustion on interleukin-17(IL-17)

interleukin-22(IL-22)

interleukin-1

(IL-1

) and serum cystatin C(Cys-C )in serum and exhale breath condensate(EBC) of patients with chronic obstructive pulmonary disease at stable stage(COPD

Qi deficiency of lung and spleen).

Method:

Totally 120 cases of COPD(Qi deficiency of lung and spleen) treated in pulmonary department and thermal moxibustion department of Affiliated Hospital of Jiangxi University of traditional Chinese medicine from January 2019 to June 2019 were included and randomly divided into traditional Chinese medicine group

heat-sensitive moxibustion group and control group. The patients in traditional Chinese medicine group were treated with Si Junzitang

the patients in heat-sensitive Moxibustion group were treated with heat-sensitive moxibustion in addition to traditional Chinese medicine group

and the patients in control group were treated with placebo. All of the 3 groups were treated with oxygen and bronchodilator according to the guidelines. All groups received 3 consecutive courses of treatment

20 days per course. After 3 courses of treatment

the clinical efficacy of the three groups

the forced expiratory volume in one second (FEV

)

the forced expiratory volume in the estimated value in one second (FEV

the forced vital capacity (FVC)

and IL-17

IL-22

IL-1

in serum and exhale breath condensate (EBC) were measured.

Result:

There were no statistically significant difference in general clinical data

lung function levels (FEV

FEV

FVC)

serum and EBC levels of IL-17

IL-22

IL-1

and Cys-C in the first three groups. The total clinical effective rate of traditional Chinese medicine group was better than the control group (

0.05)

the heat-sensitive moxibustion group was better than the traditional Chinese medicine group (

0.05) and significantly better than the control group (

0.01). Compared with the patients before treatment

the level of lung function was improved

while IL-17

IL-22

IL-1

and Cys-C in serum and EBC were reduced(

0.05). The traditional Chinese medicine group was superior to that in the control group (

0.05)

the heat-sensitive moxibustion group was superior to that in the traditional Chinese medicine group (

0.05) and significantly superior to that in the control group (

0.01).

Conclusion:

Modified Si Junzitang combined with heat-sensitive moxibustion has an anti-inflammatory effect on COPD by stimulating bullishness of human body

improving body immunity

inhibiting inflammatory cytokines

reducing levels of inflammation cytokines IL-17

IL-22

IL-1

and chronic inflammation markers serum Cys-C and inflammatory reaction

increasing the lung capacity

improving ventilation function and pulmonary function

so as to effectively relieve chest tightness asthma and other symptoms in COPD patients

and improve the clinical efficacy.

关键词

Keywords

references

M A PONCE-GALLEGOS , A RAMIREZ-VENEGAS , R FALFAN-VALENCIA . Th17 profile in COPD exacerbations [J]. Int J Chron Obstruct Pulmon Dis ， 2017 ， 12 ( 1 )： 1857 - 1865 .

O LE ROUZIC , M PICHAVANT , E FREALLE , et al . Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations [J]. Eur Respir J ， 2017 ， 50 ( 4 )： 85 - 94 .

C M RILEY , F C SCIURBA . Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review [J]. JAMA ， 2019 ， 321 ( 8 )： 786 - 797 .

曾克武，屠鹏飞 . 中药作用靶点方法学研究进展 [J]. 中国科学：化学， 2018 ， 48 ( 11 )： 1420 - 1428 .

谢文英，包永生，王俊月，等 . 二陈汤加味对慢性阻塞性肺疾病大鼠模型肺组织PPAR γ 信号通路的影响 [J]．中国实验方剂学杂志， 2019 ， 25 ( 23 )： 26 - 33 .

纪云飞，王瑞君，李晓波 . 复方四君子汤的化学成分和药理作用研究进展 [J]. 中草药， 2016 ， 47 ( 5 )： 837 - 843 .

余智 . 温针灸对老年稳定期慢性阻塞性肺疾病患者肺功能的影响 [J]. 中医学报， 2014 ， 29 ( 4 )： 485 - 486 .

朱吉鹏 . 温针灸对老年稳定期慢性阻塞性肺疾病患者肺功能的影响 [J]. 深圳中西医结合杂志， 2017 ， 27 ( 1 )： 49 - 51 .

何琦，史华，丹阳，等 . 温针灸联合六君子汤治疗慢性阻塞性肺疾病稳定期临床研究 [J]. 时珍国医国药， 2019 ， 30 ( 1 )： 131 - 133 .

慢性阻塞性肺疾病诊治指南(2013年修订版) [J]. 中国医学前沿杂志：电子版， 2014 ， 6 ( 2 )： 67 - 80 .

申永春，文富强 . 2018年慢性阻塞性肺疾病全球创议更新解读 [J]. 中国实用内科杂志， 2018 ， 38 ( 5 )： 443 - 445 .

李建生，李素云，余学庆 . 慢性阻塞性肺疾病中医诊疗指南(2011版) [J]. 中医杂志， 2012 ， 53 ( 1 )： 80 - 84 .

中华人民共和国卫生部 . 中药新药临床研究指导原则 [M]. 北京：中国医药科技出版社， 2002 .

欧江琴，刘良丽 . 加减补肺汤治疗慢性阻塞性肺疾病稳定期肺脾气虚证 [J]. 中国实验方剂学杂志， 2013 ， 19 ( 7 )： 303 - 306 .

黄明儒，许忠波，何帆，等 . 补中益气汤加味联合缩唇呼吸疗法对慢性阻塞性肺疾病稳定期患者血清TNF-α，IL-8，IL-6，IL-1 β ，Cys-C的影响 [J]. 中国实验方剂学杂志， 2019 ， 25 ( 22 )： 60 - 65 .

王儒平，陈雪梅 . “脾为生痰之源，肺为贮痰之器”的机理 [J]. 河南中医， 2013 ， 33 ( 9 )： 1396 - 1397 .

何琦，史华，丹阳，等 . 温针灸联合六君子汤治疗慢性阻塞性肺疾病稳定期临床研究 [J]. 时珍国医国药， 2019 ， 30 ( 1 )： 131 - 133 .

熊山，丁晓晨 . 四君子汤化学成分和药理作用研究进展 [J]. 山东医学高等专科学校学报， 2017 ， 39 ( 5 )： 371 - 374 .

熊娅，方仪德，韩亚鹏，等 . 橘红素药理作用研究进展 [J]. 中成药， 2018 ， 40 ( 9 )： 2030 - 2033 .

刘巧，毕启瑞，谭宁华 . 地龙蛋白多肽类成分的研究进展 [J]. 中草药， 2019 ， 50 ( 1 )： 252 - 261 .

黄庆，李志武，马志国，等 . 地龙的研究进展 [J]. 中国实验方剂学杂志， 2018 ， 24 ( 13 )： 220 - 226 .

焦琳，迟振海，陈日新 . 浅谈热敏灸技术对针灸临床的启示——动态把握腧穴状态、按需施治是针灸临床起效的关键 [J]. 中国针灸， 2019 ， 39 ( 1 )： 54 - 58 .

伍浪明，薛丽君，伍世葵 . 热敏灸结合自制参蛤散治疗慢性阻塞性肺疾病31例临床观察 [J]. 中医药导报， 2014 ， 20 ( 11 )： 82 - 84 .

折艳涛，薛亚妮，倪晓琴 . 热敏灸对COPD稳定期患者肺功能及生活质量提升的效果分析 [J]. 实用临床医药杂志， 2017 ， 21 ( 8 )： 42 - 45 .

Z VITENBERGA , M PILMANE , A BABJONIŠEVA . The evaluation of inflammatory, anti-inflammatory and regulatory factors contributing to the pathogenesis of COPD in airways [J]. Pathol Res Pract ， 2019 ， 215 ( 1 )： 97 - 105 .

M ZHANG , Y LI , X YANG , H SHAN , et al . Serum cystatin c as an inflammatory marker in exacerbated and convalescent COPD patients [J]. Inflammation ， 2016 ， 39 ( 2 )： 625 - 631 .

O LE ROUZIC , M PICHAVANT , E FREALLE , et al . Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations [J]. Eur Respir J ， 2017 ， 50 ( 4 )： 534 - 542 .

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Effect and Mechanism of Modified Si Junzitang Combined with Heat-sensitive Moxibustion on IL-17, IL-22, IL-1α and Cys-C in Serum and Exhale Breath Condensate of Patients with Chronic Obstructive Pulmonary Disease at Stable Stage

DOI：10.13422/j.cnki.syfjx.20200721

摘要

Abstract

关键词

Keywords

references