Atomization Characteristics of Baicalin， Ursodeoxycholic Acid and Caffeic Acid in Tanreqing Inhalation Solution

Meng-jiao LIU; Chen ZANG; Shao-yong LIU; Xiao-li ZHANG; Mu-sheng ZHANG; Guo-hua WANG

doi:10.13422/j.cnki.syfjx.20200846

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Atomization Characteristics of Baicalin， Ursodeoxycholic Acid and Caffeic Acid in Tanreqing Inhalation Solution

Pharmacy Fundamentals | 更新时间：2020-08-11

- Atomization Characteristics of Baicalin， Ursodeoxycholic Acid and Caffeic Acid in Tanreqing Inhalation Solution
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 15, Pages: 137-141(2020)
- 作者机构：
  
  1.中国中医科学院中药研究所，北京 100700
  2.上海凯宝药业股份有限公司，上海 201000
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20200846
  CLC： R22;R24;R28;Q412;O657.7
- Revised：28 October 2019，
  
  Published Online：31 December 2019，
  
  Published：05 August 2020
- 稿件说明：
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刘梦娇,臧琛,刘绍勇等.痰热清吸入溶液中黄芩苷、熊去氧胆酸、咖啡酸3种代表性成分的雾化特性分析[J].中国实验方剂学杂志,2020,26(15):137-141.

LIU Meng-jiao,ZANG Chen,LIU Shao-yong,et al.Atomization Characteristics of Baicalin， Ursodeoxycholic Acid and Caffeic Acid in Tanreqing Inhalation Solution[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(15):137-141.
刘梦娇,臧琛,刘绍勇等.痰热清吸入溶液中黄芩苷、熊去氧胆酸、咖啡酸3种代表性成分的雾化特性分析[J].中国实验方剂学杂志,2020,26(15):137-141. DOI： 10.13422/j.cnki.syfjx.20200846.

LIU Meng-jiao,ZANG Chen,LIU Shao-yong,et al.Atomization Characteristics of Baicalin， Ursodeoxycholic Acid and Caffeic Acid in Tanreqing Inhalation Solution[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(15):137-141. DOI： 10.13422/j.cnki.syfjx.20200846.

摘要

目的

考察雾化器不同角度对痰热清吸入溶液递送速率及递送总量的影响，为该制剂的临床用药提供参考。

方法

选择黄芩苷、熊去氧胆酸、咖啡酸为指标成分，采用PARI Boy SX型压缩雾化吸入器（配备红芯雾化杯），配合BRS2000型呼吸模拟器，考察雾化器不同角度（上15度，下15度，上30度，下30度，偏15度，偏30度，垂直）对痰热清吸入溶液递送速率、递送总量的影响；选取成人、儿童、幼童及婴儿4种呼吸模式，测定痰热清吸入溶液中3种代表性成分的递送速率及递送总量。

结果

在相同雾化时间内，雾化器不同角度对痰热清吸入溶液中咖啡酸和熊去氧胆酸的递送速率、递送总量影响不大，而对黄芩苷影响较大，且在垂直角度下，黄芩苷的递送速率、递送总量高于其他角度。在不同呼吸模式下，药液中3种成分递送速率及递送总量有较大差异，与其他呼吸模式相比，成人呼吸模式下，黄芩苷、熊去氧胆酸、咖啡酸递送速率和递送总量均最高，递送速率分别为（555.5±16.61），（226.3±6.54），（26.1±0.32） μg·min

-1

；递送总量分别为（4 001.1±82.97），（1 754.9±63.73），（167.6±1.42） μg。

结论

雾化器的使用角度对痰热清吸入溶液的递送速率及递送总量有一定影响，建议临床使用时应尽量保持垂直角度；在4种呼吸模式下，痰热清吸入溶液递送速率及递送总量不同，提示临床应根据患者呼吸特点来调整雾化剂用量或雾化时间，以保证临床用药的安全有效。

Abstract

Objective

To investigate the effect of different angles of atomizer on the delivery rates and total delivery quantities of Tanreqing inhalation solution， so as to provide reference for the clinical use of this preparation.

Method

Taking baicalin， ursodeoxycholic acid， caffeic acid as indexes， PARI Boy SX compression atomization inhaler （equipped with red core atomizing cup） and BRS2000 respiratory simulator were used， the effects of different angles of the atomizer （upper 15 degree， lower 15 degree， upper 30 degree， lower 30 degree， partial 15 degree， partial 30 degree， vertical） on the delivery rates and total delivery quantities of Tanreqing inhalation solution were investigated. The respiratory patterns of adults， children， infants and young children were selected to determine the delivery rates and total delivery quantities of three components in Tanreqing inhalation solution.

Result

In the same atomization time， the delivery rates and the total delivery quantities of caffeic acid and ursodeoxycholic acid in Tanreqing inhalation solution were not significantly affected by the atomizer from different angles， but significantly affected baicalin. At the vertical angle， the delivery rate and total delivery quantity of baicalin were higher than the other angles. Under different respiratory modes， there were significant differences in the delivery rates and total delivery quantities of these three components in the inhalation solution. Compared with other respiratory modes， the delivery rates and total delivery quantities of baicalin， ursodeoxycholic acid and caffeic acid were the highest in the adult respiratory mode， with delivery rates of （555.5±16.61），（226.3±6.54），（26.1±0.32） μg·min

-1

and total delivery quantities of （4 001.1±82.97），（1 754.9±63.73），（167.6±1.42） μg， respectively.

Conclusion

The use angle of atomizer has a certain effect on the delivery rate and total delivery quantity of Tanreqing inhalation solution， so it is suggested that the vertical angle should be kept as far as possible in clinical use. Under the four respiratory patterns， the delivery rate and total delivery quantity of Tanreqing inhalation solution are different， suggesting that the atomization dose or atomization time should be adjusted according to the respiratory characteristics of the patients to ensure the safety and effectiveness of clinical medication.

关键词

Keywords

references

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