Chemical Constituents from Stems of <italic style="font-style: italic">Zanthoxylum bungeanum</italic>

Jing-rong LOU; Zhong-fei ZHENG; Ying LI; Chao QI; Xue CUI; Qing-qiang YAO

doi:10.13422/j.cnki.syfjx.20201111

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Chemical Constituents from Stems of Zanthoxylum bungeanum

Pharmacy Fundamentals | 更新时间：2021-02-09

- Chemical Constituents from Stems of Zanthoxylum bungeanum
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 10, Pages: 141-147(2020)
- 作者机构：
  
  1.济南大学，山东省医学科学院　医学与生命科学学院，济南　 250200
  2.山东省医学科学院　药物研究所　国家卫生部生物技术药物重点实验室　山东省罕少见病重点实验室，济南　 250062
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201111
  CLC： R284.2; R289; R22; R2-031
- Received：30 November 2019，
  
  Published Online：18 February 2020，
  
  Published：20 May 2020
- 稿件说明：
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Jing-rong LOU, Zhong-fei ZHENG, Ying LI, et al. Chemical Constituents from Stems of Zanthoxylum bungeanum[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 141-147.
DOI：

Jing-rong LOU, Zhong-fei ZHENG, Ying LI, et al. Chemical Constituents from Stems of Zanthoxylum bungeanum[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 141-147. DOI： 10.13422/j.cnki.syfjx.20201111.

摘要

目的：

对95%，75%乙醇提取花椒茎的化学成分进行分离和鉴定。

方法：

取花椒茎25 kg，经95%乙醇，75%乙醇加热回流提取3次，过滤后浓缩成浸膏。95%乙醇提取得到的浸膏，分别用石油醚、二氯甲烷、乙酸乙酯、正丁醇萃取，各萃取部分与75%乙醇提取得到的浸膏经反复硅胶柱色谱，LH-20型羟丙基葡聚糖凝胶(Sephadex LH-20)柱色谱，C

柱色谱，中压制备，重结晶等方法分离纯化，用质谱、核磁等波谱技术进行鉴定。

结果：

分离得到的16个化合物分别为白鲜碱(

)，德卡林碱(

)，花椒棚碱(

)，伪非洲防己碱(

)，茵芋碱(

)，去甲白屈菜红碱(

)，欧芹酚(

)，白蜡树素(

)，3，4，5-三甲氧基肉桂醇(

)，细辛脂素(

)，丁香树脂二甲醚(

)，丁香树脂酚(

)，刚果荜澄窃脂素(

)，邻苯二酸双(2-乙基己基)酯(

)，24-propylcholesterol(

)，蔗糖(

)。

结论：

化合物伪非洲防己碱(

)，3，4，5-三甲氧基肉桂醇(

)，24-propylcholesterol(

)为花椒属中首次分离，化合物白鲜碱(

)，欧芹酚(

)，白蜡树素(

)，细辛脂素(

)，丁香树脂二甲醚(

)，丁香树脂酚(

)，刚果荜澄窃脂素(

)，邻苯二酸双(2-乙基己基)酯(

)为花椒中首次分离。

Abstract

Objective:

To isolate and identify the chemical constituents from the 95%

75%ethanol extracts of the stems of

Zanthoxylum bungeanum

Method:

The 25 kg stems of

bungeanum

were extracted with 95%

75%ethanol for three times

and the combined filtrates were concentrated under vacuum to get the extracts. The 95%extracts were then extracted by petroleum ether

dichloromethane

ethyl acetate and

-butanol successively to obtain corresponding fractions. Such fractions and 75%extracts were isolated and purified by silicagel

Sephadex LH-20

ODS

preparation HPLC and recrystallization to obtain compounds. Their structures were identified by mass spectroscopy (MS)

and nuclear magnetic resonance (NMR).

Result:

Sixteen compounds were isolated from the stems of

bungeanum

and identified as dictamnine(

)

decarine(

)

zanthobungeanine(

)

pseudocolumbamine(

)

skimmianine(

)

norchelerythrine(

)

osthenol(

)

dimethylfraxetin(

)

5-trimethoxycinnamylalcohol(

)

asarinin(

)

yangambin(

)

syringaresinol(

)

ashantin(

)

bis

(2-ethylhexyl) benzene-1

2-dicarboxylate(

)

24-propylcholesterol(

)

and sucrose(

Conclusion:

Compounds pseudocolumbamine(

)

5-trimethoxycinnamylalcohol(

)

and 24-propylcholesterol(

)were isolated from the genus of

Zanthoxylum

for the first time and compounds dictamnine(

)

osthenol(

)

dimethylfraxetin(

)

asarinin(

)

yangambin(

)

syringaresinol(

)

ashantin(

)

and

bis

(2-ethylhexyl) benzene-1

2-dicarboxylate(

)were isolated from this plant for the first time.

关键词

Keywords

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Related Author

Jing-rong LOU

Zhong-fei ZHENG

Ying LI

Chao QI

Xue CUI

Qing-qiang YAO

CHEN Xiaoyan

ZHU Xinglong

Related Institution

Institute of Materia Medica, Shandong Academy of Medical Sciences, Key Laboratory for Biotech-Drugs Under Ministry of Health, Key Laboratory for Rare & Uncommon Diseases of Shandong Province

School of Medicine and Life Sciences, University of Ji'nan-Shandong Academy of Medical Sciences

School of Pharmacy，State Key Laboratory of Southwest Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine

China Resources Sanjiu Medical & Pharmaceutical Co. Ltd.

The Second People's Hospital of Dalian

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⁰

Chemical Constituents from Stems of Zanthoxylum bungeanum

DOI：10.13422/j.cnki.syfjx.20201111

摘要

Abstract

关键词

Keywords

references