Optimization of Processing Technology of Salt-processed Products of Plantaginis Semen Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method and Investigation of Its Diuretic Effect

Chao LI; Huan YU; Rou WEN; Li-ping YAN; Qian-feng GONG; Ling-yun ZHONG; Jin-lian ZHANG

doi:10.13422/j.cnki.syfjx.20201246

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Optimization of Processing Technology of Salt-processed Products of Plantaginis Semen Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method and Investigation of Its Diuretic Effect

Pharmacy Fundamentals | 更新时间：2020-09-16

- Optimization of Processing Technology of Salt-processed Products of Plantaginis Semen Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method and Investigation of Its Diuretic Effect
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 20, Pages: 124-131(2020)
- 作者机构：
  
  江西中医药大学药学院，南昌 330004
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201246
  CLC： R22;R28;R943.1;R965;C37
- Received：25 December 2019，
  
  Published Online：31 March 2020，
  
  Published：20 October 2020
- 稿件说明：
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李潮,于欢,温柔等.基于AHP-CRITIC混合加权法和响应面法的盐车前子炮制工艺优选及其利尿作用考察[J].中国实验方剂学杂志,2020,26(20):124-131.

LI Chao,YU Huan,WEN Rou,et al.Optimization of Processing Technology of Salt-processed Products of Plantaginis Semen Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method and Investigation of Its Diuretic Effect[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(20):124-131.
李潮,于欢,温柔等.基于AHP-CRITIC混合加权法和响应面法的盐车前子炮制工艺优选及其利尿作用考察[J].中国实验方剂学杂志,2020,26(20):124-131. DOI： 10.13422/j.cnki.syfjx.20201246.

LI Chao,YU Huan,WEN Rou,et al.Optimization of Processing Technology of Salt-processed Products of Plantaginis Semen Based on Response Surface Method and AHP-CRITIC Mixed Weighting Method and Investigation of Its Diuretic Effect[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(20):124-131. DOI： 10.13422/j.cnki.syfjx.20201246.

摘要

目的

优化盐车前子的炮制工艺，明确其工艺参数，并结合药效学研究对所得炮制工艺进行验证，为盐车前子的规范化生产和质量控制提供实验依据。

方法

以3个指标成分（京尼平苷酸、毛蕊花糖苷、异毛蕊花糖苷）质量分数、外观性状评分和干膏得率的综合评分为指标，采用层次分析法（AHP）-指标相关性的指标权重确定方法（CRITIC）混合加权法确定各评价指标的权重系数，在单因素试验基础上，利用响应面法考察炒制温度、炒制时间、加盐量和加水量对盐车前子炮制工艺的影响，并通过利尿试验对盐车前子炮制工艺进行验证，选择呋塞米片为阳性药（给药剂量0.01 g·kg

-1

）。

结果

AHP-CRITIC混合加权法确定京尼平苷酸质量分数、毛蕊花糖苷质量分数、外观性状评分、异毛蕊花糖苷质量分数、干膏得率的权重系数分别为0.319，0.193，0.207，0.273，0.008。最佳盐炙工艺参数为每100 g车前子生品于150~180 ℃文火炒制10 min，均匀喷淋盐水（食盐2 g加水20 mL使溶解）20 mL，于150~180 ℃炒制15 min，取出，放凉。与空白组比较，车前子组和盐车前子组均能增加尿量分泌量（

0.01），但盐车前子组大鼠尿液电解质Na

排泄较车前子组显著升高（

0.05）。

结论

优选的炮制工艺简单可行，可为规范盐车前子饮片的工业化生产提供参考。同时，结合盐车前子内在质量和外观性状，并利用药效学试验进行验证，所得结果更加合理可信，可用于该饮片的质量控制。

Abstract

Objective

To optimize the processing technology of salt-processed products of Plantaginis Semen with the specific process parameters

and verify the obtained processing technology by pharmacodynamic research

so as to provide experimental basis for the standardized production and quality control of this decoction pieces.

Method

Taking composite score of appearance character score

dry extract yield and contents of three components (geniposidic acid

acteoside and isoacteoside) as index

the analytic hierarchy process (AHP)-criteria importance through intercrieria correlation (CRITIC) mixed weighting method was used to determine the weight coefficient of each index. Based on single factor tests

the response surface method was used to investigate the effects of frying time

frying temperature

salt amount and water amount on the processing technology of salt-processed products of Plantaginis Semen

and the processing technology was verified by diuretic experiment with furosemide tablets as the positive drug (administration dose of 0.01 g·kg

-1

Result

The weight coefficients of geniposidic acid content

acteoside content

appearance character score

isoacteoside content and dry extract yield were 0.319

0.193

0.207

0.273 and 0.008

respectively. The optimal process parameters were as following：fried at 150-180 ℃ for 10 min (obtained from the single factor tests)

100 g of Plantaginis Semen sprayed evenly with 2 g of salt (2 g of salt dissolved in 20 mL of water)

and fried at 150-180 ℃ for 15 min. Compared with the blank group

both of the raw products group and the salt-processed products group could significantly increase the secretion of urine volume (

0.01)

but the excretion of Na

in the urine of rats in the salt-processed products group was significantly higher than that in the raw products group (

0.05).

Conclusion

The optimized processing technology is simple and feasible

which can provide reference for standardizing the industrial production of salt-processed products of Plantaginis Semen. At the same time

combined with inherent quality and appearance of the salt-processed products

and verified by pharmacodynamic test

the obtained results are reasonable and reliable

which can be used for quality control of this decoction pieces.

关键词

Keywords

references

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