Clinical Observation of Zikun Decoction in Treatment of Syndrome of Yin Deficiency and Blood Dryness in Delayed Menorrhea Cycle Due to Decreasing Ovarian Reservation

Ming-wei XIN; Ma-jian LI; Jun-qin HE; Wei YANG; Ying ZHANG; Ying WU; Xiao-dan YIN; Qian HAN

doi:10.13422/j.cnki.syfjx.20201329

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Clinical Observation of Zikun Decoction in Treatment of Syndrome of Yin Deficiency and Blood Dryness in Delayed Menorrhea Cycle Due to Decreasing Ovarian Reservation

Clinic | 更新时间：2020-08-11

- Clinical Observation of Zikun Decoction in Treatment of Syndrome of Yin Deficiency and Blood Dryness in Delayed Menorrhea Cycle Due to Decreasing Ovarian Reservation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 13, Pages: 138-143(2020)
- 作者机构：
  
  首都医科大学附属北京妇产医院，北京 100026
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201329
  CLC： R22;R242;R2-031;R287
- Published Online：20 April 2020，
  
  Published：05 July 2020
- 稿件说明：
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辛明蔚,李玛建,何军琴等.资坤汤治疗卵巢储备功能下降月经后期阴虚血燥证的临床观察[J].中国实验方剂学杂志,2020,26(13):138-143.

XIN Ming-wei,LI Ma-jian,HE Jun-qin,et al.Clinical Observation of Zikun Decoction in Treatment of Syndrome of Yin Deficiency and Blood Dryness in Delayed Menorrhea Cycle Due to Decreasing Ovarian Reservation[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(13):138-143.
辛明蔚,李玛建,何军琴等.资坤汤治疗卵巢储备功能下降月经后期阴虚血燥证的临床观察[J].中国实验方剂学杂志,2020,26(13):138-143. DOI： 10.13422/j.cnki.syfjx.20201329.

XIN Ming-wei,LI Ma-jian,HE Jun-qin,et al.Clinical Observation of Zikun Decoction in Treatment of Syndrome of Yin Deficiency and Blood Dryness in Delayed Menorrhea Cycle Due to Decreasing Ovarian Reservation[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(13):138-143. DOI： 10.13422/j.cnki.syfjx.20201329.

摘要

目的

观察资坤汤治疗卵巢储备功能下降（decreasing ovarian reservation，DOR）月经后期阴虚血燥证的临床疗效。

方法

将60例DOR月经后期阴虚血燥证患者按照随机数字表法分为对照组和观察组，各30例。对照组予雌二醇片/雌二醇地屈孕酮片治疗，观察组予资坤汤治疗。对照组从月经第1天开始服药，连服28 d，观察组从月经第5天开始服药，至下次月经来潮第1天停药。停药后随访3个月经周期。并观察两组治疗前后月经周期、中医证候积分改善情况，窦卵泡数（antral follicle count，AFC）以及血清卵泡刺激素（follicle stimulating hormone，FSH），黄体生成激素（luteinizing hormone，LH），雌二醇（estradiol，E

），抗苗勒管激素（anti-müllerian hormone，AMH），抑制素B（inhibin B，INHB）水平及FSH/LH。

结果

治疗后观察组临床有效率与对照组比较，差异无统计学意义，但观察组患者中医证候积分明显低于对照组（

0.05），观察组患者INHB明显升高（

0.05），不良反应发生率低于对照组（

0.05）。与本组治疗前比较，治疗后两组患者FSH，FSH/LH水平均明显降低（

0.05）；两组患者AMH水平均明显升高（

0.05），AFC数量明显增加（

0.05）。

结论

资坤汤治疗卵巢储备功能下降月经后期阴虚血燥证具有较好的临床疗效，可改善患者性激素水平，增加窦卵泡数，改善卵巢储备功能，促进月经来潮。

Abstract

Objective

To observe the effect of Zikun decoction (ZKD) in treatment of Yin deficiency and blood dryness in delayed menorrhea due to decreasing ovarian reservation．

Method

A total of 60 cases were randomly divided into two groups．The observation group was given ZKD orally，and the control group was treated with complex packing estradiol tablets/estradiol and dydrogestero for three months．The control group began to take medicine on the first day of menstruation for 28 days

while the observation group began to take medicine on the fifth day of menstruation

and stopped taking medicine on the first day of the next menstruation. Three menstrual cycles were followed up. The clinical syndrome scores

follicle-stimulating hormone (FSH)

luteinizing hormone (LH)

inhibin B (INHB)

FSH/LH

Estradiol (E

)

anti-müllerian hormone (AMH)

and antral follicle count (AFC) scores of the patients before and after treatment were compared.

Result

After treatment

there was no significant difference in clinical efficiency between observation group and control group

but the traditional Chinese medicine syndrome score of observation group was significantly reduced (

0.05)

observation group and control group had the same curative effect in improvement of FSH

FSH/LH

AMH and AFC (

0.05)

but ZKD was better than complex packing estradiol tablets/estradiol and dydrogestero in improvement of INHB.

Conclusion

ZKD has a good treatment effect in the treatment of DOR. It can effectively improve patients' sex hormone levels

increase antral follicle count

improve the ovarian reserve function and promote menstruation.

关键词

Keywords

references

凌琳 , 叶平 , 胡蓝雅文 . 卵巢储备功能评估指标的研究进展 [J]. 浙江医学 , 2018 , 40 ( 21 ): 2394 - 2396 .

刘传明 , 丁利军 , 李佳音 , 等 . 衰老导致卵巢功能低下研究进展 [J]. 遗传 , 2019 , 41 ( 9 ): 816 - 826 .

蒋向荣 , 郭莹 , 杨娜 , 等 . 卵巢储备功能减退病因的研究进展 [J]. 中国优生与遗传杂志 , 2017 , 25 ( 5 ): 145 - 146，117 .

陈薪 . 卵巢衰老诊疗新策略的探索性研究 [D]. 广州 : 南方医科大学 , 2016 .

杨润雨 , 张杨 , 冯晓玲 . 卵巢储备功能下降所致不孕症中西医机制及治疗进展探析 [J]. 辽宁中医药大学学报 , 2019 , 21 ( 9 ): 189 - 192 .

TACHIBANA M , KUNO T , YAEGASHI N . Mitochondrial replacement therapy and assisted reproductive technology:a paradigm shift toward treatment of genetic diseases in gametes or in early embryos [J]. Reprod Med Biol , 2018 , 17 ( 4 ): 421 - 433 .

KRISTENSEN S G , PORS S E , ANDERSEN C Y . Improving oocyte quality by transfer of autologous mitochondria from fully grown oocytes [J]. Hum Reprod , 2017 , 32 ( 4 ): 725 - 732 .

韩玉芬 , 程淑蕊 , 敬文娜，等 . 卵巢储备功能下降的预测及治疗 [J]. 中国计划生育学杂志 , 2007 , 15 ( 2 ): 117 .

孙莹璞，相文佩 . 人类卵子学 [M]. 北京 : 人民卫生出版社 , 2018 : 164 .

谢幸，苟文丽 . 妇产科学 [M]. 北京 : 人民卫生出版社 , 2013 : 360 .

中华中医药学会 . 中医妇科常见病诊疗指南 [M]. 北京 : 中国中医药出版社 , 2012 : 9 - 11 .

理习阳 . 月经后期（卵巢储备功能下降）中医临床路径的应用研究 [D]. 成都 : 成都中医药大学 , 2014 .

连方 . 中西医结合生殖医学 [M]. 北京 : 人民卫生出版社 , 2017 : 127 .

中华人民共和国卫生部 . 中药新药临床研究指导原则 [M]. 北京 : 中国医药科技出版社 , 2002 : 243 .

国家中医药管理局 . 中医病证诊断疗效标准 [M]. 中国医药科技出版社 , 1995 : 230 .

韩玉芬 , 程淑蕊 , 敬文娜 , 等 . 卵巢储备功能下降的预测及治疗 [J]. 中国计划生育学杂志 , 2007 , 15 ( 2 ): 117 .

廖旖欣 , 全松 . 卵巢储备功能的评估与控制性卵巢刺激方案的选择 [J]. 实用妇产科杂志 , 2019 , 35 ( 5 ): 324 - 326 .

李凤琼 , 冯琳 , 韩倩倩 . AMH、性激素、AFC联合年龄对不孕症患者卵巢储备功能预测的意义 [J]. 实用妇科内分泌杂志：电子版 , 2018 , 5 ( 14 ): 30 - 31 .

MARCA L A , BROEKMANS F , VOLPE A , et al . Anti-Müllerian hormone (AMH):what do we still need to know? [J]. Hum Reprod , 2009 , 24 ( 9 ): 2264 - 2275 .

MUTTUKRISHNA S , MCGARRIGLE H , WAKIM R , et al . Antral follicle count anti-mullerian hormone and inhibin B:predictors of ovarian response in assisted reproductivetechnology [J]. BJOG , 2005 , 112 ( 10 ): 1384 - 1390 .

孙爱军 , 唐旭东 , 张巧利 , 等 . 卵巢储备功能降低不孕症中西医结合治疗的理论与临床试验研究探讨 [J]. 中国实验方剂学杂志 , 2019 , 25 ( 8 ): 148 - 157 .

PERKINS M S , LOUW-DU TOIT R , AFRICANDER D . Hormone therapy and breast cancer: emerging steroid receptor mechanisms [J]. J Mol Endocrinol , 2018 , 61 ( 4 ): R133 - R160 .

王宪 , 刘金星 , 刘桂荣 . 中医周期疗法治疗不孕症的用药规律及作用机制探析 [J]. 中国实验方剂学杂志 , 2017 , 23 ( 20 ): 207 - 212 .

魏俊英 , 傅金英 . 血清抑制素B对卵巢储备功能预测的研究 [J]. 中医学报 , 2010 , 25 ( 4 ): 764 - 765 ．

HAGEN C P , AKSGLAEDE L , SORENSEN K , et al . Individual serum levels of anti-müllerian hormone in healthy girls persist through childhood and adolescence:a longitudinal cohort study [J]. Hum Reprod Oxf Engl , 2012 , 27 ( 3 ): 8616 .

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