Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis

Wen LI; Xiao-yun DAI; Xin-qiao KE

doi:10.13422/j.cnki.syfjx.20201422

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Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis

Clinic | 更新时间：2020-09-09

- Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 14, Pages: 117-122(2020)
- 作者机构：
  
  深圳市龙华区中心医院，广东深圳 518110
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201422
  CLC： R22;R242;R2-031;R287
- Published Online：06 May 2020，
  
  Published：20 July 2020
- 稿件说明：
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李雯,戴晓云,柯新桥.当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床观察[J].中国实验方剂学杂志,2020,26(14):117-122.

LI Wen,DAI Xiao-yun,KE Xin-qiao.Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(14):117-122.
李雯,戴晓云,柯新桥.当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床观察[J].中国实验方剂学杂志,2020,26(14):117-122. DOI： 10.13422/j.cnki.syfjx.20201422.

LI Wen,DAI Xiao-yun,KE Xin-qiao.Clinical Efficacy of Modified Danggui Niantongtang Combined with Xuanbitang in Treating Damp-heat Type Acute Gouty Arthritis[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(14):117-122. DOI： 10.13422/j.cnki.syfjx.20201422.

摘要

目的

探讨当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的临床疗效及对患者血清白细胞介素-1

（IL-1

），白细胞介素-6（IL-6），白细胞介素-8（IL-8），肿瘤坏死因子-

（TNF-

）的影响。

方法

将126例湿热蕴结型急性痛风性关节炎患者随机分为观察组、对照组，各63例。在非药物治疗的基础上，对照组、观察组分别使用西药常规治疗、当归拈痛汤合宣痹汤加减治疗1周，观察两组的临床疗效和治疗前后IL-1

，IL-6，IL-8，TNF-

水平。

结果

对照组临床疗效总有效率为79.37%（50/63），观察组总有效率为95.24%（60/63），观察组高于对照组（

0.05）。两组的治疗后疼痛、关节压痛、关节红肿、活动受限评分均较治疗前下降（

0.01），治疗后观察组的上述主要症状、体征评分均低于对照组（

0.05）。治疗后两组血尿酸（UA），血沉（ESR），超敏C反应蛋白（hs-CRP）水平均显著下降（

0.01），且治疗后观察组的上述指标水平均低于对照组（

0.05）。治疗后两组IL-1

，IL-6，IL-8，TNF-

水平均显著下降（

0.01），且治疗后观察组上述指标水平均低于对照组（

0.05）。

结论

与西药常规治疗比较，当归拈痛汤合宣痹汤加减治疗湿热蕴结型急性痛风性关节炎的疗效更优，并且更有效地降低IL-1

，IL-6，IL-8，TNF-

水平。

Abstract

Objective

To observe the clinical efficacy of modified Danggui Niantongtang combined with Xuanbitang in treating damp-heat type acute gouty arthritis

and investigate its effect on levels of interleukin-1

(IL-1

)

interleukin-6 (IL-6)

interleukin-8 (IL-8) and tumor necrosis factor-

(TNF-

Method

Totally 126 patients were randomly divided into control group and observation group

with 63 cases in each group. In addition to non-medication treatment

patients in control group were given conventional western medicine treatment for 1 week

while patients in observation group were given modified Danggui Niantongtang combined with Xuanbitang for 1 week. The levels of IL-1

，IL-6，IL-8，TNF-

before and after treatment were observed.

Result

The total effective rate was 79.37% in control group and 95.24% in observation group

with significant differences (

0.05). After treatment

the scores of arthralgia

tenderness

swelling

activity restriction in both groups were significantly decreased (

0.01)

and those in observation group were lower than those in control group (

0.05). The levels of uric acid (UA)

high-sensitivity C-reactive protein (hs-CRP)

erythrocyte sedimentation rate (ESR) were significantly decreased (

0.01) after treatment

and those in observation group were lower than those in the control group (

0.05). The levels of IL-1

，IL-6，IL-8，TNF-

were significantly decreased (

0.01) after treatment

and those in the observation group were lower than those in the control group (

0.05).

Conclusion

Compared with conventional western medicine treatment

modified Danggui Niantongtang combined with Xuanbitang has a better efficacy in treating damp-heat type acute gouty arthritis and reducing levels of IL-1

，IL-6，IL-8，TNF-

关键词

Keywords

references

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