Efficacy of Loulu Shengma Tang Combined with Azithromycin in Treating Children with Mycoplasma Pneumonia with Obstruction of Lung by Pathogenic Heat and Its Effect on Treg and Foxp3 mRNA

Hui-guo ZHANG; Zhi-qiao DONG; Xiao-li WANG; Tuan-ying CHEN; Xin-lei TIAN

doi:10.13422/j.cnki.syfjx.20201524

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Efficacy of Loulu Shengma Tang Combined with Azithromycin in Treating Children with Mycoplasma Pneumonia with Obstruction of Lung by Pathogenic Heat and Its Effect on Treg and Foxp3 mRNA

Clinic | 更新时间：2020-08-11

- Efficacy of Loulu Shengma Tang Combined with Azithromycin in Treating Children with Mycoplasma Pneumonia with Obstruction of Lung by Pathogenic Heat and Its Effect on Treg and Foxp3 mRNA
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 15, Pages: 90-96(2020)
- 作者机构：
  
  河南省中医院，郑州 450009
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201524
  CLC： R22;R242;R2-031;R287
- Revised：07 May 2020，
  
  Published Online：22 May 2020，
  
  Published：05 August 2020
- 稿件说明：
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张辉果,董志巧,王晓利等.漏芦升麻汤联合阿奇霉素对邪热壅肺型支原体肺炎患儿调节性T细胞及Foxp3 mRNA表达的影响[J].中国实验方剂学杂志,2020,26(15):90-96.

ZHANG Hui-guo,DONG Zhi-qiao,WANG Xiao-li,et al.Efficacy of Loulu Shengma Tang Combined with Azithromycin in Treating Children with Mycoplasma Pneumonia with Obstruction of Lung by Pathogenic Heat and Its Effect on Treg and Foxp3 mRNA[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(15):90-96.
张辉果,董志巧,王晓利等.漏芦升麻汤联合阿奇霉素对邪热壅肺型支原体肺炎患儿调节性T细胞及Foxp3 mRNA表达的影响[J].中国实验方剂学杂志,2020,26(15):90-96. DOI： 10.13422/j.cnki.syfjx.20201524.

ZHANG Hui-guo,DONG Zhi-qiao,WANG Xiao-li,et al.Efficacy of Loulu Shengma Tang Combined with Azithromycin in Treating Children with Mycoplasma Pneumonia with Obstruction of Lung by Pathogenic Heat and Its Effect on Treg and Foxp3 mRNA[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(15):90-96. DOI： 10.13422/j.cnki.syfjx.20201524.

摘要

目的

探讨漏芦升麻汤联合阿奇霉素治疗小儿邪热雍肺型小儿支原体肺炎（MPP）的临床疗效，以及对患儿调节性T细胞及核转录因子叉状头/翅膀状螺旋转录因子3（Foxp3） mRNA表达的影响。

方法

将274例MPP患儿随机分为观察组与对照组，每组各137例。观察组给予漏芦升麻汤联合阿奇霉素干混悬剂治疗，对照组单独给予阿奇霉素干混悬剂治疗。观察两组患儿治疗后体征、临床症状消失时间、中医邪热雍肺证评分、血清炎症因子白细胞介素-6（IL-6），白细胞介素-10（IL-10），肿瘤坏死因子-

（TNF-

），C反应蛋白（CRP），CD4

CD25

Treg和CD4

Foxp3

Treg及Foxp3 mRNA表达水平变化情况。比较两组患儿的临床疗效及不良反应发生率。

结果

治疗后观察组总有效率94.16%（129/137），高于观察组（77.37%，106/137）（

0.05）；观察组患儿治疗后咳嗽、肺部啰音的消失时间、退热时间及X射线检查肺部阴影消失时间均短于对照组（

0.05）；治疗后观察组中医邪热雍肺证评分的改善情况优于对照组（

0.05）；治疗后观察组血清IL-6，IL-10，TNF-

和CRP水平较对照组降低明显（

0.05，

0.01），观察组CD4

CD25

Treg，CD4

Foxp3

Treg及Foxp3 mRNA表达水平明显高于对照组（

0.05）。不良反应的发生率观察组（7/137，5.11%）低于对照组（16/137，11.68%）。

结论

漏芦升麻汤联合阿奇霉素干混悬剂治疗小儿邪热雍肺型MPP的临床疗效明显，可明显改善患儿病证，对患儿调节性T细胞及Foxp3 mRNA表达的影响优于单用阿奇霉素干混悬剂，具有效性，且不良反应的发生率较单用阿奇霉素干混悬剂低。

Abstract

Objective

To investigate the clinical efficacy of Loulu Shengma Tang combined with azithromycin in the treatment of pediatric mycoplasma pneumoniae pneumonia（MPP） with obstruction of lung by pathogenic heat， and its effect on inflammatory factors， treg and Foxp3 mRNA.

Method

Totally 274 children with MPP were divided into observation group （137 cases） and control group （137 cases）. Observation group was treated with Loulu Shengma Tang combined with azithromycin dry suspension， while control group was treated with azithromycin dry suspension alone. The changes of traditional Chinese medicine（TCM） syndrome score of pathogenic-heat obstruction in the lung， serum inflammatory cytokines ［interleukin-6 （IL-6），interleukin-10 （IL-10），tumor necrosis factor-

（TNF-

），C-reactive protein （CRP）］， CD4

CD25

Treg， CD

Foxp3

Treg and Foxp3 mRNA expressions were observed after treatment. The clinical efficacy and the incidence of adverse reactions were compared between two groups.

Result

The total effective rate of observation group was 94.16%（129/137） after treatment， which was significantly higher than 77.37% （106/137）of observation group （

0.05）. The disappearance times of cough， lung rale， fever and lung shadow in observation group were shorter than that in control group （

0.05）. After treatment， TCM syndrome score of pathogenic-heat obstruction in lung was significantly higher than those in control group （

0.05）， serum IL-6， IL-10， TNF-

and CRP levels in observation group were significantly lower than those in control group （

0.05，

0.01）， while CD4

CD25

Treg， CD

Foxp3

Treg and Foxp3 mRNA expressions were significantly higher than those in control group （

0.05）. The incidence of adverse reactions in observation group was 7/137 （5.11%）， which was significantly lower than 16/137 （11.68%） in control group.

Conclusion

The clinical efficacy of Loulu Shengma Tang combined with azithromycin dry suspension in the treatment of pediatric MPP and its effect on serum inflammatory factors （IL-6， IL-10， TNF-

， CRP）， regulatory T cells and Foxp3 mRNA expressions were better than those of azithromycin dry suspension alone. The incidence of adverse reactions of Loulu Shengma Tang was lower than that of azithromycin dry suspension alone.

关键词

Keywords

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