Effect of Juanbitang Combined with Iontophoresis and Warm Acupuncture in Treatment of Wind Cold and Blocking Collaterals Syndrome Due to External Humeral Epicondylitis

Yi ZHANG; Shan GAO; Ke CHEN; Min LI

doi:10.13422/j.cnki.syfjx.20201724

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Effect of Juanbitang Combined with Iontophoresis and Warm Acupuncture in Treatment of Wind Cold and Blocking Collaterals Syndrome Due to External Humeral Epicondylitis

Clinic | 更新时间：2020-09-09

- Effect of Juanbitang Combined with Iontophoresis and Warm Acupuncture in Treatment of Wind Cold and Blocking Collaterals Syndrome Due to External Humeral Epicondylitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 26, Issue 17, Pages: 70-76(2020)
- 作者机构：
  
  武汉市第一医院，武汉 430022
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.20201724
  CLC： R22;R242;R2-031;R287
- Published Online：06 July 2020，
  
  Published：05 September 2020
- 稿件说明：
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张艺,高珊,陈可等.蠲痹汤加减离子导入联合温针灸治疗肱骨外上髁炎风寒阻络证的临床观察[J].中国实验方剂学杂志,2020,26(17):70-76.

ZHANG Yi,GAO Shan,CHEN Ke,et al.Effect of Juanbitang Combined with Iontophoresis and Warm Acupuncture in Treatment of Wind Cold and Blocking Collaterals Syndrome Due to External Humeral Epicondylitis[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(17):70-76.
张艺,高珊,陈可等.蠲痹汤加减离子导入联合温针灸治疗肱骨外上髁炎风寒阻络证的临床观察[J].中国实验方剂学杂志,2020,26(17):70-76. DOI： 10.13422/j.cnki.syfjx.20201724.

ZHANG Yi,GAO Shan,CHEN Ke,et al.Effect of Juanbitang Combined with Iontophoresis and Warm Acupuncture in Treatment of Wind Cold and Blocking Collaterals Syndrome Due to External Humeral Epicondylitis[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(17):70-76. DOI： 10.13422/j.cnki.syfjx.20201724.

摘要

目的

观察蠲痹汤加减离子导入联合温针灸治疗肱骨外上髁炎（EH）风寒阻络证的临床疗效，及对血清氧化应激指标的影响。

方法

将2018年1月至2019年10月武汉市第一医院收治的EH风寒阻络证患者180例，随机分为温针组、中药组及联合组，每组60例；中药组给予蠲痹汤加减局部离子导入[曲池（患侧），肘髎（患侧），阿是穴（患侧）]，30 min/次/d，温针组给予温针灸治疗，1次/d，5 d/周，联合组在中药组治疗基础上给予温针灸治疗，3组患者均治疗4周。采用日本骨科协会（JOA）肘关节功能评分表、美国纽约特种外科医院（HSS）肘关节评分表、疼痛视觉模拟评分（VAS）评价各组患者治疗前后症状体征及日常生活改善情况；采用酶联免疫吸附试验（ELISA）检测各组患者治疗前后血清晚期氧化蛋白产物（AOPP），丙二醛（MDA），过氧化物歧化酶（SOD）及血红素氧化酶（HO-1）含量。比较各组患者痊愈率、总有效率及治疗结束后1，3个月复发率。

结果

与本组治疗前比较，治疗后3组患者JOA和HSS评分升高，VAS评分降低（

0.05）；联合组及中药组血清AOPP和MDA含量降低，SOD和HO-1含量升高（

0.05）。与中药组和温针组治疗后比较，联合组JOA，HSS评分及疼痛R值升高，VAS评分降低（

0.05）；与温针组治疗后比较，联合组患者血清AOPP和MDA含量降低，SOD和HO-1含量升高（

0.05）。经4周治疗后，联合组治愈率和有效率分别高于中药组（

治愈率

=4.617，

有效率

=6.471，

0.05）和温针组（

治愈率

=4.207，

有效率

=6.775，

0.05）。治疗结束1个月后，联合组治愈率和有效率高于中药组（

治愈率

=7.617，

有效率

=13.347，

0.05）和温针组（

治愈率

=4.762，

有效率

=6.277，

0.05）；联合组复发率低于中药组（

=9.32，

0.05）和温针组（

=3.899，

0.05）。治疗结束3个月后，联合组治愈率和有效率高于中药组（

治愈率

=4.789，

有效率

=9.643，

0.05）和温针组（

治愈率

=4.458，

有效率

=9.251，

0.05）；联合组复发率低于中药组（

=4.599，

0.05）和温针组（

=4.518，

0.05）。

结论

蠲痹汤加减离子导入联合温针灸治疗EH风寒阻络证具有较好的临床疗效，值得临床推广。

Abstract

Objective

To observe the clinical efficacy of Juanbitang iontophoresis combined with warm acupuncture in treatment of wind cold and blocking collaterals syndrome due to external humeral epicondylitis (EH) and the effect on serum oxidative stress index.

Method

From January 2018 to October 2019

180 patients with EH wind cold and blocking collaterals syndrome were randomly divided into the warm acupuncture group

the traditional Chinese medicine（TCM） group and the combination group

with 60 cases in each group. The TCM group was treated with modified Juanbitang combined local iontophoresis at Quchi (affected side)

Zhouliao (affected side)

Ashi (affected side)

30 min/time/day

while the warm acupuncture group was treated with warm acupuncture once a day

5 days/week. The combination group was treated with warm acupuncture in addition to the therapy of the TCM group

and the three groups were treated for 4 weeks. JOA’s elbow joint function scale

HSS’ elbow joint score scale and pain visual simulation score (VAS) were used to evaluate the symptoms and signs and the improvement of daily life before and after treatment. Enzyme linked immunosorbent assay（ELISA） method was used to detect the contents of late oxidized protein products (AOPP)

malondialdehyde (MDA)

superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) in serum of patients before and after treatment. The cure rate

the total effective rate and the recurrence rate of 1 month and 3 months after treatment were compared.

Result

Compared with before treatment

JOA and HSS scores increased

whereas VAS scores decreased (

0.05). AOPP and MDA contents decreased

while SOD and HO-1 contents increased in the combination group and the TCM group (

0.05). Compared with the TCM group and the warm acupuncture group after treatment

JOA

HSS score and pain R value increased

whereas VAS score decreased (

0.05). Compared with the warm acupuncture group after treatment

serum AOPP

MDA content decreased

while SOD

HO-1 content increased (

0.05). After 4 weeks of treatment

the cure rate and the effective rate of combination group were higher than those of the TCM group (

cure rate

=4.617

effective rate

=6.471

0.05) and the warming acupuncture group (

cure rate

=4.207

effective rate

=6.775

0.05). One month after the treatment

the cure rate and the effective rate of the combination group were higher than those of the TCM group (

cure rate

=7.617

effective rate

=13.347

0.05) and the warm acupuncture group (

cure rate

=4.762

effective rate

=6.277

0.05). The recurrence rate of the combination group was lower than that of the TCM group (

=9.32

0.05) and the warm acupuncture group (

=3.899

0.05). Three months after the treatment

the cure rate and the effective rate of the combination group were higher than those of the TCM group (

cure rate

=4.789

effective rate

=9.643

0.05) and the warm acupuncture group (

cure rate

=4.458

effective rate

=9.251

0.05). The recurrence rate of the combination group was lower than that of the TCM group (

=4.599

0.05) and the warm acupuncture group (

=4.518

0.05).

Conclusion

Modified Juanbitang and the warm acupuncture has a good clinical efficacy in the treatment of EH wind cold and blocking collaterals syndrome and is worthy of clinical promotion.

关键词

Keywords

references

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